期刊
JOURNAL OF NEUROSCIENCE
卷 36, 期 21, 页码 5799-5807出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.0320-16.2016
关键词
central pattern generators; high-conductance states; irregular firing; locomotion; motoneuron
资金
- Lundbeck Foundation
- Research Council of Lithuania [MIP-048/2013]
Intense synaptic transmission during scratch network activity increases conductance and induces irregular firing in spinal motoneurons. It is not known whether this high-conductance state is a select feature for scratching or a property that goes with spinal motor network activity in general. Here we compare conductance and firing patterns in spinal motoneurons during network activity for scratching and swimming in an ex vivo carapace-spinal cord preparation from adult turtles (Trachemys scripta elegans). The pattern and relative engagement of motoneurons are distinctly different in scratching and swimming. Nevertheless, we found increased synaptic fluctuations in membrane potential, irregular firing, and increased conductance in spinal motoneurons during scratch and swim network activity. Our finding indicates that intense synaptic activation of motoneurons is a general feature of spinal motor network activity.
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