15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) protects neurons from oxidative death via an Nrf2 astrocyte-specific mechanism independent of PPARγ

Palm Oil–Derived Natural Vitamin E α-Tocotrienol in Brain Health and Disease

(2013) Chandan K Sen et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Role of NF-κB in the Anti-Inflammatory Effects of Tocotrienols

(2013) Mary Kaileh et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Synergistic Effect of Cyanidin and PPAR Agonist against Nonalcoholic Steatohepatitis-Mediated Oxidative Stress-Induced Cytotoxicity through MAPK and Nrf2 Transduction Pathways

(2012) Ping-Hsiao Shih et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The omega-6 fatty acid derivative 15-deoxy-Δ12,14-prostaglandin J2 is involved in neuroprotection by enteric glial cells against oxidative stress

(2012) Hind Abdo et al.   JOURNAL OF PHYSIOLOGY-LONDON

15-Deoxy-Δ12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling

(2011) Young-Joon Surh et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2-regulated PPARγ Expression Is Critical to Protection against Acute Lung Injury in Mice

(2010) Hye-Youn Cho et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages

(2010) Mansoor Ali Syed et al.   EXPERIMENTAL CELL RESEARCH

Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases

(2010) Moonhee Lee et al.   FASEB JOURNAL

Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes Their Transcriptional Repressor Function

(2010) Kelly Doyle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15d-Prostaglandin J2 Enhancement of Nerve Growth Factor–Induced Neurite Outgrowth Is Blocked by the Chemoattractant Receptor– Homologous Molecule Expressed on T-Helper Type 2 Cells (CRTH2) Antagonist CAY10471 in PC12 Cells

(2010) Michiyoshi Hatanaka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Vitamin E and neurological function

(2010) David P. R. Muller   MOLECULAR NUTRITION & FOOD RESEARCH

Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1

(2010) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reply to Bell et al.: Nrf2-dependent and -independent mechanisms of astrocytic neuroprotection

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning

(2010) K. F. Bell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway

(2010) R. E. Haskew-Layton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Regulation of Nrf2-dependent gene expression by 15-deoxy-Δ12,14-prostaglandin J2

(2009) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuronal PPAR  Deficiency Increases Susceptibility to Brain Damage after Cerebral Ischemia

(2009) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Amyloid- 42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism

(2009) S. D. Ryan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Accumulation of 15-deoxy-Δ12,14-prostaglandin J2adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction

(2008) Joo Yeun Oh et al.   BIOCHEMICAL JOURNAL

15-Deoxy-Δ12,14-prostaglandin J2 rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: Potential roles of Akt and ERK1/2

(2008) Ji-Woo Kim et al.   BIOCHEMICAL PHARMACOLOGY

The protective effects of 15-deoxy-Δ-12,14-prostaglandin J2 in spinal cord injury

(2008) Bradley J. Kerr et al.   GLIA

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

(2008) T. Yamamoto et al.   MOLECULAR AND CELLULAR BIOLOGY

The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

(2008) M. Kobayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease

(2008) Ben A. Barres   NEURON

Peroxisome Proliferator-Activated Receptor-γin Amyotrophic Lateral Sclerosis and Huntington’s Disease

(2008) Mahmoud Kiaei   PPAR Research

Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

(2007) Ramya Kapadia   Frontiers in Bioscience-Landmark

The peroxisome proliferator-activated receptor-γ agonist 1,1-bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells

(2007) Ronald B. Tjalkens et al.   JOURNAL OF NEUROSCIENCE RESEARCH