Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Xilei Xie, Yawen Liu, Guangzhao Liu, Yuying Zhao, Jinyan Liu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang, Bo Tang
Summary: In this study, a novel fluorescent probe was designed and synthesized, allowing the visualization of the crucial role of peroxynitrite in Alzheimer's disease through in vivo experiments in mice.
CHEMICAL COMMUNICATIONS
(2022)
Article
Ophthalmology
Tadanobu Yoshikawa, Kenji Obayashi, Kimie Miyata, Keigo Saeki, Nahoko Ogata
Summary: The study revealed a significant association between higher serum ADMA levels and severe glaucoma, which remained significant after adjusting for potential confounders.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Juan A. Godoy, Juvenal A. Rios, Pol Picon-Pages, Victor Herrera-Fernandez, Bronte Swaby, Giulia Crepin, Ruben Vicente, Jose M. Fernandez-Fernandez, Francisco J. Munoz
Summary: Mitochondria play critical roles in neurons by regulating neurotransmission and synaptic plasticity through ATP supply, calcium homeostasis, redox balance control, and apoptosis. Their functional integrity is mainly maintained by mitostasis, involving processes like mitochondrial transport, anchoring, fusion, and fission, regulated by various signaling pathways. The communication between mitochondria and the endoplasmic reticulum (ER) via mitochondria-associated membranes (MAMs) is crucial for Ca2+ buffering. Alterations in mitochondrial activity can lead to increased production of reactive oxygen species, disturbance in physiological metabolism, and mitochondrial dysfunction resulting in cell death through apoptosis.
Article
Biochemistry & Molecular Biology
Elena Grossini, Divya Garhwal, Sakthipriyan Venkatesan, Daniela Ferrante, Angelica Mele, Massimo Saraceno, Ada Scognamiglio, Jessica Mandrioli, Amedeo Amedei, Fabiola De Marchi, Letizia Mazzini
Summary: This study analyzed the plasma redox system and nitric oxide levels in ALS patients and investigated the effects of plasma on mitochondrial function in endothelial vascular cells and astrocytes. The results showed that oxidative stress and neurovascular unit changes play a central role in ALS, and unknown plasma factors may be involved in the disease pathogenesis.
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lei Zhao, Cheng-Lin Zhang, Lei He, Qinghua Chen, Limei Liu, Lijing Kang, Jian Liu, Jiang-Yun Luo, Lingshan Gou, Dan Qu, Wencong Song, Chi Wai Lau, Ho Ko, Vincent C. T. Mok, Xiao Yu Tian, Li Wang, Yu Huang
Summary: Monomerization and uncoupling of eNOS play crucial roles in mediating vascular dysfunction in diabetes. This study reveals that impaired autophagic flux leads to eNOS monomerization and reduced nitric oxide bioavailability in diabetic mice. Restoring autophagic flux improves endothelial cell oxidative stress, promotes eNOS dimerization, and enhances endothelium-dependent relaxations in diabetic mice.
Article
Chemistry, Multidisciplinary
Fang Yuan, Cuiling Zhang, Xianzhu Luo, Xiaokun Shen, Yuezhong Xian
Summary: ATP stimulus-responsive tetrahedral DNA-gated fluorescent covalent organic frameworks (COFs) were developed for estradiol (E2) delivery and controllable release. The fluorescent COFs with an efficient E2 loading showed great potential against myocardial ischemia and reperfusion injury.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Tian Hao, Meng Qian, Yating Zhang, Qi Liu, Adam C. Midgley, Yangping Liu, Yongzhe Che, Jingli Hou, Qiang Zhao
Summary: Acute myocardial infarction is the leading cause of death worldwide. Researchers have synthesized a hydrogel that can release nitric oxide to modulate ROS/NO imbalance after ischemia/reperfusion injury, effectively alleviating cardiac damage and improving cardiac function. The hydrogel protects against oxidative stress by activating the antioxidant defense system and reducing inflammation.
Article
Peripheral Vascular Disease
Matthew J. Rossman, Rachel A. Gioscia-Ryan, Jessica R. Santos-Parker, Brian P. Ziemba, Kara L. Lubieniecki, Lawrence C. Johnson, Natalie E. Poliektov, Nina Z. Bispham, Kayla A. Woodward, Erzsebet E. Nagy, Nathan S. Bryan, Julie A. Reisz, Angelo D'Alessandro, Michel Chonchol, Amy L. Sindler, Douglas R. Seals
Summary: Inorganic nitrite supplementation improves endothelial function in older adults by increasing NO, decreasing mitochondrial reactive oxygen species/oxidative stress, and increasing mitochondrial stress resistance.
Review
Biochemistry & Molecular Biology
Paulina Bastian, Jaroslaw Dulski, Anna Roszmann, Dagmara Jacewicz, Alicja Kuban-Jankowska, Jaroslaw Slawek, Michal Wozniak, Magdalena Gorska-Ponikowska
Summary: Mitochondria, known as the power house of the cell, play crucial roles in cell pathophysiology, participating in various physiological activities. Dysregulation of mitochondrial dynamics may lead to the development of diseases. 2-methoxyestradiol (2-ME) has the potential to affect cell growth and mitochondrial function by inhibiting nitric oxide synthase (NOS) production and oxidative stress.
Article
Chemistry, Medicinal
Jashanpreet Kaur, Tajpreet Kaur, Ashwani Kumar Sharma, Japneet Kaur, Harlokesh Narayan Yadav, Devendra Pathak, Amrit Pal Singh
Summary: Fenofibrate attenuates I/R-induced AKI and associated hepatic dysfunction potentially through modulation of eNOS expression.
DRUG DEVELOPMENT RESEARCH
(2021)
Article
Plant Sciences
Neha Gupta, Arun Kumar Mishra
Summary: NOS-derived NO plays a critical role in protecting cyanobacteria from oxidative burst and maintaining their physiological balance. Addition of L-NAME inhibitor reduces NO accumulation, while addition of L-arginine increases NO synthesis. Inhibition of NOS leads to decreased growth and metabolic activity of cyanobacteria, as well as decline in photopigments, PSII efficiency, loss in membrane integrity and DNA damage, ultimately resulting in cell death.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Gensheng Zhang, Huirong Han, Zhengbing Zhuge, Fang Dong, Shan Jiang, Wenwen Wang, Drielle D. Guimaraes, Tomas A. Schiffer, En Yin Lai, Lucas Rannier Ribeiro Antonino Carvalho, Ricardo Barbosa Lucena, Valdir A. Braga, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: Boosting the nitrate-nitrite-NO pathway shows therapeutic potential in ameliorating renal and cardiovascular dysfunction induced by renal ischemia-reperfusion injury, reducing oxidative stress and injuries.
Article
Geriatrics & Gerontology
Daniel R. Margevicius, Chinthasagar Bastian, Qingyuan Fan, Roger J. Davis, Sanjay W. Pimplikar
NEUROBIOLOGY OF AGING
(2015)
Article
Cell Biology
Xinghua Yin, Grahame J. Kidd, Nobuhiko Ohno, Guy A. Perkins, Mark H. Ellisman, Chinthasagar Bastian, Sylvain Brunet, Selva Baltan, Bruce D. Trapp
JOURNAL OF CELL BIOLOGY
(2016)
Article
Neurosciences
Katharine E. Stahon, Chinthasagar Bastian, Shelby Griffith, Grahame J. Kidd, Sylvain Brunet, Selva Baltan
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Chinthasagar Bastian, John Quinn, Ajai Tripathi, Danielle Aquila, Andrew McCray, Ranjan Dutta, Selva Baltan, Sylvain Brunet
NEUROBIOLOGY OF DISEASE
(2019)
Article
Biochemistry & Molecular Biology
Sean P. Murphy, Rona J. Lee, Megan E. McClean, Heather E. Pemberton, Takuma Uo, Richard S. Morrison, Chinthasagar Bastian, Selva Baltan
JOURNAL OF NEUROCHEMISTRY
(2014)
Review
Neurosciences
Selva Baltan, Chinthasagar Bastian, John Quinn, Danielle Aquila, Andrew McCray, Sylvain Brunet
NEUROSCIENCE LETTERS
(2018)
Article
Neurosciences
Chinthasagar Bastian, Yang V. Li
NEUROSCIENCE LETTERS
(2007)