A systematic dissection of sequence elements determining β-Klotho and FGF interaction and signaling

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

(2018) Archita Agrawal et al.   Molecular Metabolism

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

(2018) Gaozhi Chen et al.   NATURE

Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling

(2018) Sangwon Lee et al.   NATURE

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

(2017) Shanaka Stanislaus et al.   ENDOCRINOLOGY

Effect of Fc-Glycan Structure on the Conformational Stability of IgG Revealed by Hydrogen/Deuterium Exchange and Limited Proteolysis

(2016) Jing Fang et al.   BIOCHEMISTRY

A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects

(2016) Saswata Talukdar et al.   Cell Metabolism

Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth Factor 21

(2016) Diana Ronai Dunshee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast activation protein (FAP) as a novel metabolic target

(2016) Miguel Angel Sánchez-Garrido et al.   Molecular Metabolism

Circulating FGF21 proteolytic processing mediated by fibroblast activation protein

(2015) E. Y. Zhen et al.   BIOCHEMICAL JOURNAL

Conformational Difference in Human IgG2 Disulfide Isoforms Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

(2015) Aming Zhang et al.   BIOCHEMISTRY

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

(2015) Ganesh Kolumam et al.   EBioMedicine

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LY2405319, an Engineered FGF21 Variant, Improves the Metabolic Status of Diabetic Monkeys

(2013) Andrew C. Adams et al.   PLoS One

FGF21 Can Be Mimicked In Vitro and In Vivo by a Novel Anti-FGFR1c/β-Klotho Bispecific Protein

(2013) Richard Smith et al.   PLoS One

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

(2012) Andrew J. Percy et al.   ANALYTICA CHIMICA ACTA

Improved Protein Hydrogen/Deuterium Exchange Mass Spectrometry Platform with Fully Automated Data Processing

(2012) Zhongqi Zhang et al.   ANALYTICAL CHEMISTRY

Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis

(2012) Janelle Stoops et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Long-Acting FGF21 Has Enhanced Efficacy in Diet-Induced Obese Mice and in Obese Rhesus Monkeys

(2012) Murielle M. Véniant et al.   ENDOCRINOLOGY

Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands

(2012) R. Goetz et al.   MOLECULAR AND CELLULAR BIOLOGY

FGF21 Requires βklotho to Act In Vivo

(2012) Andrew C. Adams et al.   PLoS One

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

(2012) Randy Hecht et al.   PLoS One

Treating Diabetes and Obesity with an FGF21-Mimetic Antibody Activating the  Klotho/FGFR1c Receptor Complex

(2012) I. N. Foltz et al.   Science Translational Medicine

FGF21 Analogs of Sustained Action Enabled by Orthogonal Biosynthesis Demonstrate Enhanced Antidiabetic Pharmacology in Rodents

(2011) J. Mu et al.   DIABETES

Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease

(2011) N. Itoh et al.   JOURNAL OF BIOCHEMISTRY

In VivoCrystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells

(2011) Haruki Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The FGFR D3 Domain Determines Receptor Selectivity For Fibroblast Growth Factor 21

(2011) Jamila Gupte et al.   JOURNAL OF MOLECULAR BIOLOGY

Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19)

(2010) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Determination of amide hydrogen exchange by mass spectrometry: A new tool for protein structure elucidation

(2010) Zhongqi Zhang et al.   PROTEIN SCIENCE

Different roles of N- and C- termini in the functional activity of FGF21

(2009) Radmila Micanovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

FGF21 N- and C-termini play different roles in receptor interaction and activation

(2008) Junming Yie et al.   FEBS LETTERS

C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors

(2008) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY