Article
Medicine, Research & Experimental
Xilang Chen, Jie Chen, Weibo Feng, Wenjie Huang, Guodong Wang, Mengyu Sun, Xiangyuan Luo, Yijun Wang, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Summary: Elevated ELF4 expression is positively correlated with distant metastasis, advanced AJCC stages, and poor prognosis in colorectal cancer patients. ELF4 promotes CRC metastasis by transactivating its downstream target genes FGFR4 and SRC. FGF19 upregulates ELF4 expression through the ERK1/2/SP1 axis. Combination therapy with the FGFR4 inhibitor BLU-554 and the SRC inhibitor KX2-391 effectively suppresses ELF4-mediated CRC metastasis.
Article
Chemistry, Medicinal
Xiaolu Chen, Yanan Liu, Liting Zhang, Daoxing Chen, Zhaojun Dong, Chengguang Zhao, Zhiguo Liu, Qinqin Xia, Jianzhang Wu, Yongheng Chen, Xiaohui Zheng, Yuepiao Cai
Summary: In this study, a series of indazole derivatives were designed and synthesized, with F-30 showing subtle selectivity for FGFR4 and affecting cell growth and migration in HCC cell lines by inhibiting FGFR4 pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Youxi Yu, Xiaoju Shi, Qianqian Zheng, Xingtong Wang, Xingkai Liu, Min Tan, Guoyue Lv, Ping Zhang, Robert C. Martin, Yan Li
Summary: The study found that increased FGF15 in NASH-FGF21KO mice could not substitute for FGF21 to prevent NASH development. Up-regulated FGFR4 signaling in NASH-FGF21KO mice was associated with proliferation and epithelial-mesenchymal transition events, which are commonly linked to carcinogenic transformation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Shuxia Tian, Min Chen, Bing Wang, Yonglong Han, Haonan Shang, Junming Chen
Summary: This study identified that salvianolic acid B derived from Salvia miltiorrhiza can inhibit the proliferation and activation of hepatic stellate cells (HSCs) by regulating the FGF19/FGFR4 signaling pathway, demonstrating its anti-fibrotic effects in liver fibrosis.
ANNALS OF HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tianli Chen, Hongda Liu, Zengli Liu, Kangshuai Li, Ruixi Qin, Yue Wang, Jialiang Liu, Zhipeng Li, Qinglun Gao, Chang Pan, Fan Yang, Wei Zhao, Zongli Zhang, Yunfei Xu
Summary: The study revealed that FGF19 and FGFR4 are adverse prognostic biomarkers for gallbladder carcinoma, with their co-expression being a more sensitive predictor. FGF19 can promote GBC progression by stimulating FGFR4 activation via an autocrine pathway with bile as a potential carrier.
Article
Biochemistry & Molecular Biology
Aurelien Justet, Mada Ghanem, Tiara Boghanim, Mouna Hachem, Eirini Vasarmidi, Madeleine Jaillet, Aurelie Vadel, Audrey Joannes, Pierre Mordant, Philippe Bonniaud, Martin Kolb, Lei Ling, Aurelie Cazes, Herve Mal, Arnaud Mailleux, Bruno Crestani
Summary: This study identifies FGF19 as an antifibrotic molecule with potential therapeutic interest in fibrotic lung disorders. In vivo and in vitro experiments demonstrate that FGF19 can decrease lung fibrosis and fibrotic markers, modulate apoptosis of lung epithelial cells, and prevent myofibroblast differentiation.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Leilei Wang, Yuxiong Su, Wing Shan Choi
Summary: The study showed that melatonin suppresses invasion and migration of OSCC cells by blocking the FGF19/FGFR4 pathway, suggesting a potential alternative for OSCCs prevention and management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroshi Kishimoto, Toshiaki Nakano, Kumiko Torisu, Masanori Tokumoto, Yushi Uchida, Shunsuke Yamada, Masatomo Taniguchi, Takanari Kitazono
Summary: This study found that Indoxyl Sulfate (IS) increases fibroblast growth factor 23 (FGF23) protein expression through upregulation of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) and hypoxia-inducible factor 1 alpha expression. Meanwhile, IS activates the FGF23-FGFR4 signaling pathway in cardiomyocytes, leading to left ventricular hypertrophy (LVH).
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medical Laboratory Technology
Xing Li, Tinghong Zhou, Zexiang Zhu, Bo Xu
Summary: High serum concentrations of FGF19 at ICU admission were associated with an increased risk of 28-day mortality in sepsis patients. FGF19 together with Delta SOFA had a significantly better predictive value for mortality compared to Delta SOFA alone.
CLINICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Lan Ma, Chengmei Zhang, Yu Gui, Tingling Zou, Shuhua Xi, Xiaoying Guo
Summary: Excess intake of fluoride leads to fluorosis, which causes muscle damage. In this study, C2C12 cells were used to investigate the impact of fluoride on muscle development and the role of FGF21/ERK signaling pathway. Fluoride inhibited myogenic development and increased muscle atrophy-related markers. Pre-treatment with FGF21 reversed these effects and alleviated muscle atrophy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Yi-kuan Wu, Zheng-nan Ren, Sheng-long Zhu, Yun-zhou Wu, Gang Wang, Hao Zhang, Wei Chen, Zhao He, Xian-long Ye, Qi-xiao Zhai
Summary: Sulforaphane may ameliorate lipid metabolism disorders in NAFLD mice by upregulating the FGF21/FGFR1 pathway, making it a promising intervention to treat or relieve NAFLD.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Biochemistry & Molecular Biology
Yue Sui, Jianping Chen
Summary: Fibroblast growth factor 21 (FGF21) is a unique member of the FGF family with special endocrine properties. It has been extensively studied for its physiological functions in response to dietary manipulation, pharmacological benefits in improving macronutrient metabolism, and clinical values as a biomarker of various human diseases. This review focuses on the molecular biology of endocrine FGF21, particularly its regulation of circulating levels and emerging roles in inter-organ crosstalk and cancer development.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Guillaume Bourdon, Anthony Estienne, Claire Chevaleyre, Christelle Rame, Fabrice Guerif, Jean-Sebastien Brun, Claudine Vasseur, Gaelle Fromont, Ingrid Plotton, Diane Dufour-Rainfray, Erika Caldas-Silveira, Joelle Dupont, Pascal Froment, Pierre-Henri Ducluzeau
Summary: Lifestyle, environment, and excess body weight are associated with an increased risk of metabolic disorders and infertility. A hormone called fibroblast growth factor 21 (FGF21), mainly produced by the liver, is linked to the energy status and is increased in obesity and insulin resistance. While FGF21 has been linked to female fertility disorders, its role in male fertility is not well understood. This study found lower levels of FGF21 in seminal fluid compared to blood, and in vitro experiments demonstrated that FGF21 can improve sperm motility, ATP levels, and oxidative stress in spermatozoa.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Yun Jeong Lee, So Yoon Jung, Young Ah Lee, Jaehyun Kim, Seong Yong Lee, Choong Ho Shin
Summary: This study explored the relationship between fibroblast growth factor 21 (FGF21) levels and growth in children with growth hormone deficiency (GHD) and idiopathic short stature (ISS), as well as the impact of FGF21 levels on response to growth hormone (GH) treatment. The results showed that FGF21 levels were higher in short children, regardless of whether they had GHD or ISS, compared to children with normal growth. The pretreatment FGF21 level negatively affected the growth velocity of GH-treated GHD children, suggesting the existence of a GH/FFA/FGF21 axis in children.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Christopher Yanucil, Dominik Kentrup, Xueyi Li, Alexander Grabner, Karla Schramm, Eliana C. Martinez, Jinliang Li, Isaac Campos, Brian Czaya, Kylie Heitman, David Westbrook, Adam R. Wende, Alexis Sloan, Johanna M. Roche, Alessia Fornoni, Michael S. Kapiloff, Christian Faul
Summary: FGF21 targets cardiac myocytes to induce concentric hypertrophy, which may be a novel mechanism for heart failure in type 2 diabetes patients. Short-term elevation of FGF21 can be cardio-protective, but prolonged elevation may have adverse effects.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Zhifeng Huang, Yi Tan, Junlian Gu, Yang Liu, Lintao Song, Jianlou Niu, Longwei Zhao, Lakshmi Srinivasan, Qian Lin, Jingjing Deng, Yang Li, Daniel J. Conklin, Thomas A. Neubert, Lu Cai, Xiaokun Li, Moosa Mohammadi
Article
Medicine, General & Internal
Jun Zhang, Jamila Gupte, Yan Gong, Jennifer Weiszmann, Yuan Zhang, Ki Jeong Lee, William G. Richards, Yang Li
Article
Biochemistry & Molecular Biology
Sally Yu Shi, Ya-Wen Lu, Zhi Liu, Jennitte Stevens, Christopher M. Murawsky, Vicki Wilson, Zhonghua Hu, William G. Richards, Mark Leo Michaels, Jun Zhang, Wei Yan, Yang Li
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Sally Yu Shi, Ya-Wen Lu, Jason Richardson, Xiaoshan Min, Jennifer Weiszmann, William G. Richards, Zhulun Wang, Zhongqi Zhang, Jun Zhang, Yang Li
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Xiaoshan Min, Jennifer Weiszmann, Sheree Johnstone, Wei Wang, Xinchao Yu, William Romanow, Stephen Thibault, Yang Li, Zhulun Wang
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
Warren N. D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Joseph R. Maxwell, James B. Rottman, Katja Labitzke, Angela Willee, Holger Beckmann, Yingcai Wang, Yang Li, Ralf Schwandner, James A. Johnston, Jennifer E. Towne, Hailing Hsu
Article
Multidisciplinary Sciences
Zhengjian Zhang, Caroline Broderick, Marni Nishimoto, Teppei Yamaguchi, Sung-Jin Lee, Haili Zhang, Hui Chen, Mehaben Patel, Jay Ye, Alberto Ponce, Jennifer Brady, Helene Baribault, Yang Li, Wen-Chen Yeh
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Tristan W. Fowler, Troy L. Mitchell, Claudia Y. Janda, Liqin Xie, Shengjiang Tu, Hui Chen, Haili Zhang, Jingjing Ye, Brian Ouyang, Tom Z. Yuan, Sung-Jin Lee, Maureen Newman, Nikita Tripuraneni, Erica S. Rego, Devin Mutha, Archana Dilip, Meghah Vuppalapaty, Helene Baribault, Wen-Chen Yeh, Yang Li
Summary: The study introduces a novel antibody-based platform for generating potent Wnt mimetics to address conditions like osteoporosis. The synthetic Wnt agonists demonstrate rapid bone building effects in murine models, indicating potential for therapeutic use in bone-related disorders.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Liqin Xie, Russell B. Fletcher, Diksha Bhatia, Darshini Shah, Jacqueline Phipps, Shalaka Deshmukh, Haili Zhang, Jingjing Ye, Sungjin Lee, Lucas Le, Maureen Newman, Hui Chen, Asmiti Sura, Suhani Gupta, Laura E. Sanman, Fan Yang, Weixu Meng, Helene Baribault, Geertrui F. Vanhove, Wen -Chen Yeh, Yang Li, Chenggang Lu
Summary: The study demonstrates that modulation of Wnt signaling is a potential approach to treating epithelial damage in inflammatory bowel disease. Exogenous R-spondin and Wnt mimetics can repair damaged intestinal epithelium, reduce disease activity and inflammation. Among them, the Wnt mimetic SZN-1326-p, specific to receptors FZD5/8 and LRP6, shows robust repair effects.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Ophthalmology
Huy Nguyen, Hui Chen, Meghah Vuppalapaty, Elizabeth Whisler, Kelsey Ronarda Logas, Parthasarathy Sampathkumar, Russell Byron Fletcher, Asmiti Sura, Nicholas Suen, Suhani Gupta, Tom Lopez, Jay Ye, Shengjiang Tu, Menaka Bolaki, Wen-Chen Yeh, Yang Li, Sung-Jin Lee
Summary: This study developed a Norrin mimetic targeting FZD4 and LRP5, named SZN-413-p, and demonstrated its ability to promote the regeneration of functional blood vessels in animal models. After humanization, SZN-413 showed significant efficacy in reducing neovascularization and avascular areas in a mouse model. Moreover, it effectively reduced retinal vascular leakage in a rabbit model. These findings suggest that SZN-413 can offer a new therapeutic strategy for diabetic retinopathy.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huy Nguyen, Sung-Jin Lee, Yang Li
Summary: Retinal ischemia is a major cause of visual impairment and blindness worldwide, often associated with various disorders. Diabetic retinopathy is a common cause, and its exact pathogenesis remains unclear, but vascular leakage plays a significant role in visual impairment. Current treatments have limitations, therefore there is a need for new therapies to address vessel regeneration and reperfusion in ischemic retinal areas. The Wnt signaling pathway in the retina could provide a novel disease modifying therapy.
Article
Multidisciplinary Sciences
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo
Summary: Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in various disorders. A non-lipidated, FZD(4)-specific surrogate called L6-F4-2 has been developed and shown to improve BBB and BRB function. It also demonstrates systemic efficacy during ischemic stroke BBB dysfunction.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Hui Chen, Chenggang Lu, Sung-Jin Lee, Yang Li
Article
Biochemistry & Molecular Biology
Hui Chen, Chenggang Lu, Brian Ouyang, Haili Zhang, Zhong Huang, Diksha Bhatia, Sung-Jin Lee, Darshini Shah, Asmiti Sura, Wen-Chen Yeh, Yang Li
CELL CHEMICAL BIOLOGY
(2020)
Article
Biology
Maia Azubel, Stephen D. Carter, Jennifer Weiszmann, Jun Zhang, Grant J. Jensen, Yang Li, Roger D. Kornberg
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)