Article
Biology
Ya-tang Li, Markus Meister
Summary: The superior colliculus in the brain is a crucial visual processing station that receives input from various types of retinal ganglion cells. Through recording mouse superficial SC neurons, we identified 24 functional types using an unsupervised clustering algorithm. These types can be grouped into two categories: one that responds similarly to retinal ganglion cells and another with more diverse and specialized stimulus selectivity. Cells of the same functional type tend to cluster together in anatomical space, and the visual representation in the SC has lower dimensionality compared to the retina, suggesting a sifting process along the visual pathway.
Article
Biochemistry & Molecular Biology
Anna M. Lavezzi, Riffat Mehboob, Francesco Piscioli, Teresa Pusiol
Summary: The aim of this study was to investigate the involvement of the mesencephalic superior colliculus (SC) in the pathogenetic mechanism of SIDS. In-depth neuropathological investigations showed alterations in the laminar arrangement of the SC deep layers in 69% of SIDS cases, but never in the controls. These SC anomalies represent a new step in understanding the pathogenetic process of SIDS.
Article
Biology
Sebastian H. Zahler, David E. Taylor, Joey Y. Wong, Julia M. Adams, Evan H. Feinberg
Summary: The study shows that mice can make sensory-guided gaze shifts involving both eye movements and attempted head movements. The flexibility of mouse gaze shifts is revealed under head-fixed conditions, offering insights into the characteristics of mouse gaze shifts and laying the foundation for studying the coupling between head and eye movements.
Review
Neurosciences
Xue Liu, Hongren Huang, Terrance P. Snutch, Peng Cao, Liping Wang, Feng Wang
Summary: This review provides insight into the phenotypic diversity of SC neurons, their intrinsic circuits, and long-projection targets. It contributes to the understanding of SC functioning and the pathology associated with SC dysfunction.
NEUROSCIENCE BULLETIN
(2022)
Article
Behavioral Sciences
James M. Shine
Summary: The thalamus and superior colliculus play crucial roles in higher-order functions of the brain, such as working memory and attention. The connections between them and their location within the brain circuitry shape complex dynamics and conscious awareness. This perspective leads to testable predictions about the interactions between different regions within the thalamus.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Letter
Clinical Neurology
Thomas Nyffeler, Brigitte C. Kaufmann, Dario Cazzoli
Summary: This case report details a young, healthy woman with a small abscess in the right superior colliculus.
Article
Biochemistry & Molecular Biology
Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Monika Bubka, Kamil Pradel, Aleksandra Klekocinska, Jasmin Daniela Klich, Amalia Ridla Rahim, Jihwan Myung, Mariusz Kepczynski, Marian Henryk Lewandowski
Summary: The study reveals a coordination between the orexin system and the rodent superior colliculus across the day-night cycle, with orexin input predominantly occurring nocturnally and the SC neurons responding to orexin A and exhibiting circadian expression of clock genes.
Article
Biology
Carlos Andres Mendez, Alessia Celeghin, Matteo Diano, Davide Orsenigo, Brian Ocak, Marco Tamietto
Summary: The superior colliculus (SC) is capable of recognizing and categorizing emotional features from retinal information, independently of additional processing in the visual cortex or limbic areas. The SC model exhibits similar error patterns to humans and shows preference for specific visual features and processing pathways.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Tatiana Malevich, Tong Zhang, Matthias P. Baumann, Amarender R. Bogadhi, Ziad M. Hafed
Summary: Visual processing is divided into ON and OFF channels from the retina to the primary visual cortex. This study investigated the timing of neural processing for dark and bright stimuli in the superior colliculus of monkeys. The results showed that, regardless of individual neural sensitivity, dark stimuli elicited faster neural responses compared to bright stimuli. These findings suggest the existence of a visual neural pathway that contributes to behavioral differences between the processing of darks and brights, emphasizing the importance of temporal aspects in visual neural coding.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Christopher Conroy, Rakesh Nanjappa, Robert M. Mcpeek
Summary: In this study, the researchers investigated the representation of inhibitory tagging in the superior colliculus (SC) during visual search. They found that SC neurons showed greater activity when their response field stimulus was a target compared to a distractor, and the activity was reduced when the stimulus had been previously fixated. Moreover, the reduction of activity was larger for targets than for distractors and decreased with increasing time since fixation. These results suggest that inhibitory tagging plays an important role in visual search and is represented in SC neurons as part of a priority map used for saccade target selection.
JOURNAL OF NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Hui Chen, Elise L. Savier, Victor J. DePiero, Jianhua Cang
Summary: Through studying the mouse superior colliculus, it was found that direction-selective neurons are not organized into stereotypical columns, but rather exist in clusters. This phenomenon is not affected by factors such as animal state, SC depth, research technique, and stimulus type, challenging recent reports on region-specific organizations in the mouse SC.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Kamil Pradel, Gniewosz Drwiega, Tomasz Blasiak
Summary: Dopaminergic neurons in the midbrain are controlled by various brain structures, with the superior colliculus providing sensory input to the contralateral rostromedial tegmental nucleus (RMTg), an inhibitory input to dopaminergic neurons. Activation of the contralateral superior colliculus excites RMTg neurons, while stimulation of the ipsilateral side leads to both excitatory and inhibitory responses, suggesting a role of this pathway in orienting and motivation-driven locomotion of animals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Clara Bourrelly, Corentin Massot, Neeraj J. Gandhi
Summary: Sensorimotor transformation is the process of sensing and responding to stimuli, and this study investigates the neural activity in the superior colliculus during visually guided eye movements. The study compares spike bursts and local field potential (LFP) modulations along the dorsoventral axis of the superior colliculus and finds a transition from sensory to motor response in both signals, with the LFP transition occurring deeper than the spike burst transition. The results suggest a fast and efficient transformation between LFP modulation and spike burst during sensation, but not during action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Qingpeng Yu, Hang Fu, Gang Wang, Jiayi Zhang, Biao Yan
Summary: The study found that visual experience can potentiate spontaneous activity in mouse superior colliculus neurons, with feature selectivity for direction and orientation. By stimulating retinal ganglion cells or optogenetically activating parvalbumin neurons, this potentiation can be attenuated or blocked.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Sanjay N. Awathale, Akash M. Waghade, Harish M. Kawade, Gouri Jadhav, Amit G. Choudhary, Sneha Sagarkar, Amul J. Sakharkar, Nishikant K. Subhedar, Dadasaheb M. Kokare
Summary: The experiment in rats showed that training with light cues can enhance learning and memory formation, possibly related to increased neuronal activity and BDNF expression. Additionally, glutamatergic signaling and dopamine secretion may play a role in memory formation and behavioral changes.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Surgery
Jenny Tzujane Chen, Brian Eisinger, Corinne Esquibel, Samuel O. Poore, Kevin Eliceiri, John W. Siebert
PLASTIC AND RECONSTRUCTIVE SURGERY
(2018)
Article
Cell & Tissue Engineering
Ashlee M. Strubberg, Daniel A. Veronese Paniagua, Tingting Zhao, Leeran Dublin, Thomas Pritchard, Peter O. Bayguinov, James A. J. Fitzpatrick, Blair B. Madison
Review
Neurosciences
Shane M. McMahon, Meyer B. Jackson
TRENDS IN NEUROSCIENCES
(2018)
Meeting Abstract
Biophysics
Shane M. McMahon, Meyer B. Jackson
BIOPHYSICAL JOURNAL
(2019)
Article
Biophysics
Young Guang, Tom M. McGrath, Natalie R. Klug, Robert J. Nims, Chien-Cheng Shih, Peter O. Bayguinov, Farshid Guilak, Christine T. N. Pham, James A. J. Fitzpatrick, Lori A. Setton
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Neurosciences
Sonia George, Nolwen L. Rey, Trevor Tyson, Corinne Esquibel, Lindsay Meyerdirk, Emily Schulz, Steven Pierce, Amanda R. Burmeister, Zachary Madaj, Jennifer A. Steiner, Martha L. Escobar Galvis, Lena Brundin, Patrik Brundin
MOLECULAR NEURODEGENERATION
(2019)
Article
Biology
Slavica Pavlovic Djuranovic, Jessey Erath, Ryan J. Andrews, Peter O. Bayguinov, Joyce J. Chung, Douglas L. Chalker, James A. J. Fitzpatrick, Walter N. Moss, Pawel Szczesny, Sergej Djuranovic
Article
Neurosciences
Corinne R. Esquibel, Kristy D. Wendt, Heui C. Lee, Janak Gaire, Andrew Shoffstall, Morgan E. Urdaneta, Jenu Chacko, Sarah K. Brodnick, Kevin J. Otto, Jeffrey R. Capadona, Justin C. Williams, K. W. Eliceiri
FRONTIERS IN NEUROSCIENCE
(2020)
Review
Biochemistry & Molecular Biology
Peter O. Bayguinov, Max R. Fisher, James A. J. Fitzpatrick
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Editorial Material
Gastroenterology & Hepatology
Ramon U. Jin, Jeffrey W. Brown, Qing Kay Li, Peter O. Bayguinov, Jean S. Wang, Jason C. Mills
Article
Gastroenterology & Hepatology
Elizabeth P. Newberry, Zoe Hall, Yan Xie, Elizabeth A. Molitor, Peter O. Bayguinov, Gregory W. Strout, James A. J. Fitzpatrick, Elizabeth M. Brunt, Julian L. Griffin, Nicholas O. Davidson
Summary: The study demonstrates that liver-specific Tm6SF2 deletion impairs VLDL secretion, leading to hepatic steatosis, fibrosis, and accelerated development of HCC. This impact can be mitigated with AAV8-mediated rescue, showing promise for potential therapeutic interventions.
Article
Neurosciences
Yihe Ma, Peter O. Bayguinov, Shane M. McMahon, Helen E. Scharfman, Meyer B. Jackson
Summary: The dentate gyrus relies on excitatory neurons called mossy cells to gate and process information entering the hippocampus. These mossy cells form synaptic connections with each other and with inhibitory neurons and granule cells, playing a crucial role in transmitting and redistributing signals within the dentate gyrus network. Excitation from mossy cells can shape and modulate the electrical activity underlying hippocampal functions, such as navigation and memory, influencing seizures as well.
Article
Cardiac & Cardiovascular Systems
Benjamin J. Kopecky, Hao Dun, Junedh M. Amrute, Chieh-Yu Lin, Andrea L. Bredemeyer, Yuriko Terada, Peter O. Bayguinov, Andrew L. Koenig, Christian C. Frye, James A. J. Fitzpatrick, Daniel Kreisel, Kory J. Lavine
Summary: This study investigates the role of donor immune cells in heart transplantation and identifies donor CCR2(+) macrophages as key mediators of allograft rejection. Deletion of MYD88 signaling in donor macrophages suppresses rejection and extends allograft survival. These findings highlight the potential for interventions targeting donor immune cells in heart transplantation.
Article
Engineering, Biomedical
Yihe Ma, Peter O. Bayguinov, Meyer B. Jackson
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2019)
Article
Surgery
Jacqueline S. Israel, Corinne R. Esquibel, Aaron M. Dingle, Yuming Liu, Adib Keikhosravi, Jane A. Pisaniello, Madison A. Hesse, Sarah K. Brodnick, Joseph Novello, Lisa Krugner-Higby, Justin C. Williams, Kevin W. Eliceiri, Samuel O. Poore
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2017)