Article
Neurosciences
Rebecca W. Pak, Jeeun Kang, Emad Boctor, Jin U. Kang
Summary: In this study, a series of optimal tissue concentrations of VSD were established, maximizing the detection of membrane potential responses to external stimuli by varying the concentration of IR-780 perchlorate VSD in the brain.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Kamil Pradel, Gniewosz Drwiega, Tomasz Blasiak
Summary: Dopaminergic neurons in the midbrain are controlled by various brain structures, with the superior colliculus providing sensory input to the contralateral rostromedial tegmental nucleus (RMTg), an inhibitory input to dopaminergic neurons. Activation of the contralateral superior colliculus excites RMTg neurons, while stimulation of the ipsilateral side leads to both excitatory and inhibitory responses, suggesting a role of this pathway in orienting and motivation-driven locomotion of animals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Qingpeng Yu, Hang Fu, Gang Wang, Jiayi Zhang, Biao Yan
Summary: The study found that visual experience can potentiate spontaneous activity in mouse superior colliculus neurons, with feature selectivity for direction and orientation. By stimulating retinal ganglion cells or optogenetically activating parvalbumin neurons, this potentiation can be attenuated or blocked.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Clara Bourrelly, Corentin Massot, Neeraj J. Gandhi
Summary: Sensorimotor transformation is the process of sensing and responding to stimuli, and this study investigates the neural activity in the superior colliculus during visually guided eye movements. The study compares spike bursts and local field potential (LFP) modulations along the dorsoventral axis of the superior colliculus and finds a transition from sensory to motor response in both signals, with the LFP transition occurring deeper than the spike burst transition. The results suggest a fast and efficient transformation between LFP modulation and spike burst during sensation, but not during action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Tian Tian, Yifang Yuan, Srinjoy Mitra, Istvan Gyongy, Matthew F. Nolan
Summary: Establishing the biological basis of cognition and its disorders requires high precision measurement of neural activity. This study reports the application of single photon avalanche diode (SPAD) sensors for high-speed imaging of neural activity, allowing for resolution of subthreshold and spiking activity and revealing millisecond scale synchronization.
Article
Chemistry, Multidisciplinary
Matthias Filez, Martin Vesely, Ivan Garcia-Torregrosa, Marianna Gambino, Oezguen Attila, Florian Meirer, Eugene A. Katrukha, Maarten B. J. Roeffaers, Jan Garrevoet, Lukas C. Kapitein, Bert M. Weckhuysen
Summary: The study revealed the dynamic process of hierarchical porosity formation within a zeolite ZSM-5 crystal, showing that pores initiate at the crystal surface and propagate to the crystal core with decreasing rate. Additionally, hierarchical porosity only establishes in specific subunits which constitute ZSM-5, indicating that the spacedependent meso- and macroporosity within a zeolite crystal may lead to local discrepancies in diffusion, performance, and deactivation behaviors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Neurosciences
Matthew W. McDonald, Matthew S. Jeffers, Melissa Filadelfi, Andrea Vicencio, Gavin Heidenreich, Junzheng Wu, Gergely Silasi
Summary: Brain microinfarcts are prevalent in humans, and in mice, a novel and semi-automated workflow has been developed to accurately determine the anatomic location of microspheres within the brain using histologic processing and atlas registration. The distribution of microspheres was found to be brain-wide, with the highest density in the thalamus.
Review
Chemistry, Analytical
Nikolay Aseyev, Violetta Ivanova, Pavel Balaban, Evgeny Nikitin
Summary: The optical imaging of neuronal activity with potentiometric probes has been widely used in neuroscience research to study the dynamics of neural activity. Although voltage imaging has its technical difficulties and limitations, it provides unique information that cannot be obtained via other methods. Different types of optical voltage indicators have their advantages and limitations, and their contribution to neuroscience research is evaluated in this article.
Review
Neurosciences
Lu Bai, Zhenkun Zhang, Lichen Ye, Lin Cong, Yuchen Zhao, Tianlei Zhang, Ziqi Shi, Kai Wang
Summary: Recording diverse and dynamic activities in large populations of neurons in behaving animals is vital for understanding the brain. Optical imaging techniques have high throughput but limited readout speed. Light field microscopy, with its parallelized 3D fluorescence imaging scheme, offers a faster strategy for functional imaging of neural activity.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Alison S. Walker, Benjamin K. Raliski, Dat Vinh Nguyen, Patrick Zhang, Kate Sanders, Kaveh Karbasi, Evan W. Miller
Summary: The combination of voltage imaging and patterned microisland hippocampal culture allows for imaging and reconstruction of complete neuronal ensembles, revealing preferential connectivity patterns between different cell types in the network. This method has the potential to explore neuronal function in healthy and disease states by sampling the entire neuronal network simultaneously and revealing all functional connections.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rafael Pedrosa, Chenchen Song, Thomas Knopfel, Francesco Battaglia
Summary: A new generation of optogenetic tools has contributed to understanding classical open questions in neuroscience. Voltage imaging technologies using genetically encoded voltage indicators have been increasingly used to observe the dynamics of brain circuits. This article describes a method that combines voltage imaging with electrophysiology to study hippocampal-neocortical interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Mathematical & Computational Biology
Tyler R. Peel, Suryadeep Dash, Stephen G. Lomber, Brian D. Corneil
Summary: Our study explores the impact of large yet reversible inactivation of the frontal eye fields (FEF) on the activity of the intermediate layers of the superior colliculus (iSC). The results demonstrate that during FEF inactivation, the iSC emits fewer spikes for metrically-matched saccades, with a greater decrease in spike count observed for more cognitively-demanding tasks.
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Joscelin E. G. Smith, Jesse L. Ashton, Liam P. Argent, Juliette E. Cheyne, Johanna M. Montgomery
Summary: The intrinsic cardiac nervous system (ICNS) consists of interconnected clusters of neurons known as ganglionated plexi (GP) which play a crucial role in controlling heart rate and rhythm. Plasticity in GP neural networks is believed to be responsible for cardiac arrhythmias such as atrial fibrillation (AF). In this study, a calcium imaging method was developed to visualize plasticity in neuronal activity in intact atrial GP networks in rats with chronic hypertension, and the results showed significant differences in calcium responses between hypertensive rats and normal controls, suggesting a potential link between arrhythmia and plasticity in calcium dynamics in GP neurons.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Areg Barsegyan, James L. McGaugh, Benno Roozendaal
Summary: Previous findings suggest that glucocorticoid hormones can impair working memory by increasing cAMP-dependent protein kinase (PKA) activity within the prefrontal cortex (PFC) through the interaction with the 8-adrenoceptor-cAMP signaling cascade. This study investigated the role of L-type voltage-gated Ca2+ channels (LTCCs) in mediating the effects of glucocorticoid and PKA on spatial working memory. The results show that inhibition of LTCCs can block the impairment of working memory induced by either glucocorticoid receptor agonist or PKA activator, while activation of LTCCs alone is sufficient to impair working memory.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Akio Tamura, Eisuke Mukaida, Yoshitaka Ota, Masayoshi Kamata, Shun Abe, Kunihiro Yoshioka
Summary: The study found that the image quality of DLR was superior to MBIR and FBP on low-dose abdominal CT. DLR was the only method for which image noise was not higher for obese patients than for those with a normal BMI. This study provides previously unavailable information on the properties of DLR systems and their clinical utility.
BRITISH JOURNAL OF RADIOLOGY
(2021)
Article
Engineering, Biomedical
Guojun Chen, Liwei Wang, Travis Cordie, Corinne Vokoun, Kevin W. Eliceiri, Shaoqin Gong
Article
Engineering, Biomedical
Cole R. Drifka, Agnes G. Loeffler, Corinne R. Esquibel, Sharon M. Weber, Kevin W. Eliceiri, W. John Kao
BIOMEDICAL MICRODEVICES
(2016)
Article
Surgery
Jenny Tzujane Chen, Brian Eisinger, Corinne Esquibel, Samuel O. Poore, Kevin Eliceiri, John W. Siebert
PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Multidisciplinary Sciences
Corinne R. Vokoun, Meyer B. Jackson, Michele A. Basso
BASIC AND CLINICAL OCULAR MOTOR AND VESTIBULAR RESEARCH
(2011)
Article
Engineering, Biomedical
Amelia A. Schendel, Michael W. Nonte, Corinne Vokoun, Thomas J. Richner, Sarah K. Brodnick, Farid Atry, Seth Frye, Paige Bostrom, Ramin Pashaie, Sanitta Thongpang, Kevin W. Eliceiri, Justin C. Williams
JOURNAL OF NEURAL ENGINEERING
(2014)
Article
Neurosciences
Corinne R. Vokoun, Xin Huang, Meyer B. Jackson, Michele A. Basso
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Nima Ghitani, Peter O. Bayguinov, Corinne R. Vokoun, Shane McMahon, Meyer B. Jackson, Michele A. Basso
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin
MOLECULAR NEURODEGENERATION
(2019)
Article
Neurosciences
Corinne R. Esquibel, Kristy D. Wendt, Heui C. Lee, Janak Gaire, Andrew Shoffstall, Morgan E. Urdaneta, Jenu Chacko, Sarah K. Brodnick, Kevin J. Otto, Jeffrey R. Capadona, Justin C. Williams, K. W. Eliceiri
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Surgery
Jacqueline S. Israel, Corinne R. Esquibel, Aaron M. Dingle, Yuming Liu, Adib Keikhosravi, Jane A. Pisaniello, Madison A. Hesse, Sarah K. Brodnick, Joseph Novello, Lisa Krugner-Higby, Justin C. Williams, Kevin W. Eliceiri, Samuel O. Poore
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2017)
Article
Chemistry, Multidisciplinary
Guojun Chen, Renata Jaskula-Sztul, Corinne R. Esquibel, Irene Lou, Qifeng Zheng, Ajitha Dammalapati, April Harrison, Kevin W. Eliceiri, Weiping Tang, Herbert Chen, Shaoqin Gong
ADVANCED FUNCTIONAL MATERIALS
(2017)