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Biochemistry & Molecular Biology
Dayana Benchoam, Ernesto Cuevasanta, Jonathan A. Semelak, Mauricio Mastrogiovanni, Dario A. Estrin, Matias N. Moller, Beatriz Alvarez
Summary: It has been shown that proteins and peptides can release sulfur under alkaline conditions through the beta-elimination of disulfides, leading to the formation of persulfides and dehydroalanine derivatives. This study examined the formation of glutathione persulfide (GSSH/GSS-) from glutathione disulfide (GSSG) under alkaline conditions. The reaction between GSSG and HO- was found to have a second-order rate constant of approximately 10(-3) M-1 s(-1) at 25 degrees C. The formation of GSSH and the dehydroalanine derivative was confirmed using HPLC and/or mass spectrometry. However, the mixtures did not reach equilibrium within hours, and additional sulfur compounds, including thiol and diverse sulfane sulfur compounds, were also formed. These results caution against overestimating the amount of sulfane sulfur compounds in samples containing disulfides when using cold cyanolysis for quantification. Overall, this study highlights the potential source of persulfides from the beta-elimination of disulfides and emphasizes the need for caution in cold cyanolysis experiments.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Andrea Madabeni, Laura Orian
Summary: This study investigates the reductive mechanisms of dimethyl selenoxide and dimethyl sulfoxide to gain insights into the role of the chalcogen on the reaction substrate. The key role of sulfurane and selenurane intermediates is emphasized. Additionally, the ability of these systems to oxidize selenols rather than thiols and form selenyl sulfide bridges is explored computationally.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Sandro Trova, Fei Lin, Santosh Lomada, Matthew Fenton, Bhavini Chauhan, Alexandra Adams, Avani Puri, Alessandro Di Maio, Thomas Wieland, Daniel P. Sewell, Kirstin Dick, Daniel T. Wiseman, Deepti L. Wilks, Margaret M. Goodall, Mark Drayson, Farhat Khanim, Christopher Bunce
Summary: A history of infection is associated with increased risk of AML and MDS. IgM and IgG antibodies against pathogen NDPKs are found in the blood of AML patients, indicating in vivo exposure to NDPKs. Pathogen NDPKs can mimic the pro-survival activity of NM23-H1 and activate NLRP3-inflammasome in monocytes, suggesting their role in the pathogenesis of AML and MDS.
Review
Biochemistry & Molecular Biology
Moua Yang, Brian C. Smith
Summary: Thrombosis is the main cause of death in many diseases, but the mechanisms through which oxidants become prothrombotic are not clear. Protein cysteine and methionine oxidation have been found to be regulators of thrombosis. New chemical tools are needed to identify oxidized cysteine and methionine proteins in thrombosis and hemostasis, in order to understand why clots occur during oxidative stress and develop alternative therapeutic approaches for thrombotic disorders.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Chemistry, Medicinal
Yu Pang, Hao Zhang, Hui-wang Ai
Summary: Redox-active molecules play crucial roles in cell processes, and dysregulation can lead to diseases. Genetically encoded redox indicators are valuable tools for monitoring redox states.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Review
Chemistry, Medicinal
Jae-Jin Lee, Yeon Seung Park, Kong-Joo Lee
ARCHIVES OF PHARMACAL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Moon-Jung Kim, Jaeho Jeong, Jihye Jeong, Kwang Yeon Hwang, Kong-Joo Lee, Hwa-Young Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemical Research Methods
Sunghee Woo, Seong Won Cha, Stefano Bonissone, Seungjin Na, David L. Tabb, Pavel A. Pevzner, Vineet Bafna
JOURNAL OF PROTEOME RESEARCH
(2015)
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Biochemistry & Molecular Biology
Seungjin Na, Eunok Paek, Jong-Soon Choi, Duwoon Kim, Seung Jae Lee, Joseph Kwon
MOLECULAR BIOSYSTEMS
(2015)
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Biochemical Research Methods
Seungjin Na, Samuel H. Payne, Nuno Bandeira
MOLECULAR & CELLULAR PROTEOMICS
(2016)
Article
Biochemistry & Molecular Biology
Soonhwa Song, Jae-Jin Lee, Hee-Jung Kim, Jeong Yoon Lee, Jun Chang, Kong-Joo Lee
MOLECULAR AND CELLULAR BIOLOGY
(2016)
Article
Biochemical Research Methods
Seong Won Cha, Stefano Bonissone, Seungjin Na, Pavel A. Pevzner, Vineet Bafna
MOLECULAR & CELLULAR PROTEOMICS
(2017)
Review
Spectroscopy
Seungjin Na, Eunok Paek
MASS SPECTROMETRY REVIEWS
(2015)
Review
Spectroscopy
Hee-Jung Kim, Sura Ha, Hee Yoon Lee, Kong-Joo Lee
MASS SPECTROMETRY REVIEWS
(2015)
Article
Multidisciplinary Sciences
Mi-Kyung Kim, Jin-Hwan Cho, Jae-Jin Lee, Moon-Ho Son, Kong-Joo Lee
Article
Multidisciplinary Sciences
Eun Hye Lee, Kitaik Lee, Geun-Hee Kwak, Yeon Seung Park, Kong-Joo Lee, Kwang Yeon Hwang, Hwa-Young Kim
Article
Multidisciplinary Sciences
Seungjin Na, Jae-Jin Lee, Jong Wha J. Joo, Kong-Joo Lee, Eunok Paek
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Analytical
Seungjin Na, Jihyung Kim, Eunok Paek
ANALYTICAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Jihye Shin, Yumi Kwon, Seonjeong Lee, Seungjin Na, Eun Young Hong, Shinyeong Ju, Hyun-Gyo Jung, Prashant Kaushal, Sungho Shin, Ji Hyun Back, Seon Young Choi, Eun Hee Kim, Su Jin Lee, Yae Eun Park, Hee-Sung Ahn, Younghee Ahn, Mohammad Humayun Kabir, Seong-Jun Park, Won Suk Yang, Jeonghun Yeom, Oh Young Bang, Chul-Won Ha, Jin-Won Lee, Un-Beom Kang, Hye-Jung Kim, Kang-Sik Park, J. Eugene Lee, Ji Eun Lee, Jin Young Kim, Kwang Pyo Kim, Youngsoo Kim, Hisashi Hirano, Eugene C. Yi, Je-Yoel Cho, Eunok Paek, Cheolju Lee
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Biochemical Research Methods
Seunghyuk Choi, Shinyeong Ju, Jinwon Lee, Seungjin Na, Cheolju Lee, Eunok Paek
JOURNAL OF PROTEOME RESEARCH
(2020)