KrasG12D induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

(2015) Sapna Puri et al.   Cell Stem Cell

Lineage fate of ductular reactions in liver injury and carcinogenesis

(2015) Simone Jörs et al.   JOURNAL OF CLINICAL INVESTIGATION

Detection of Tumor Suppressor Genes in Cancer Development by a Novel shRNA-Based Method

(2015) J. von Burstin et al.   MOLECULAR CANCER RESEARCH

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma

(2015) Pawel K Mazur et al.   NATURE MEDICINE

Disclosure of Erlotinib as a Multikinase Inhibitor in Pancreatic Ductal Adenocarcinoma

(2015) Laura Conradt et al.   NEOPLASIA

Oncogenic KRAS signalling in pancreatic cancer

(2014) S Eser et al.   BRITISH JOURNAL OF CANCER

Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells

(2014) Rocio Sancho et al.   Cell Stem Cell

A modular and flexible ESC-based mouse model of pancreatic cancer

(2014) M. Saborowski et al.   GENES & DEVELOPMENT

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

(2014) Nina Schönhuber et al.   NATURE MEDICINE

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

(2014) Matthias Wirth et al.   NUCLEIC ACIDS RESEARCH

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas

(2014) Irene Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma

(2014) W. Zhang et al.   Science Signaling

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer

(2013) W.-c. Lin et al.   CANCER RESEARCH

The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

(2013) M. Reichert et al.   GENES & DEVELOPMENT

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Direct reprogramming by oncogenic Ras and Myc

(2013) I. Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ready, Set, Go: The EGF Receptor at the Pancreatic Cancer Starting Line

(2012) Rushika M. Perera et al.   CANCER CELL

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Oncogenic Kras-Induced GM-CSF Production Promotes the Development of Pancreatic Neoplasia

(2012) Yuliya Pylayeva-Gupta et al.   CANCER CELL

EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma

(2012) Carolina Navas et al.   CANCER CELL

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

(2012) Christine M. Ardito et al.   CANCER CELL

KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling

(2012) V. A. Appleman et al.   MOLECULAR CANCER RESEARCH

p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells

(2011) Andreia V. Pinho et al.   CELL CYCLE

Reviewing once more the c-myc and Ras collaboration

(2011) Chenguang Wang et al.   CELL CYCLE

Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents

(2011) Paul J. Grippo et al.   INTERNATIONAL JOURNAL OF CANCER

Pancreatic ductal cells in development, regeneration, and neoplasia

(2011) Maximilian Reichert et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells

(2010) Kyoung Eun Lee et al.   CANCER CELL

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells

(2009) Carolin Schild et al.   MOLECULAR CARCINOGENESIS

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Conditional inactivation of Myc impairs development of the exocrine pancreas

(2008) H. Nakhai et al.   DEVELOPMENT

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

(2008) Claire Bonal et al.   GASTROENTEROLOGY

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE