Article
Microbiology
Yueyue Duan, Liyan Cao, Cong Yuan, Xuepeng Suo, Xiangyu Kong, Yulong Gao, Xiangtong Li, Haixue Zheng, Xiaomei Wang, Qi Wang
Summary: p53 plays a critical role in inhibiting ALV replication by recruiting the HDAC1/2 complex to the ALV promoter. The acetylation status of ALV-bound histones H3 and H4 correlates with ALV viremia in infected chickens.
Article
Microbiology
Yueyue Duan, Liyan Cao, Cong Yuan, Xuepeng Suo, Xiangyu Kong, Yulong Gao, Xiangtong Li, Haixue Zheng, Xiaomei Wang, Qi Wang
Summary: The research demonstrates that p53 inhibits ALV replication by recruiting the HDAC1/2 complex to the ALV promoter, and the absence of p53 abolishes HDAC1/2 binding to the ALV promoter. Clinical samples from ALV-infected chickens show that the acetylation status of ALV-bound H3 and H4 histones correlates with ALV viremia.
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Fan Zhang, Bingying Lin, Siyu Huang, Pengsen Wu, Min Zhou, Jing Zhao, Xiangqing Hei, Yu Ke, Yiting Zhang, Danping Huang
Summary: Retinal ischemia-reperfusion (RIR) injury caused by high intraocular pressure (IOP) leads to retinal ganglion cell (RGC) death and eventually blindness. Ferroptosis, a form of programmed cell death, is involved in RGC death. Melatonin (MT) shows neuroprotective effects against RIR injury by inhibiting p53-mediated ferroptosis.
Article
Biochemistry & Molecular Biology
Ofira Zloto, Alon Zahavi, Stephen Richard, Moran Friedman-Gohas, Shirel Weiss, Nitza Goldenberg-Cohen
Summary: This study evaluated the potential neuroprotective effect of azithromycin injections in mice with optic nerve crush. The results showed that azithromycin reduced apoptosis and improved the preservation of retinal ganglion cells. It also decreased microglial activation and modulated inflammatory reactions. These findings suggest that azithromycin may have a role in preserving retinal ganglion cells after optic neuropathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xiaohong Xiang, Guie Dong, Jiefu Zhu, Gang Zhang, Zheng Dong
Summary: This study reveals the pathogenic role of HDAC3 in cold storage/rewarming injury in kidney transplantation. Selective inhibition of HDAC3 can reduce acute tubular injury and cell death after prolonged cold storage, and improve renal function and tubular integrity. In vitro experiments also show that HDAC3 inhibition can suppress cell death induced by cold storage and rewarming of proximal tubular cells.
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Svetlana Sharifulina
Summary: HDAC and HAT play crucial roles in regulating cell functions through acetylating/deacetylating histones and non-histone proteins, impacting cell survival, death, and other processes. The effects of stroke on non-histone protein acetylation/deacetylation in brain cells are still poorly understood, but HDAC inhibitors have shown promise in protecting the brain from ischemic damage. The roles of different HDAC isoforms in brain cell survival and death after stroke remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yudibeth Sixto-Lopez, Jose Antonio Gomez-Vidal, Nuria de Pedro, Martiniano Bello, Martha Cecilia Rosales-Hernandez, Jose Correa-Basurto
Summary: HDAC6 has been identified as a molecular target for treating neurodegenerative disorders. Through a combination of computational design, molecular docking, and in vitro testing, a lead compound and a second series of compounds with improved neuroprotective effects were identified. The study highlights the potential of these compounds as HDAC6 inhibitors with neuroprotective properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Ophthalmology
Jing Zhao, Graydon Gonsalvez, Manuela Bartoli, Barbara A. Mysona, Sylvia B. Smith, Kathryn E. Bollinger
Summary: The study evaluated the ability of S1R to modulate reactivity responses of optic nerve head astrocytes (ONHAs) and found that S1R activation enhanced ONHA reactivity characteristics, which may have important implications for the survival of retinal ganglion cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yi-Fen Lai, Ting-Yi Lin, Pin-Kuan Ho, Yi-Hao Chen, Yu-Chuan Huang, Da-Wen Lu
Summary: In this review, the neuroprotective function of erythropoietin (EPO) in extra-hematopoietic tissues, especially the retina, is highlighted. The available pre-clinical studies of EPO in treating various optic neuropathies are summarized. Furthermore, future strategies for optic nerve protection and repair using EPO and its derivatives are explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Gaurav Sarode, Kari Neier, Noreene M. Shibata, Yuanjun Shen, Dmitry A. Goncharov, Elena A. Goncharova, Tagreed A. Mazi, Nikhil Joshi, Matthew L. Settles, Janine M. LaSalle, Valentina Medici
Summary: The study reveals that the pathogenesis of Wilson disease involves copper accumulation in the liver and brain, affecting acetylation levels through changes in histone deacetylase 5. Dietary modulation can regulate the acetylation levels of HDAC4/5 and H3K9/H3K27.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Clinical Neurology
V. V. Guzenko, S. S. Bachurin, A. M. Khaitin, V. A. Dzreyan, Y. N. Kalyuzhnaya, He Bin, S. V. Demyanenko
Summary: The expression and acetylation of p53 are important for the survival and death of neurons in the penumbra region. The regulation of p53 acetylation at lysine 320 by PCAF, HDAC1, and HDAC6 influences the shuttling of p53 between the nucleus and cytoplasm in penumbra neurons. Acetylation of p53 at lysine 320 may promote the survival and repair of neurons in the penumbra after stroke, suggesting potential therapeutic strategies for stroke recovery by targeting p53 acetylation.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Reproductive Biology
Satoshi Kamimura, Kimiko Inoue, Eiji Mizutani, Jin-Moon Kim, Hiroki Inoue, Narumi Ogonuki, Kei Miyamoto, Shunya Ihashi, Nobuhiko Itami, Teruhiko Wakayama, Akihiro Ito, Norikazu Nishino, Minoru Yoshida, Atsuo Ogura
Summary: The study found that using chlamydocin analogues, which specifically inhibit I and IIa class HDACs, can improve the efficiency of mouse SCNT, with Ky-9 showing similar results to trichostatin A. The one-cell stage was identified as a critical period for enhancing cloning through the use of HDAC inhibitors in SCNT.
BIOLOGY OF REPRODUCTION
(2021)
Article
Neurosciences
Luxi Wang, Ling Liu, Chao Han, Haiyang Jiang, Kai Ma, Shiyi Guo, Yun Xia, Fang Wan, Jinsha Huang, Nian Xiong, Tao Wang
Summary: The study found that HDAC4 is highly expressed in the brain tissues of Parkinson's disease (PD) patients. The inhibition of HDAC4 by mc1568 can reduce the levels of alpha-synuclein and activate autophagy in brain cells. These findings suggest that HDAC4 may be a potential therapeutic target for PD.
Article
Biochemistry & Molecular Biology
Sylvain Lamoine, Melissa Cumenal, David A. Barriere, Vanessa Pereira, Mathilde Fereyrolles, Laetitia Prival, Julie Barbier, Ludivine Boudieu, Emilie Brasset, Benjamin Bertin, Yoan Renaud, Elisabeth Miot-Noirault, Marie-Ange Civiale, David Balayssac, Youssef Aissouni, Alain Eschalier, Jerome Busserolles
Summary: This study found that MS-275 can prevent oxaliplatin-induced peripheral neuropathy and has anti-tumor activity in colorectal cancer. Experimental evidence from mice and human cell lines showed that the combination of MS-275 and oxaliplatin synergistically inhibits tumor proliferation and improves survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Daniel R. Margevicius, Chinthasagar Bastian, Qingyuan Fan, Roger J. Davis, Sanjay W. Pimplikar
NEUROBIOLOGY OF AGING
(2015)
Article
Cell Biology
Xinghua Yin, Grahame J. Kidd, Nobuhiko Ohno, Guy A. Perkins, Mark H. Ellisman, Chinthasagar Bastian, Sylvain Brunet, Selva Baltan, Bruce D. Trapp
JOURNAL OF CELL BIOLOGY
(2016)
Article
Neurosciences
Katharine E. Stahon, Chinthasagar Bastian, Shelby Griffith, Grahame J. Kidd, Sylvain Brunet, Selva Baltan
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Chinthasagar Bastian, Jane Zaleski, Katharine Stahon, Brandon Parr, Andrew McCray, Jerica Day, Sylvain Brunet, Selva Baltan
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Chinthasagar Bastian, John Quinn, Ajai Tripathi, Danielle Aquila, Andrew McCray, Ranjan Dutta, Selva Baltan, Sylvain Brunet
NEUROBIOLOGY OF DISEASE
(2019)
Article
Neurosciences
Chinthasagar Bastian, Yang V. Li
NEUROSCIENCE LETTERS
(2007)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)