Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Jean K. Ho, Frank Moriarty, Jennifer J. Manly, Eric B. Larson, Denis A. Evans, Kumar B. Rajan, Elizabeth M. Hudak, Lamiaa Hassan, Enwu Liu, Nobuyuki Sato, Naoyuki Hasebe, Danielle Laurin, Pierre-Hugues Carmichael, Daniel A. Nation
Summary: Studies suggest that blood-brain barrier crossing renin-angiotensin drugs may be linked to less memory decline, while nonpenetrant medications may help improve attention.
Article
Health Care Sciences & Services
Hui Yin Lim, Sheila K. Patel, Ping Huang, Mark Tacey, Kay Weng Choy, Julie Wang, Geoffrey Donnan, Harshal H. Nandurkar, Prahlad Ho, Louise M. Burrell
Summary: The study found that plasma ACE2 activity is very low or undetectable in young healthy individuals and has minimal clinically relevant associations with coagulation function. However, patients with cardiovascular risk factors and/or disease have increased plasma ACE2 activity, suggesting that it may be an important biomarker for endothelial dysfunction and atherosclerosis.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Physiology
Haru Nomura, Sanjaya Kuruppu, Niwanthi W. Rajapakse
Summary: Diabetic nephropathy is a common disease leading to end-stage renal disease. Chronic activation of the RAAS contributes to kidney inflammation and fibrosis, resulting in kidney disease. Targeting the reno-protective arm of the RAAS provides potential therapeutic options for improving kidney inflammation and fibrosis in diabetic nephropathy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaofang Zeng, Anandharajan Rathinasabapathy, Dongliang Liu, Lihuang Zha, Xiangwei Liu, Yiyang Tang, Famei Li, Wenchao Lin, Zaixin Yu, Huiling Chen
Summary: The study found that hypertensive patients with COVID-19 are more likely to experience cardiac injury and severe disease phenotypes, including longer hospitalization time, higher rates of bilateral pneumonia, and electrolyte disorders. Cardiac injury markers such as creatine kinase and lactate dehydrogenase were also significantly increased in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Brasilina Caroccia, Paul-Emmanuel Vanderriele, Teresa Maria Seccia, Maria Piazza, Livia Lenzini, Selene Prisco, Francesca Torresan, Oliver Domenig, Maurizio Iacobone, Marko Poglitsch, Gian Paolo Rossi
Summary: This study found that ACE-2 mRNA and Ang II were present in human adrenocortical tissues, but not Ang-(1-7) and Ang-(1-5). Ang-(1-7) and ACE-2 do not seem to play a significant role in regulating aldosterone and cortisol biosynthesis.
JOURNAL OF HYPERTENSION
(2021)
Article
Cell Biology
Jorge F. Giani, Luciana C. Veiras, Justin Z. Y. Shen, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, Romer A. Gonzalez-Villalobos, Kenneth E. Bernstein
Summary: Renal angiotensin-converting enzyme (ACE) plays a key role in the development of various kidney diseases, particularly hypertension. Studies suggest that ACE may mediate its effects through mechanisms independent of Ang II conversion, involving other substrates.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Neurosciences
Priya Tiwari, Virendra Tiwari, Shivangi Gupta, Shubha Shukla, Kashif Hanif
Summary: This study reveals the important role of ACE2/Ang (1-7)/MasR axis in neuroinflammation. It decreases glial activation, neuroinflammation, and cell apoptosis, while improving mitochondrial health, thus providing neuroprotection.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Virology
Annika Lundstrom, Louise Ziegler, Sebastian Havervall, Ann-Sofie Rudberg, Fien von Meijenfeldt, Ton Lisman, Nigel Mackman, Per Sanden, Charlotte Thalin
Summary: The study found that levels of sACE2 were higher in COVID-19 patients compared to healthy controls, but decreased over time while remaining higher than in controls. The correlations of sACE2 and sACE levels with markers of inflammation and endothelial dysfunction were different, suggesting release from different cell types and/or vascular beds.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Arshad Mehmood, Fei Pan, Xin Ai, Xiaoning Tang, Shengbao Cai, Mohamed Mohamed Soliman, Sarah Albogami, Muhammad Usman, Mian Anjum Murtaza, Yanli Nie, Lei Zhao
Summary: This study identified novel ACE inhibitory peptides from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) through in silico digestion and in vitro assay, and analyzed their binding mechanisms with ACE. The results provide theoretical guidance for the development of novel foodborne antihypertensive peptides from Macadamia nut proteins.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Peripheral Vascular Disease
Ana R. Gaspar, Beatriz Andrade, Sara Mosca, Mariana Ferreira-Duarte, Ana Teixeira, Dina Cosme, Antonio Albino-Teixeira, Fernanda A. Ronchi, Ana P. Leite, Dulce E. Casarini, Jose C. Areias, Teresa Sousa, Alberto C. Afonso, Manuela Morato, Liane Correia-Costa
Summary: This study found that childhood obesity is associated with increased activities of angiotensin-converting enzymes (ACE) and ACE2. Overweight/obese children had significantly higher ACE and ACE2 activities compared to normal weight children. In girls, ACE and ACE2 activities were associated with increased night-time systolic and diastolic blood pressure.
JOURNAL OF HYPERTENSION
(2023)
Article
Cell Biology
Babak Saravi, Zhen Li, Valentina Basoli, Sibylle Grad, Sonja Haeckel, Christoph E. Albers, Mauro Alini, Hagen Schmal, Peter Obid, Gernot Lang
Summary: This study found that tissue renin-angiotensin system (tRAS) components are expressed in human nucleus pulposus (NP) cells and are associated with inflammatory and degenerative processes. These findings indicate that modulation of tRAS may be a novel therapeutic approach to intervertebral disc disease.
Review
Endocrinology & Metabolism
Yue Hu, Lihuan Liu, Xifeng Lu
Summary: ACE2, a negative regulator of the renin-angiotensin system, is the receptor for SARS-CoV-2 and plays a crucial role in the pathophysiology of COVID-19. It is implicated in tissue injury, chronic conditions such as hypertension, diabetes, and cardiovascular disease, and may be a potential therapeutic target for COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
Snigdha Mukerjee, Eric Lazartigues
NEUROSCIENCE BULLETIN
(2019)
Article
Peripheral Vascular Disease
Jiaxi Xu, Adrien J. R. Molinas, Snigdha Mukerjee, Donald A. Morgan, Kamal Rahmouni, Andrea Zsombok, Eric Lazartigues
Article
Peripheral Vascular Disease
Snigdha Mukerjee, Hong Gao, Jiaxi Xu, Ryosuke Sato, Andrea Zsombok, Eric Lazartigues
Article
Immunology
Chhinder P. Sodhi, Jenny Nguyen, Yukihiro Yamaguchi, Adam D. Werts, Peng Lu, Mitchell R. Ladd, William B. Fulton, Mark L. Kovler, Sanxia Wang, Thomas Prindle, Yong Zhang, Eric D. Lazartigues, Michael J. Holtzman, John F. Alcorn, David J. Hackam, Hongpeng Jia
JOURNAL OF IMMUNOLOGY
(2019)
Editorial Material
Cardiac & Cardiovascular Systems
Catalin M. Filipeanu, Eric Lazartigues
CARDIOVASCULAR RESEARCH
(2020)
Article
Peripheral Vascular Disease
Joshua M. Oakes, Jiaxi Xu, Tamara M. Morris, Nicholas D. Fried, Charlotte S. Pearson, Thomas D. Lobell, Nicholas W. Gilpin, Eric Lazartigues, Jason D. Gardner, Xinping Yue
Article
Cell Biology
Jiaxi Xu, Eric Lazartigues
Summary: The recent outbreak of COVID-19 caused by the novel coronavirus SARS-CoV-2 has spread rapidly worldwide. Similar to SARS-CoV, this new coronavirus utilizes ACE2 as an entry point to cells. Growing evidence suggests that COVID-19 patients, particularly those in severe condition, exhibit neurological symptoms, indicating the potential for SARS-CoV-2 to infect and damage neurons in the central nervous system. By studying human neurons derived from pluripotent stem cells, we have demonstrated the expression of ACE2 in human neurons. This highlights the importance of considering the neuro-invasive potential of SARS-CoV-2 as both a contributing factor and a therapeutic target for the severe respiratory symptoms in critical COVID-19 cases.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis
Review
Pharmacology & Pharmacy
Thyago M. de Queiroz, Navya Lakkappa, Eric Lazartigues
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Cell Biology
Blessing Ogunlade, Jessie J. Guidry, Snigdha Mukerjee, Srinivas Sriramula, Eric Lazartigues, Catalin M. Filipeanu
Summary: In this study, the researchers discovered that ACE2 is internalized and degraded in lysosomes after chronic Ang-II treatment. They identified fascin-1 as an accessory protein of ACE2 that interacts with the enzyme in an Ang-II dependent manner. Overexpression of fascin-1 attenuates the effects of Ang-II on ACE2 activity, while downregulation of fascin-1 severely decreases ACE2 enzymatic activity.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Mazher Mohammed, Clara Berdasco, Eric Lazartigues
Review
Multidisciplinary Sciences
Hongpeng Jia, Xinping Yue, Eric Lazartigues
NATURE COMMUNICATIONS
(2020)
Review
Medicine, Research & Experimental
Mona Elgazzaz, Eric Lazartigues
Summary: Cardiometabolic diseases are prevalent and high mortality diseases. The complexity of their etiology involves the intertwining of genetic and environmental factors through epigenetics, leading to diverse disease courses and outcomes among individuals. Targeting epigenetic imprints on genes like RAS can potentially impact the susceptibility to cardiometabolic dysfunction.
Article
Cardiac & Cardiovascular Systems
Juan Hong, Shubin Fu, Lie Gao, Yanhui Cai, Eric Lazartigues, Han-Jun Wang
Summary: The dysfunction of voltage-gated potassium (Kv) channels in dorsal root ganglions plays a critical role in mediating the exaggerated exercise pressor reflex and muscle afferent sensitization in chronic heart failure (CHF) patients. Manipulating Kv channels in DRG neurons could be a potential new approach to reduce sympathoexcitation and improve exercise intolerance in CHF, ultimately enhancing quality of life and reducing mortality.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Nicholas D. Fried, Anna Whitehead, Eric Lazartigues, Xinping Yue, Jason D. Gardner
Summary: This study using a bilateral ovariectomy model suggests that the cardiopulmonary protection observed in nicotine-exposed female mice may be independent of ovarian hormones.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)