Article
Microbiology
Jing Xu, Jie Gao, Maolin Zhang, Danwei Zhang, Ming Duan, Zhenhong Guan, Yidi Guo
Summary: Rabies virus infects N2a cells in a manner dependent on microtubule integrity as well as the function of dynein and kinesin. Microtubule-depolymerizing drugs, dynein inhibitors, and disruption of kinesin function can all hinder Rabies virus infection.
VETERINARY MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Alexander S. Zhovmer, Alexis Manning, Chynna Smith, James B. Hayes, Dylan T. Burnette, Jian Wang, Alexander X. Cartagena-Rivera, Nikolay V. Dokholyan, Rakesh K. Singh, Erdem D. Tabdanov
Summary: The study demonstrates an antagonistic mechanical balance within the dynein-kinesin microtubular motor system, where dynein activity drives inward compaction of the microtubular network, while kinesins bundle and expand MTs into giant circular bands. This balance controls the 3D architecture, mechanics, and cell-microenvironment interactions of cells through orthogonal mechanisms of MT network reorganization.
Review
Cell Biology
Wouter Mul, Aniruddha Mitra, Erwin J. G. Peterman
Summary: In this review, the authors explore the regulation of intraflagellar transport (IFT) in cilia from three different perspectives: the motor track, motor proteins, and kinases. By discussing these factors, the authors provide mechanistic insights into IFT regulation in cilia and suggest directions for future research.
Review
Cell Biology
Thomas D. D. Cushion, Ines Leca, David A. A. Keays
Summary: Microtubules are essential for various cellular functions and mutations in tubulin genes can lead to a range of diseases collectively known as tubulinopathies. Recent studies have shown that these mutations also affect microtubule-associated proteins (MAPs), which play important roles in microtubule regulation. In this review, we analyze the disease mechanisms caused by tubulin mutations on MAP binding and discuss how genetic variation can be utilized to identify novel MAPs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Himanshu Pandey, Mary Popov, Alina Goldstein-Levitin, Larisa Gheber
Summary: Kinesin-5 motor proteins play crucial roles in cell division with their specialized structural features and diverse functions. Research has shown their different mechanisms of action in dividing and non-dividing cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Antonina J. Kruppa, Folma Buss
Summary: Mitochondria are essential organelles in cells, playing roles in energy production, cell signalling, apoptosis, and biosynthesis. Motor proteins and their associated tracks are crucial for maintaining mitochondrial homeostasis, regulating processes such as transport and docking of mitochondria.
JOURNAL OF CELL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Pedro Monteiro, Bongwhan Yeon, Samuel S. Wallis, Susana A. Godinho
Summary: Intracellular organelle organization in eukaryotic cells is achieved by active transport along microtubules. Centrosome amplification, commonly observed in cancer, induces a change in organelle positioning that facilitates nuclear migration. Increased tubulin acetylation differentially regulates kinesin-1-mediated organelle displacement to regulate intracellular organization.
Review
Cell Biology
Yi-Yang Pan, Ying Deng, Shuai Su, Jiu-Heng Yin, Yi-Hui Chen, Liu-Can Wang, Li-Hua Sun, Wei-Dong Xiao, Guang-Sheng Du
Summary: Tight junctions play a crucial role in maintaining the integrity and permeability of the intestinal epithelial barrier. Disruption of tight junction formation or integrity can lead to various gastrointestinal diseases. The mechanism of intracellular transport of tight junction proteins remains unclear and requires further study.
Review
Cell Biology
Wen Lu, Vladimir I. Gelfand
Summary: Cells are the smallest building blocks of living organisms, and often undergo cytoplasmic streaming to compensate for physical constraints in large cells. This phenomenon is driven by molecular motors and plays important roles in various cell types. Additionally, intercellular flow transports cytoplasmic materials for rapid oocyte growth.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biology
Chuying Zhou, Mineko Kengaku
Summary: Neuronal migration is a crucial process in brain development. Nesprin-2, a nuclear membrane protein, acts as an adapter to facilitate the movement of neuronal nucleus along microtubule tracks. Recent evidence suggests that Nesprin-2 plays a pivotal role in mediating bidirectional neuronal nuclear movements.
Review
Virology
Duncan W. Wilson
Summary: Alphaherpesviruses infect the mammalian nervous system through mucosal epithelia, establish latency in the peripheral nervous system, and rely on microtubule- and actin-dependent cellular motors for efficient transport of viral particles during assembly and egress.
Article
Biochemistry & Molecular Biology
Xin Zhu, Jieling Wang, Shufen Li, Karl Lechtreck, Junmin Pan
Summary: This study revealed that the IFT-B protein IFT54 interacts with both kinesin-II and IFT dynein, regulating anterograde transport. Deletions of specific residues in IFT54 resulted in disrupted anterograde trafficking of IFT, with accumulations of IFT motors and complexes in different regions of cilia. This suggests a central role for IFT54 in binding IFT motors during anterograde transport.
Article
Multidisciplinary Sciences
Sithara S. Wijeratne, Shane A. Fiorenza, Alex E. Neary, Radhika Subramanian, Meredith D. Betterton
Summary: This study reports that microtubules can physically couple motor movement in the absence of detectable short-range interactions. The long-range microtubule-mediated coupling mechanism may affect the binding kinetics and mechanochemistry of motors, providing new forms of collective motor behavior.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Diksha Kumari, Krishanu Ray
Summary: Phosphorylation of Kinesin subunits and adaptors plays a crucial role in regulating the activity and interactions of Kinesin motors, influencing intracellular transport dynamics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiangyu Fan, Richard J. McKenney
Summary: This study reveals the crucial role of a specialized kinesin tail domain in directing motor transport along specific microtubule tracks. The tail domain affects the initial motor-microtubule interaction and the processive motility, and its effect is enhanced when the motor domain is in the ADP state.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sungjin Park, Peter K. Foote, David T. Krist, Sarah E. Rice, Alexander V. Statsyuk
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Amelie Robert, Peirun Tian, Stephen A. Adam, Mark Kittisopikul, Khuloud Jaqaman, Robert D. Goldman, Vladimir I. Gelfand
Article
Biophysics
Dietmar B. Oelz, Urko del Castillo, Vladimir Gelfand, Alex Mogilner
BIOPHYSICAL JOURNAL
(2018)
Article
Cell Biology
Wen Lu, Margot Lakonishok, Anna S. Serpinskaya, David Kirchenbuechler, Shuo-Chien Ling, Vladimir I. Gelfand
JOURNAL OF CELL BIOLOGY
(2018)
Editorial Material
Cell Biology
Rosalind Norkett, Wen Lu, Vladimir I. Gelfand
DEVELOPMENTAL CELL
(2019)
Review
Cell Biology
Urko del Castillo, Rosalind Norkett, Vladimir I. Gelfand
TRENDS IN CELL BIOLOGY
(2019)
Article
Biology
Rosalind Norkett, Urko del Castillo, Wen Lu, Vladimir Gelfand
Article
Biology
Wen Lu, Margot Lakonishok, Rong Liu, Neil Billington, Ashley Rich, Michael Glotzer, James R. Sellers, Vladimir Gelfand
Article
Biology
Wen Lu, Margot Lakonishok, Anna S. Serpinskaya, Vladimir Gelfand
Summary: Cytoplasmic dynein plays essential roles in Drosophila oocyte growth by actively moving microtubules within nurse cells and from nurse cells to the oocyte via the cytoplasmic bridges, and this movement can transport cytoplasmic particles to the oocyte.
Review
Cell Biology
Wen Lu, Vladimir I. Gelfand
Summary: Cells are the smallest building blocks of living organisms, and often undergo cytoplasmic streaming to compensate for physical constraints in large cells. This phenomenon is driven by molecular motors and plays important roles in various cell types. Additionally, intercellular flow transports cytoplasmic materials for rapid oocyte growth.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Bhuvanasundar Renganathan, James P. Zewe, Yuan Cheng, Jean-Michel Paumier, Mark Kittisopikul, Karen M. Ridge, Puneet Opal, Vladimir I. Gelfand
Summary: Gigaxonin acts as an adaptor protein for E3 ubiquitin ligase and is essential for ubiquitination and degradation of intermediate filament (IF) proteins. Mutations in the GAN gene, which encodes gigaxonin, cause giant axonal neuropathy characterized by abnormal accumulation of IFs. This study shows that loss of gigaxonin inhibits IF transport along microtubules by the motor protein kinesin-1, leading to abnormal IF distribution.
Article
Multidisciplinary Sciences
Urko del Castillo, Hans-Arno J. Mueller, Vladimir I. Gelfand
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Maria Cecilia De Rossi, Diana E. Wetzler, Lorena Bensenor, Maria Emilia De Rossi, Mariela Sued, Daniela Rodriguez, Vladimir Gelfand, Luciana Bruno, Valeria Levi
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2017)
Article
Cell Biology
Kathleen G. Bickel, Barbara J. Mann, Joshua S. Waitzman, Taylor A. Poor, Sarah E. Rice, Patricia Wadsworth
Meeting Abstract
Biophysics
Kyle P. Smith, Pamela J. Focia, Yongbo Zhang, Julian L. Klosowiak, Douglas M. Freymann, Sarah E. Rice
BIOPHYSICAL JOURNAL
(2017)