Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity

Antioxidant defense and aging inC. elegans: Is the oxidative damage theory of aging wrong?

(2011) David Gems et al.   CELL CYCLE

Fibroblasts From Naked Mole-Rats Are Resistant to Multiple Forms of Cell Injury, But Sensitive to Peroxide, Ultraviolet Light, and Endoplasmic Reticulum Stress

(2011) A. B. Salmon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels

(2010) Nicole F. Villeneuve et al.   CELL CYCLE

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

(2010) Jonathan Maher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State

(2009) Mustafa Zakkar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

When a theory of aging ages badly

(2009) Jérôme Lapointe et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Responses of glutamate cysteine ligase and glutathione to oxidants in deer mice (Peromyscus maniculatus)

(2009) Hongmei Wu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis

(2009) Adam B. Salmon et al.   FASEB JOURNAL

Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span

(2009) Adam B. Salmon et al.   FASEB JOURNAL

Activation of antioxidant defense during dehydration stress in the African clawed frog

(2009) Amal Idris Malik et al.   GENE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice

(2009) Weisong Duan et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response

(2009) Weimin Chen et al.   MOLECULAR CELL

Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial KATP channels

(2009) Cheng Shi Piao et al.   PHARMACOLOGICAL RESEARCH

Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat

(2009) V. I. Perez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

(2009) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Increased Susceptibility of Nrf2 Knockout Mice to Colitis-Associated Colorectal Cancer

(2008) T. O. Khor et al.   Cancer Prevention Research

Combined action and regulation of phase II enzymes and multidrug resistance proteins in multidrug resistance in cancer

(2008) Irma Meijerman et al.   CANCER TREATMENT REVIEWS

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

(2008) X.-J. Wang et al.   CARCINOGENESIS

SKNy Worms and Long Life

(2008) Heinrich Jasper   CELL

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

(2008) Jennifer M.A. Tullet et al.   CELL

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease

(2008) Yifeng Du et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Nrf3 Transcription Factor Is a Membrane-bound Glycoprotein Targeted to the Endoplasmic Reticulum through Its N-terminal Homology Box 1 Sequence

(2008) Yiguo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species

(2008) Rochelle Buffenstein   JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMIC AND ENVIRONMENTAL PHYSIOLOGY

Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus

(2008) Pier Jr Morin et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A systematic look at an old problem

(2008) Thomas B. L. Kirkwood   NATURE

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

(2008) K. J. Pearson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

(2007) C. Cavin et al.   FOOD AND CHEMICAL TOXICOLOGY

Small Maf Proteins in Mammalian Gene Control: Mere Dimerization Partners or Dynamic Transcriptional Regulators?

(2007) Volker Blank   JOURNAL OF MOLECULAR BIOLOGY

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH