Bapineuzumab Alters Aβ Composition: Implications for the Amyloid Cascade Hypothesis and Anti-Amyloid Immunotherapy

Molecular mechanisms of beta-amyloid misfolding and aggregation: Insights from experiments and theory

(2012) Yuliang Zhang et al.   Alzheimers & Dementia

Hypertension increases tau hyperphosphorylation and beta-amyloid production in pigs

(2012) Yu-Min Kuo et al.   Alzheimers & Dementia

Spontaneous ARIA-E and ARIA-H in Aged APP+PS1 Mice

(2012) James Goodman et al.   Alzheimers & Dementia

Spontaneous amyloid-related imaging abnormalities of the microhemorrage and effusive/edematous types in aged APP+ presenilin 1 mice

(2012) James Goodman et al.   Alzheimers & Dementia

Effect of Immunotherapy With Bapineuzumab on Cerebrospinal Fluid Biomarker Levels in Patients With Mild to Moderate Alzheimer Disease

(2012) Henrik Zetterberg   ARCHIVES OF NEUROLOGY

Does vascular pathology contribute to Alzheimer changes?

(2012) Raj N. Kalaria et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis

(2012) Reisa Sperling et al.   LANCET NEUROLOGY

Staging and Natural History of Cerebrovascular Pathology in Dementia

(2012) V. Hachinski et al.   NEUROLOGY

Interactions between Amyloid-β and Hemoglobin: Implications for Amyloid Plaque Formation in Alzheimer's Disease

(2012) Jia-Ying Chuang et al.   PLoS One

Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer’s disease study cohorts from phase 3 trials of semagacestat and solanezumab

(2011) Christopher Carlson et al.   Alzheimers & Dementia

Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: Recommendations from the Alzheimer’s Association Research Roundtable Workgroup

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Is Alzheimer’s disease amyloidosis the result of a repair mechanism gone astray?

(2011) Tyler A. Kokjohn et al.   Alzheimers & Dementia

Single-Molecule Atomic Force Microscopy Force Spectroscopy Study of Aβ-40 Interactions

(2011) Bo-Hyun Kim et al.   BIOCHEMISTRY

Stoichiometry and Affinity of the Human Serum Albumin-Alzheimer's Aβ Peptide Interactions

(2011) Julijana Milojevic et al.   BIOPHYSICAL JOURNAL

Alzheimer's disease & metals: therapeutic opportunities

(2011) Vijaya B Kenche et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibody-based therapy in Alzheimer's disease

(2011) Refik Pul et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The role of metallobiology and amyloid-β peptides in Alzheimer’s disease

(2011) Blaine R. Roberts et al.   JOURNAL OF NEUROCHEMISTRY

Frontal Cortex Neuropathology in Dementia Pugilistica

(2011) Tommy Saing et al.   JOURNAL OF NEUROTRAUMA

Interactions of Zn(ii) and Cu(ii) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

(2011) Vello Tõugu et al.   Metallomics

Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging

(2011) Chera L. Maarouf et al.   PLoS One

Neuropathology after active Aβ42 immunotherapy: implications for Alzheimer’s disease pathogenesis

(2010) Delphine Boche et al.   ACTA NEUROPATHOLOGICA

A Single Ascending Dose Study of Bapineuzumab in Patients With Alzheimer Disease

(2010) Ronald S. Black et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Brain Endothelial Cells Synthesize Neurotoxic Thrombin in Alzheimer’s Disease

(2010) Xiangling Yin et al.   AMERICAN JOURNAL OF PATHOLOGY

Beneficial effect of human anti-amyloid-β active immunization on neurite morphology and tau pathology

(2010) Alberto Serrano-Pozo et al.   BRAIN

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

(2010) C. R. Jack et al.   BRAIN

Functional, Global and Cognitive Decline Correlates to Accumulation of Alzheimers Pathology in MCI and AD

(2010) M.N. Sabbagh et al.   Current Alzheimer Research

Bapineuzumab

(2010) Geoffrey A Kerchner et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Immunotherapy for Alzheimer’s disease

(2010) D. Morgan   JOURNAL OF INTERNAL MEDICINE

Magnetic Resonance Imaging Detection and Time Course of Cerebral Microhemorrhages during Passive Immunotherapy in Living Amyloid Precursor Protein Transgenic Mice

(2010) F. Luo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

The biochemical aftermath of anti-amyloid immunotherapy

(2010) Chera L Maarouf et al.   Molecular Neurodegeneration

Role of Vascular Risk Factors and Vascular Dysfunction in Alzheimer's Disease

(2010) Dara L. Dickstein et al.   MOUNT SINAI JOURNAL OF MEDICINE

Blood–brain barrier breakdown as a therapeutic target in traumatic brain injury

(2010) Dan Shlosberg et al.   Nature Reviews Neurology

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury

(2010) S. Nag et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Vascular basis for brain degeneration: faltering controls and risk factors for dementia

(2010) Raj N Kalaria   NUTRITION REVIEWS

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoimaging for protein misfolding diseases

(2010) Yuri L. Lyubchenko et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations

(2009) Miguel A. Gama Sosa et al.   AMERICAN JOURNAL OF PATHOLOGY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Antibody Responses, Amyloid-β Peptide Remnants and Clinical Effects of AN-1792 Immunization in Patients with AD in an Interrupted Trial

(2009) Tyler Kokjohn et al.   CNS & Neurological Disorders-Drug Targets

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

Consequence of Aβ immunization on the vasculature of human Alzheimer's disease brain

(2008) D. Boche et al.   BRAIN

The Sun Health Research Institute Brain Donation Program: Description and Eexperience, 1987–2007

(2008) Thomas G. Beach et al.   CELL AND TISSUE BANKING

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

(2008) Chera L Maarouf et al.   Molecular Neurodegeneration