☆ 4.6 Article

Ruthenium-catalyzed cyclization of N-carbamoyl indolines with alkynes: an efficient route to pyrroloquinolinones

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

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ORGANIC & BIOMOLECULAR CHEMISTRY

卷 13, 期 35, 页码 9276-9284

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ROYAL SOC CHEMISTRY

DOI: 10.1039/c5ob01146a

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Chemistry, Organic

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CSIR, India [02(0179)/14/EMR-II]

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A regioselective synthesis of substituted pyrroloquinolinones via a ruthenium-catalyzed oxidative cyclization of substituted N-carbamoyl indolines with alkynes is described. The cyclization reaction was compatible with various symmetrical and unsymmetrical alkynes including substituted propiolates. Later, we performed the aromatization of pyrroloquinolinones into indole derivatives in the presence of 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ).

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