Article
Multidisciplinary Sciences
Andrea Roeser, Vikram Gadagkar, Anindita Das, Pavel A. Puzerey, Brian Kardon, Jesse H. Goldberg
Summary: This study investigates how dopamine signals change in response to different priorities and opportunities in the environment. The findings suggest that the dopamine system can dynamically adjust its signals to accommodate different reward settings based on the current priority. This flexibility allows the brain to prioritize and adapt to varying needs and motivations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chang Liu, Yu Shi, Gongyu Lan, Youli Xu, Fei Yang
Summary: This study evaluated pancreatic stiffness, size, and fibrosis levels using magnetic resonance imaging techniques, and the results showed that a combination of MRE and T1 mapping can better diagnose pancreatic fibrosis, especially at an early stage.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Neurosciences
Adam Gordon-Fennell, Garret D. Stuber
Summary: Studies have revealed generalizable findings across molecularly defined cell types in areas of the basal forebrain and anterior hypothalamus. Optogenetic stimulation of GABAergic neurons in these brain regions drives reward, while optogenetic stimulation of glutamatergic neurons in these regions drives aversion.
Article
Geriatrics & Gerontology
Clara Rodriguez-Sabate, Ingrid Morales, Manuel Rodriguez
Summary: This study investigates the impact of aging on the functional connectivity of the basal ganglia motor circuit. The results show significant changes in connectivity induced by aging, which may contribute to motor handicaps in older individuals during motor task execution and at rest.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neuroimaging
Samantha Tan, Septian Hartono, Thomas Welton, Chu Ning Ann, Soo Lee Lim, Tong San Koh, Huihua Li, Fiona Setiawan, Samuel Ng, Nicole Chia, Saifeng Liu, E. Mark Haacke, Eng King Tan, Louis Chew Seng Tan, Ling Ling Chan
Summary: QSM and DKI are complementary tools that provide valuable insights into the complex pathological changes in early Parkinson's disease, particularly in relation to iron deposition and microstructural alterations. These technologies have the potential to be clinically useful for early diagnosis and assessment of PD.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Kenneth A. Amaya, Kyle S. Smith
Summary: The findings suggest that ChIs in the DLS play a crucial role in behavioral flexibility and exploration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biology
Allison E. Hamilos, Giulia Spedicato, Ye Hong, Fangmiao Sun, Yulong Li, John A. Assad
Summary: The study revealed that dopamine signals play a crucial role in the timing of reward-related movements in animals, with the signals gradually increasing over time to predict movement/reward timing. The dynamics of dopamine signals can modulate the probability of movement initiation, providing important insights into the decision of when to move.
Article
Neurosciences
Estelle Raffin, Adrien Witon, Roberto F. Salamanca-Giron, Krystel R. Huxlin, Friedhelm C. Hummel
Summary: Discrimination and integration of motion direction involve the interplay of multiple brain areas. The impact of task demand and perceptual decision-making on brain activity occurs at different levels of the visual hierarchy. Lower levels of the visual network support early, feature-based selection, while higher levels integrate sensory information with the subject's internal state, which is predictive of performance.
Article
Multidisciplinary Sciences
Seong-Hwan Hwang, Yongsoo Ra, Somang Paeng, Hyoung F. Kim
Summary: A habitual gaze is crucial for efficiently identifying and exploiting valuable objects. Motivational salience plays a significant role in guiding habitual gaze choices, particularly the preference for negatively valued objects. These habitual choices can facilitate re-learning in a simulated value-forgotten condition.
Article
Neurosciences
Juha Partanen, Kaia Achim
Summary: The Substantia Nigra pars reticulata (SNpr) plays a major role in the basal ganglia network, particularly in movement regulation, behavioral state adjustment, and response to reward. It also has the potential for signal integration and action selection. This article discusses the regionalization of SNpr, specifically the division of its neurons into anterior and posterior subtypes, and how their unique developmental and molecular characteristics may correlate with region-specific connections and functional specializations of SNpr. Understanding the differentiation of SNpr neurons can provide insights into fundamental brain functions and neurological disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Su Hyoun Park, Anne K. Baker, Vinit Krishna, Sean C. Mackey, Katherine T. Martucci
Summary: The brain corticostriatal circuits play a crucial role in understanding chronic pain. In this study, the authors investigated the connectivity of the nucleus accumbens (NAcc) - medial prefrontal cortex (MPFC) circuit in patients with fibromyalgia. They found that the connectivity of this circuit was significantly reduced in fibromyalgia patients compared to healthy controls. The connectivity between the NAcc and subcortical brain regions was also reduced in fibromyalgia. These findings provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
SCIENTIFIC REPORTS
(2022)
Article
Integrative & Complementary Medicine
Chen Limei, Sun Jifei, Guo Chunlei, Li Xiaojiao, Wang Zhi, Hong Yang, Fang Jiliang
Summary: The study shows that transcutaneous auricular vagus nerve stimulation treatment is effective for recurrent depression, with changes in brain functional connectivity providing insight into its effects.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yosuke Sato, Go Okada, Satoshi Yokoyama, Naho Ichikawa, Masahiro Takamura, Yuki Mitsuyama, Ayaka Shimizu, Eri Itai, Hotaka Shinzato, Mitsuo Kawato, Noriaki Yahata, Yasumasa Okamoto
Summary: This study aimed to develop a classifier for subthreshold depression (StD) and explore the underlying neural mechanisms. By using resting-state functional magnetic resonance imaging data, the study identified important functional connections related to StD. Future research should investigate whether modulating these connections can be an effective treatment for StD.
SCIENTIFIC REPORTS
(2023)
Article
Peripheral Vascular Disease
Marieke van den Kerkhof, Merel M. van der Thiel, Alida A. Postma, Robert J. van Oostenbrugge, Abraham A. Kroon, Jacobus F. A. Jansen, Walter H. Backes
Summary: This study found that patients with hypertension have higher pulsatility index (PI) and lower damping factor (DF) in small perforating arteries, which may be due to hypertension-induced arterial stiffening leading to increased blood flow pulsatility and decreased damping. These results highlight the impact of hypertension on cerebral blood vessel structure and function, and provide clues for further investigation into the relationship between hypertension and stroke and cerebral small vessel disease (cSVD).
Article
Acoustics
R. Hagege, K. Krajden Haratz, G. Malinger, L. Ben-Sira, Z. Leibovitz, D. Heron, L. Burglen, R. Birnbaum, S. Valence, B. Keren, L. Blumkin, J. -m. Jouannic, T. Lerman-Sagie, C. Garel
Summary: This retrospective multicenter study aimed to investigate the prenatal diagnosis of mild forms of tubulinopathy and define the ultrasound and MRI features that can facilitate this diagnosis. The main ultrasound criteria included midline distortion, ventricular asymmetry, dysmorphic and/or dilated frontal horn(s), and abnormal sulcation. The main MRI criteria were midline distortion, distortion of the cavum septi pellucidi, ventricular asymmetry, dilatation and/or distortion, dysmorphic and/or dilated frontal horn(s), and abnormal sulcation. Mutations were found in TUBB3, TUBB, TUBB2B, or TUBA1A genes. Most findings could be visualized on ultrasound. The prenatal diagnosis of mild tubulinopathy is challenging but important for prenatal counseling.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Editorial Material
Neurosciences
Marco Leyton
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2018)
Article
Neurosciences
Kelly Smart, Sylvia M. L. Cox, Atsuko Nagano-Saito, Pedro Rosa-Neto, Marco Leyton, Chawki Benkelfat
Article
Behavioral Sciences
Rachel J. Sharkey, Josiane Bourque, Kevin Larcher, Bratislav Misic, Yu Zhang, Ayca Altinkaya, Abbas Sadikot, Patricia Conrod, Alan C. Evans, Hugh Garavan, Marco Leyton, Jean R. Seguin, Robert Pihl, Main Dagher
Article
Clinical Neurology
Daniel E. Vosberg, Vincent Beaule, Angelica Torres-Berrio, Danielle Cooke, Amanda Chalupa, Natalia Jaworska, Sylvia M. L. Cox, Kevin Larcher, Yu Zhang, Dominique Allard, France Durand, Alain Dagher, Chawki Benkelfat, Myriam Srour, Donatella Tampieri, Roberta La Piana, Ridha Joober, Franco Lepore, Guy Rouleau, Alvaro Pascual-Leone, Michael D. Fox, Cecilia Flores, Marco Leyton, Hugo Theoret
ANNALS OF NEUROLOGY
(2019)
Article
Neurosciences
Golia Shafiei, Yashar Zeighami, Crystal A. Clark, Jennifer T. Coull, Atsuko Nagano-Saito, Marco Leyton, Alain Dagher, Bratislav Misic
Article
Radiology, Nuclear Medicine & Medical Imaging
Kelly Smart, Sylvia M. L. Cox, Stephanie G. Scala, Maria Tippler, Natalia Jaworska, Michel Boivin, Jean R. Seguin, Chawki Benkelfat, Marco Leyton
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kelly Smart, Sylvia M. L. Cox, Alexey Kostikov, Aliaksandr Shalai, Stephanie G. Scala, Maria Tippler, Natalia Jaworska, Michel Boivin, Jean R. Seguin, Chawki Benkelfat, Marco Leyton
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Meeting Abstract
Endocrinology & Metabolism
Julian Chiarella, Mari Sild, Kevin F. Casey, Gassan Massarweh, Jean-Paul Soucy, Marco Leyton, Naomi Azar, Richard E. Tremblay, Jacob Hooker, Chawki Benkelfat, Linda Booij
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Biochemical Research Methods
Hussein Bdair, I-Huang Tsai, Kelly Smart, Chawki Benkelfat, Marco Leyton, Alexey Kostikov
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Editorial Material
Neurosciences
Marco Leyton
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Daniel E. Vosberg, Marco Leyton, Cecilia Flores
MOLECULAR PSYCHIATRY
(2020)
Article
Neurosciences
Natalia Jaworska, Sylvia M. L. Cox, Maria Tippler, Natalie Castellanos-Ryan, Chawki Benkelfat, Sophie Parent, Alain Dagher, Frank Vitaro, Michel Boivin, Robert O. Pihl, Sylvana M. Cote, Richard E. Tremblay, Jean R. Seguin, Marco Leyton
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Sylvia M. L. Cox, Maria Tippler, Natalia Jaworska, Kelly Smart, Natalie Castellanos-Ryan, France Durand, Dominique Allard, Chawki Benkelfat, Sophie Parent, Alain Dagher, Frank Vitaro, Michel Boivin, Robert O. Pihl, Sylvana Cote, Richard E. Tremblay, Jean R. Seguin, Marco Leyton
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Jennifer I. Lissemore, Atsuko Nagano-Saito, Kelly Smart, Paul Gravel, Marco Leyton, Chawki Benkelfat
SCIENTIFIC REPORTS
(2020)
Meeting Abstract
Neurosciences
Natalia Jaworska, Sylvia M. L. Cox, Maria Tippler, Natalie Castellanos-Ryan, Chawki Benkelfat, Sophie Parent, Alain Dagher, Frank Vitaro, Michel Boivin, Robert O. Pihl, Sylvana Cote, Richard E. Tremblay, Jean R. Seguin, Marco Leyton
NEUROPSYCHOPHARMACOLOGY
(2019)