Article
Immunology
Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh
Summary: 15d-PGJ(2) promotes the resolution of intestinal colitis by reducing neutrophils and M1 macrophages, increasing M2 macrophage proportion, and decreasing the expression of pro-inflammatory cytokine IL-6 in macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Eun-Hee Kim, Su-Jung Kim, Hye-Kyung Na, Wonshik Han, Nam-Jung Kim, Young-Ger Suh, Young-Joon Surh
Summary: The study found that 15d-PGJ2 activates VEGF expression through NRF2-driven induction of HO-1 in human breast cancer cells, suggesting a novel oncogenic mechanism. Elevated levels of 15d-PGJ2 during the inflammatory response were linked to poor clinical outcomes in breast cancer patients. Levels of 15d-PGJ2, COX-2, NRF2, and HO-1 were found to be increased in human breast cancer tissues.
Article
Engineering, Biomedical
Yao Jiang, Jia-Mei Liu, Jia-Ping Huang, Ke-Xi Lu, Wei-Lian Sun, Jing-Yi Tan, Bo-Xiu Li, Li-Li Chen, Yan-Min Wu
Summary: This study evaluated the biological properties of decellularized human periodontal ligament cell (dHPDLC) sheets in vitro, showing that dHPDLC sheets can promote periodontal regeneration in an inflammatory environment.
BIOMEDICAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Su-Jung Kim, Nam-Chul Cho, Bitnara Han, Kyeojin Kim, Young-Il Hahn, Kwang Pyo Kim, Young Ger Suh, Bu Young Choi, Hye-Kyung Na, Young-Joon Surh
Summary: The cyclopentenone prostaglandin 15d-PGJ2 functions as an allosteric inhibitor of STAT3 by covalently modifying STAT3 on Cys259, inhibiting its activity in MCF10A-Ras cells. This results in antiproliferative and pro-apoptotic effects similar to mutation of this amino acid.
Article
Chemistry, Multidisciplinary
Airat M. Gimazetdinov, Aidar Z. Al'mukhametov, Mansur S. Miftakhov
Summary: An asymmetric total synthesis of 15-deoxy-Delta(12,14)-prostaglandin J(2) methyl ester is described. The synthesis involves several key steps, including the formation of a cyclopentenone precursor, construction of the prostaglandin alpha-chain, and alkylation followed by the formation of the omega-chain.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Immunology
Weiyang Li, Jieshi Xie, Le Yang, Yuanru Yang, Lin Yang, Liying Li
Summary: The study found that 15d-PGJ2 can reduce MIF expression in damaged hepatocytes by activating PPARγ, thereby inhibiting macrophage infiltration and inflammatory response, ultimately alleviating acute liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nikolay S. Vostrikov, Vadim V. Zagitov, Alexander N. Lobov, Diana Ishmetova, Yulia V. Vakhitova, Mansur S. Miftakhov
Summary: A series of novel compounds were synthesized through multiple steps in this study, and their anticancer activities were preliminarily explored.
Article
Immunology
Yuping Ning, Wenfei Wang, Paul M. Jordan, Stefanie A. Barth, Robert Klaus Hofstetter, Jinjin Xu, Ximeng Zhang, Yi Cai, Christian Menge, Xinchun Chen, Oliver Werz
Summary: Tuberculosis caused by Mycobacterium tuberculosis is a global health concern. In this study, it is shown that M. tuberculosis induces COX-2 expression in human macrophages and promotes the formation of anti-inflammatory J2-PGs. These J2-PGs have anti-inflammatory effects in M1-MDMs, downregulating proinflammatory cytokines and upregulating anti-inflammatory cytokines and M2 markers.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zaynutdin R. Makaev, Nikolay S. Vostrikov, Natalya K. Selezneva, Mansur S. Miftakhov
Summary: A simple and efficient synthesis of racemic 15-deoxy- increment 12,14- prostaglandin J2 methyl ester from readily available Corey lactone diol in a total of eleven steps was proposed. Standard methods were used to form a fused co-chain and then converted into PGJ2 methyl ester. The transformation to the target prostaglandin was achieved smoothly in TsOH-CH2Cl2 medium by converting the allylic alcohol moiety to an exocyclic diene substituent conjugated with the endocyclic enone system.
MENDELEEV COMMUNICATIONS
(2023)
Article
Cell Biology
Clovis M. Kumagai, Renata M. Martinez, Barbara B. Colombo, Priscila Saito, Ingrid C. Pinto, Camilla C. A. Rodrigues, David L. Vale, Ricardo L. N. Matos, Ana P. F. R. L. Bracarense, Marcela M. Baracat, Sandra R. Georgetti, Juliana T. Clemente-Napimoga, Marcelo H. Napimoga, Victor Fattori, Waldiceu A. Verri, Rubia Casagrande
Summary: UVB radiation poses a significant threat to the skin, and topical administration of 15-Deoxy-Delta(12,14)-prostaglandin J(2) shows promise in mitigating UVB-induced skin damage. The study suggests that TFcPGJ(2) has therapeutic potential in combating inflammatory and oxidative skin pathologies caused by UVB exposure.
MEDIATORS OF INFLAMMATION
(2021)
Article
Oncology
Su-Jung Kim, Nam-Chul Cho, Young-Il Hahn, Seong Hoon Kim, Xizhu Fang, Young-Joon Surh
Summary: 15d-PGJ(2) inhibits STAT3 signaling and induces apoptosis in human breast tumor cells, particularly effective in triple negative breast cancer cells but less effective in estrogen receptor positive breast cancer cells. This compound may offer a potential therapeutic approach for the treatment of triple negative breast cancer through direct chemical modification of STAT3.
JOURNAL OF CANCER PREVENTION
(2021)
Article
Endocrinology & Metabolism
Zahirrah BM. Rasheed, Yun S. S. Lee, Sung H. H. Kim, Tg Teoh, David A. A. MacIntyre, Phillip R. R. Bennett, Lynne Sykes
Summary: The study found that 15dPGJ2 has differential effects on inflammatory modulation depending on cell type, and is therefore unlikely to be a useful therapeutic agent for the prevention of preterm birth.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Maria Kalogerou, Sotiris Ioannou, Panagiotis Kolovos, Ekatherine Prokopiou, Louiza Potamiti, Kyriacos Kyriacou, Michail Panagiotidis, Maria Ioannou, Eleni Fella, Elena Panayiotou Worth, Tassos Georgiou
Summary: The study evaluated the neuroprotective effects of ω-3 PUFAs in a mouse model of ADOA, showing that supplementation had protective effects on retinas through inhibition of inflammation and apoptosis. The findings also suggest that ω-3 PUFAs may not be involved in neuroprotection through inhibition of oxidative stress.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Toxicology
Ahmed Ayyash, Alison C. Holloway
Summary: Fluoxetine, a commonly used SSRI antidepressant, has been found to increase the risk of metabolic diseases such as nonalcoholic fatty liver disease. It affects hepatic lipid accumulation and the production of prostaglandins, which are implicated in the development of liver diseases. Understanding these mechanisms could lead to novel therapeutic strategies to mitigate the adverse effects of fluoxetine treatment.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carl Eguez, Michelle A. Clark, Ann Tenneil O'Connor
Summary: 15-Deoxy-Delta-(12,14)-prostaglandin J2 (15d-PGJ2) has inhibitory effects on proliferation and alters protein expression in vascular smooth muscle cells (VSMCs). Controversy exists over whether it induces PPAR-γ activation, but understanding the mechanisms by which it elicits beneficial actions can aid in developing new therapeutic strategies.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2021)
Correction
Cell & Tissue Engineering
Jorge O. Munera, Nambirajan Sundaram, Scott A. Rankin, David Hill, Carey Watson, Maxime Mahe, Jefferson E. Vallance, Noah F. Shroyer, Katie L. Sinagoga, Adrian Zarzoso-Lacoste, Jonathan R. Hudson, Jonathan C. Howell, Praneet Chatuvedi, Jason R. Spence, John M. Shannon, Aaron M. Zorn, Michael A. Helmrath, James M. Wells
Article
Allergy
Taeko K. Noah, Kathryn A. Knoop, Keely G. McDonald, Jenny K. Gustafsson, Lisa Waggoner, Simone Vanoni, Matthew Batie, Kavisha Arora, Anjaparavanda P. Naren, Yui-Hsi Wang, Nicholas W. Lukacs, Ariel Munitz, Michael A. Helmrath, Maxime M. Mahe, Rodney D. Newberry, Simon P. Hogan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Review
Medicine, Research & Experimental
Charlotte Flatres, Elise Loffet, Michel Neunlist, Maxime M. Mahe
M S-MEDECINE SCIENCES
(2019)
Article
Multidisciplinary Sciences
Hind Abdo, Laura Calvo-Enrique, Jose Martinez Lopez, Jianren Song, Ming-Dong Zhang, Dmitry Usoskin, Abdeljabbar El Manira, Igor Adameyko, Jens Hjerling-Leffler, Patrik Ernfors
Article
Oncology
Daniela Leonetti, Hala Estephan, Natacha Ripoche, Nolwenn Dubois, Audrey Aguesse, Sebastien Gouard, Lisa Brossard, Sophie Chiavassa, Isabelle Corre, Claire Pecqueur, Michel Neunlist, Elie Hadchity, Marie-Helene Gaugler, Maxime M. Mahe, Francois Paris
Article
Gastroenterology & Hepatology
Camille Pochard, Jacques Gonzales, Anne Bessard, Maxime M. Mahe, Arnaud Bourreille, Nicolas Cenac, Anne Jarry, Emmanuel Coron, Juliette Podevin, Guillaume Meurette, Michel Neunlist, Malvyne Rolli-Derkinderen
Summary: This study identified a PGI(2) defect in the intestinal mucosa of IBD patients and demonstrated its protective role during colitis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Cell Biology
Alexane Ollivier, Maxime M. Mahe, Geraldine Guasch
Summary: The gastrointestinal tract is a continuous series of organs allowing digestion, frequently affected by chronic stress and injury, leading to tissue regeneration and disease risks. Human 3D organoid culture systems provide potential applications in understanding cellular and molecular mechanisms in epithelial wound healing. Organoid models are useful in analyzing human gastrointestinal disease mechanisms, with perspectives on regenerative therapy to improve epithelial barrier repair.
Review
Biochemistry & Molecular Biology
Musa Idris, Maria M. Alves, Robert M. W. Hofstra, Maxime M. Mahe, Veerle Melotte
Summary: Modeling colorectal cancer using organoids has rapidly advanced in the past decade, providing valuable insights into the development and treatment options for this type of cancer. Emphasis is placed on the importance of tumor microenvironment in CRC modeling, and the potential of CRC organoids derived from pluripotent stem cells in cancer research is also discussed.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Immunology
Fatina Siwczak, Elise Loffet, Mathilda Kaminska, Hristina Koceva, Maxime M. Mahe, Alexander S. Mosig
Summary: The article discusses the anatomical structure and biological functions of the gut, introduces the method of using organ-on-chip technology for research, and discusses the latest developments and future research directions on intestinal stem cell differentiation, tissue formation, and the interaction of the gut with the microbiota.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Mayra Aguirre Garcia, Killian Hillion, Jean-Michel Cappelier, Michel Neunlist, Maxime M. Mahe, Nabila Haddad
Summary: Foodborne diseases cause significant morbidity and mortality globally. Understanding the interactions between bacteria and epithelial cells during infection is crucial for prevention and treatment. Traditional cell cultures have limitations, and the development of organoids has provided new insights into studying microbial infections and controlling foodborne hazards.
Editorial Material
Biochemical Research Methods
Killian Hillion, Maxime M. Mahe
Summary: OCTOPUS is a bioengineered device used for long-term high-fidelity organoid cultures.
Article
Gastroenterology & Hepatology
Florence Blot, Justine Marchix, Miriam Ejarque, Sara Jimenez, Aline Meunier, Celine Keime, Camille Trottier, Mikael Croyal, Celine Lapp, Maxime M. Mahe, Adele De Arcangelis, Gerard Gradwohl
Summary: EECs play a crucial role in regulating energy homeostasis by sensing luminal nutrients and microbial metabolites. The absence of EECs in healthy adult mice leads to weight loss, impaired lipid absorption and metabolism, and altered gut microbiota composition.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Remi Duclaux-Loras, Corinne Lebreton, Jeremy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, Celine Revenu de Courtils, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Julia Baptista, Maxime M. Mahe, Michael W. Hess, Beatrice Durel, Nathalie Lefort, Celine Banal, Melanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Mueller, Lukas A. Huber, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Filippo Del Bene, Gregoire Michaux, Nadine Cerf-Bensussan, Marianna Parlato
Summary: Variants in the UNC45A cochaperone can cause a syndrome with symptoms including diarrhea, cholestasis, deafness, and bone fragility. This study provides evidence that UNC45A plays a crucial role in epithelial morphogenesis and its loss can lead to a variant of microvillus inclusion disease.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Cell Biology
Elise Loffet, Lisa Brossard, Maxime M. Mahe
HUMAN PLURIPOTENT STEM CELL DERIVED ORGANOID MODELS
(2020)
Article
Gastroenterology & Hepatology
Nina G. Steele, Jayati Chakrabarti, Jiang Wang, Jacek Biesiada, Loryn Holokai, Julie Chang, Lauren M. Nowacki, Jennifer Hawkins, Maxime Mahe, Nambirajan Sundaram, Noah Shroyer, Mario Medvedovic, Michael Helmrath, Syed Ahmad, Yana Zavros
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2019)