Review
Neurosciences
Riccardo Bocchi, Giacomo Masserdotti, Magdalena Goetz
Summary: A successful experiment conducted 20 years ago opened up the field of neuronal reprogramming, which has since made significant progress. These studies are not only important for clinical applications, but also provide fundamental insights into the mechanisms of cell conversion into neurons and the maintenance of neuronal identity.
Article
Cell & Tissue Engineering
Kristijan Pazur, Ioannis Giannios, Mathias Lesche, Eva Rodriguez-Aznar, Anthony Gavalas
Summary: Hoxb1 plays different roles in neuromesodermal progenitors and hindbrain neural progenitors, promoting survival and specifying neural cell differentiation through regulation of Fgf signaling and synergistic interaction with shh. This highlights the potential of Hox genes in guiding cell specification and transplantation for neurodegenerative diseases.
Article
Developmental Biology
Kayt Scott, Rebecca O'Rourke, Caitlin C. Winkler, Christina A. Kearns, Bruce Appel
Summary: Single-cell RNA sequencing of pMN cells in embryonic zebrafish trunk tissue revealed two distinct progenitor populations: one generating neurons and the other generating OPCs. A subpopulation called Pre-OPCs, marked by the expression of the homeobox transcription factor gene gsx2, was identified in the spinal cord prior to canonical OPC marker gene expression.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Michael A. Robichaux, George Chenaux, Hsin-Yi Henry Ho, Michael J. Soskis, Michael E. Greenberg, Mark Henkemeyer, Christopher W. Cowan
DEVELOPMENTAL NEUROBIOLOGY
(2016)
Article
Developmental Biology
Randall William Treffy, David Collins, Natalia Hoshino, Son Ton, Gennadiy Aleksandrovich Katsevman, Michael Oleksiak, Elizabeth Marie Runge, David Cho, Matthew Russo, Andrej Spec, Jennifer Gomulka, Mark Henkemeyer, Michael William Rochlin
DEVELOPMENTAL NEUROSCIENCE
(2016)
Article
Oncology
Aleksandra Jurek, Maria Genander, Parag Kundu, Timothy Catchpole, Xiao He, Klas Straat, Hanna Sabelstrom, Nan-Jie Xu, Sven Pettersson, Mark Henkemeyer, Jonas Frisen
EXPERIMENTAL CELL RESEARCH
(2016)
Article
Medicine, Research & Experimental
Hyeongil Kwak, Ombretta Salvucci, Roberto Weigert, Jorge L. Martinez-Torrecuadrada, Mark Henkemeyer, Michael G. Poulos, Jason M. Butler, Giovanna Tosato
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Neurosciences
Xiao-Na Zhu, Xian-Dong Liu, Hanyi Zhuang, Mark Henkemeyer, Jing-Yu Yang, Nan-Jie Xu
JOURNAL OF NEUROSCIENCE
(2016)
Letter
Multidisciplinary Sciences
Theresa Pohlkamp, Lei Xiao, Rukhsana Sultana, Asim Bepari, Hans H. Bock, Mark Henkemeyer, Joachim Herz
Article
Neurosciences
Asghar Talebian, Rachel Britton, Mark Henkemeyer
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Patrice N. Mimche, Choon M. Lee, Sylvie M. Mimche, Manoj Thapa, Arash Grakoui, Mark Henkemeyer, Tracey J. Lamb
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Xian-Dong Liu, Xiao-Na Zhu, Michael M. Halford, Tian-Le Xu, Mark Henkemeyer, Nan-Jie Xu
JOURNAL OF CELL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Xian-Dong Liu, Peng-Hui Ai, Xiao-Na Zhu, Yuan-Bo Pan, Michael M. Halford, Mark Henkemeyer, Dong-Fu Feng, Tian-Le Xu, Suya Sun, Nan-Jie Xu
Summary: The research identifies a specific PDZ scaffold protein, Lnx1, expressed in the hippocampal CA3 region that is critical for initial social behavior. Deficiency of Lnx1 leads to neuronal activity disorders and social memory impairments, along with cognitive defects, in mice. It is found that Lnx1 deletion causes NMDA receptor hypofunction, disrupting the Lnx1-NMDAR-EphB2 complex and affecting synaptic function and social memory.
MOLECULAR PSYCHIATRY
(2021)
Article
Cell Biology
Chinnaswamy Tiruppathi, Sushil C. Regmi, Dong-Mei Wang, Gary C. H. Mo, Peter T. Toth, Stephen M. Vogel, Radu V. Stan, Mark Henkemeyer, Richard D. Minshall, Jalees Rehman, Asrar B. Malik
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Multidisciplinary Sciences
Mahmoud S. Ahmed, Ping Wang, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ivan Menendez-Montes, Muhammad Ismail, Robert Bachoo, Mark Henkemeyer, Hesham A. Sadek, Enas S. Kandil
Summary: Previous studies showed that tetracycline antibiotics demeclocycline, chlortetracycline, and minocycline can inhibit EphB1 kinase activity, which was further confirmed in vivo by inhibiting phosphorylation of EphB1 in mice and effectively blocking neuropathic pain. This suggests that these drugs could be repurposed for treating neuropathic pain and potentially other conditions that benefit from inhibition of EphB1 receptor kinase activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Zhimin Huang, Simeng Liu, Anna Tang, Laith Al-Rabadi, Mark Henkemeyer, Patrice N. Mimche, Yufeng Huang
Summary: The study reveals that EphB2 receptor tyrosine kinase plays a key role in renal fibrosis, with its expression and activation being closely associated with fibrotic development following kidney injury.
Article
Biology
Asghar Talebian, Mark Henkemeyer
COMMUNICATIONS BIOLOGY
(2019)
Article
Developmental Biology
Asghar Talebian, Rachel Britton, Simon Ammanuel, Asim Bepari, Francis Sprouse, Shari G. Birnbaum, Gabor Szabo, Nobuaki Tamamaki, Jay Gibson, Mark Henkemeyer
DEVELOPMENTAL BIOLOGY
(2017)