Review
Medicine, General & Internal
Trevor S. Barss, Behdad Parhizi, Jane Porter, Vivian K. Mushahwar
Summary: Transcutaneous spinal cord stimulation has the potential to improve sensorimotor rehabilitation by modulating spinal cord circuitry non-invasively. It can alter excitability across multiple segments of the spinal cord with single-site stimulation, and multiple sites of stimulation can converge to facilitate spinal reflex and corticospinal networks. Further mechanistic research is needed to optimize targeted rehabilitation strategies and improve clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
Giuliano Taccola, Ronaldo M. Ichiyama, V. Reggie Edgerton, Parag Gad
Summary: This review discusses the physiological states of spinal networks, highlighting the stochastic modulation by changing ensembles of proprioceptive and supraspinal input. Spinal epidural interfaces offer a platform for studying spinal network dynamics post-injury. Low-frequency epidural pulses can evoke motor responses with oscillatory patterns. The neural variability among spinal networks is seen as a fundamental mechanism of network design rather than noise interfering with movement control.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Veterinary Sciences
Kiyotaka Arai, Takamasa Itoi, Natsuki Akashi, Masahiro Miyabe, Keisuke Sugimoto, Akira Matsuda, Noritaka Maeta, Teppei Kanda, Kenji Kutara
Summary: This study performed diffusion tensor imaging (DTI) scans on adult Beagle dogs and analyzed DTI parameters in different regions. The results showed that DTI parameters significantly decreased in the caudal direction, but were not significantly correlated with vertebral levels. These findings contribute to the development of a clinical reference for evaluating spinal cord in dogs using DTI parameters.
VETERINARY SCIENCES
(2023)
Article
Neurosciences
Shuai Ren, Weihua Zhang, HongMiao Liu, Xin Wang, Xiangchen Guan, Mingzhe Zhang, Jian Zhang, Qiong Wu, Yan Xue, Dan Wang, Yong Liu, Jianyu Liu, Xiaoping Ren
Summary: The study focused on investigating the restoration of motor function following spinal cord injury through transplanting a vascularized pedicle of hemisected spinal cord to bridge the transected spinal cord. Results showed that electrical continuity was restored, leading to motor function recovery, supporting the potential effectiveness of similar operative techniques in treating SCI patients previously considered to have irreversible damage or paralysis.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Zhi-Xiao Li, Yu-Juan Li, Qian Wang, Zhi-Gang He, Mao-Hui Feng, Hong-Bing Xiang
Summary: Myocardial ischemia-reperfusion injury (MIRI) is a significant issue in clinical cardiology, with abnormal expression of long non-coding RNAs (lncRNAs) in the spinal cord potentially playing a crucial role. Using a rat MIRI model, researchers found altered expression of lncRNAs and mRNAs in the spinal cord, suggesting their potential importance in the process of MIRI.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Rehabilitation
Anthony F. DiMarco, Robert T. Geertman, Kutaiba Tabbaa, Gregory A. Nemunaitis, Krzysztof E. Kowalski
Summary: This study aimed to investigate the use of spinal cord stimulation (SCS) to improve bowel management in individuals with spinal cord injury (SCI). Results showed that SCS significantly reduced time required for bowel management, increased airway pressure generation, and improved overall quality of life. Importantly, the improvement in bowel management was associated with restoration of intra-abdominal pressure development.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Engineering, Biomedical
Zhifeng You, Xu Gao, Xinyi Kang, Wen Yang, Tiandi Xiong, Yue Li, Feng Wei, Yan Zhuang, Ting Zhang, Yifu Sun, He Shen, Jianwu Dai
Summary: Neural regeneration after spinal cord injury (SCI) is closely related to the formation of microvascular endothelial cells (MECs) mediated neurovascular unit. This study established a method for isolating primary spinal cord-derived MECs (SCMECs) with high cell yield and purity to investigate their therapeutic effects on SCI. Transcriptomics and proteomics identified differentially expressed genes and proteins in SCMECs that were involved in angiogenesis, immunity, metabolism, and cell adhesion molecular signaling. SCMECs and brain-derived MECs (BMECs) showed different levels of angiogenesis and promoted proliferation, migration, and differentiation of spinal cord or brain-derived neural stem cells (SNSC/BNSC). SCMECs in combination with the NeuroRegen scaffold showed higher effectiveness in promoting vascular reconstruction and neuronal regeneration compared to BMECs, possibly through the VEGF/AKT/eNOS-signaling pathway.
BIOACTIVE MATERIALS
(2023)
Article
Clinical Neurology
Ilknur Telkes, Amir Hadanny, Marisa DiMarzio, Girish Chitnis, Steven Paniccioli, Katherine O'Connor, Rachael Grey, Kevin McCarthy, Olga Khazen, Bryan McLaughlin, Julie G. Pilitsis
Summary: This study is the first to investigate the medio-lateral selectivity of a high-resolution spinal cord stimulation (HR-SCS) paddle in patients with chronic pain. The results suggest that HR-SCS may provide additional ipsilateral recruitment within the extremities, improving targeting of focal pain in the lower extremities. Additionally, this study supports the use of intraoperative neuromonitoring as a decision tool in thoracic SCS surgeries and provides a comprehensive methodological framework.
Article
Peripheral Vascular Disease
Asif Razee, Somanshu Banerjee, Jason Hong, Shino Magaki, Greg Fishbein, Olujimi A. Ajijola, Soban Umar
Summary: Pulmonary hypertension (PH) is associated with aberrant sympathoexcitation and neuroinflammation. Increased cardiopulmonary afferent signaling and spinal cord neuroinflammation contribute to sympathoexcitation in PH. Inhibition of spinal cord neuroinflammation improves PH and right ventricular failure (RVF).
Article
Medicine, General & Internal
Atsushi Sasaki, Roberto M. de Freitas, Dimitry G. Sayenko, Yohei Masugi, Taishin Nomura, Kimitaka Nakazawa, Matija Milosevic
Summary: This study aimed to investigate the effects of sub-motor-threshold 10-min continuous cervical tSCS on the corticospinal and spinal reflex circuit in ten able-bodied individuals. The results showed that low-intensity and short-duration continuous cervical tSCS intervention applied at rest did not significantly affect corticospinal and spinal reflex excitability. Stimulus duration and intensity, as well as parameter selection, may be critical for inducing neuromodulatory effects during cervical tSCS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Keith M. D. McNaughton, Jessica L. Witherow, Crystal B. Dupuche, Karen C. Peebles, Tom G. Elphick, Anna L. Hudson, Euan J. McCaughey, Claire L. Boswell-Ruys, Jane E. Butler
Summary: This study investigated the reflex response to brief airway occlusion in individuals with sensory incomplete cervical spinal cord injury (cSCI). The reflex was more prevalent in this group compared to those with complete cSCI and similar to able-bodied individuals. Participants without the reflex had untreated severe obstructive sleep apnea (OSA), while those with the reflex had either no, mild, or treated OSA. This study reveals novel differences in the reflex control of inspiratory muscles across the cSCI population.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Clinical Neurology
Qingyu Jiang, Gan Gao, Benzhang Tao, Haihao Gao, Hui Wang, Peixin Wang, Mengchun Sun, Aijia Shang
Summary: This study investigated the diagnosis and treatment of thoracic anterior spinal cord herniation, finding that surgical treatment effectively controlled pain symptoms, improved neurological function, and prevented recurrence of the herniation.
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
J. E. Small, V. H. Perez Perez
Summary: This study documented the prevalence and characteristics of the dominant anterior thoracic artery in human cadaveric specimens. The results showed that a dominant anterior thoracic artery is present in 94% of individuals, which has implications for ischemic events as well as surgical and endovascular procedures.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Jun Hashimoto, Shigenori Kawabata, Toru Sasaki, Yuko Hoshino, Kensuke Sekihara, Yoshiaki Adachi, Taishi Watanabe, Yuki Miyano, Yuki Mitani, Shinji Sato, Sukchan Kim, Toshitaka Yoshii, Atsushi Okawa
Summary: This study successfully achieved noninvasive and detailed visualization of electrophysiological activity in the thoracic spinal cord through magnetoneurography, using a new method of synchronized bilateral sciatic nerve stimulation, with potential significance for functional assessment of thoracic spinal cord diseases.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Jeffrey Weiler, Paul L. Gribble, J. Andrew Pruszynski
Summary: The study shows that spinal circuits can efficiently control hand movements during dynamic reaching actions, with the control depending on the hand's location relative to the target.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Ramunas Grigonis, Robertas Guzulaitis, Rokas Buisas, Aidas Alaburda
Article
Neurosciences
Robertas Guzulaitis, Jorn Hounsgaard, Aidas Alaburda
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Robertas Guzulaitis, Jorn Hounsgaard
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Robertas Guzulaitis, Jorn Hounsgaard
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Naama Rotem, Emanuel Sestieri, Jorn Hounsgaard, Yosef Yarom
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Multidisciplinary Sciences
L. Godenzini, D. Alwis, R. Guzulaitis, S. Honnuraiah, G. J. Stuart, L. M. Palmer
Summary: The study demonstrates the impact of auditory input on sensory encoding in the somatosensory cortex and its positive influence on goal-directed behavior. Auditory input enhances neuronal output and reduces response latency during goal-directed behavior in a tactile-based task.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Robertas Guzulaitis, Luca Godenzini, Lucy Maree Palmer
Summary: The anterior lateral motor cortex plays an important role in influencing behavioral performance and impulsive behavior. Planning motor actions can improve performance, but it can also lead to premature actions.
NATURE NEUROSCIENCE
(2022)
Article
Neurosciences
Urte Jasinskyte, Rokas Buisas, Inga Griskova-Bulanova, Robertas Guzulaitis
Summary: The study found that the estrus cycle can influence the generation of auditory-steady state responses (ASSRs) and that the phase of the estrus cycle should be considered when recording ASSRs in females.
Review
Neurosciences
Robertas Guzulaitis, Lucy M. Palmer
Summary: This study examines the impact of planning and anticipating motor actions on the execution of movements and the potential occurrence of impulsive behavior due to inadequate anticipation control. It reveals that, in addition to the frontal cortex and basal ganglia, the ventromedial thalamus and anterior lateral motor cortex play significant roles in mice.
TRENDS IN NEUROSCIENCES
(2023)
Article
Physiology
Jorn Hounsgaard
COMPREHENSIVE PHYSIOLOGY
(2017)