Article
Biochemistry & Molecular Biology
Ting-You Wang, Qi Liu, Yanan Ren, Sk Kayum Alam, Li Wang, Zhu Zhu, Luke H. Hoeppner, Scott M. Dehm, Qi Cao, Rendong Yang
Summary: Exitron splicing (EIS) functions in cancer by affecting 63% of human coding genes, 95% of which are tumor specific. EIS alters cancer driver genes, leading to gain- or loss-of-function, and also produces neoepitopes that bind to MHC class I or II. Analysis of clinical data shows a correlation between EIS-derived neoantigen load and checkpoint inhibitor response in clear cell renal cell carcinoma.
Article
Medical Laboratory Technology
Sepideh Sadighbathi, Ahmad Mobed
Summary: MicroRNAs are small non-coding RNAs, with miR21 being highly expressed in many mammalian cells and regulating various biological functions. Accurate detection of miR-21 is crucial, and conventional methods have limitations. Advanced techniques such as nanotechnology and biosensors have gained attention in recent years.
CLINICA CHIMICA ACTA
(2022)
Article
Oncology
Yousef M. Hawsawi, Anwar Shams, Abdulrahman Theyab, Wed A. Abdali, Nahed A. Hussien, Hanan E. Alatwi, Othman R. Alzahrani, Atif Abdulwahab A. Oyouni, Ahmad O. Babalghith, Mousa Alreshidi
Summary: This article reviews the spectrum of full-length BARD1 genes and their different isoforms, highlighting their anticipated associated risk. Additionally, the study emphasizes the role of BARD1 as an oncogene in breast cancer patients and its potential uses as a prognostic/diagnostic biomarker and therapeutic target for cancer susceptibility testing and treatment.
Article
Multidisciplinary Sciences
Malvika Sudhakar, Raghunathan Rengaswamy, Karthik Raman
Summary: This study defines new features and builds a pan-cancer model, cTaG, to identify new driver genes. It overcomes bias towards genes with low mutation rates and low recall, and predicts potential new driver genes.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Article
Oncology
Heng Pan, Loic Renaud, Ronan Chaligne, Johannes Bloehdorn, Eugen Tausch, Daniel Mertens, Anna Maria Fink, Kirsten Fischer, Chao Zhang, Doron Betel, Andreas Gnirkell, Marcin Imielinski, Jerome Moreaux, Michael Hallek, Alexander Meissner, Stephan Stilgenbauer, Catherine J. Wu, Olivier Elemento, Dan A. Landau
Summary: MethSig is a novel statistical framework for analyzing DNA methylation changes in cancer, specifically identifying candidate DNA methylation driver genes of cancer progression and relapse, empowering the discovery of epigenetic mechanisms that enhance cancer cell fitness.
Article
Biochemical Research Methods
Chen Hong, Robin Thiele, Lars Feuerbach
Summary: Analyzing focal copy number variations (CNVs) is crucial for cancer research as it helps identify driver genes. We have developed the GenomeTornadoPlot software package that provides visualizations of CNV types, locations, and lengths, and allows for gene-to-gene comparisons to identify co-mutation patterns or driver-passenger gene hierarchies.
Review
Chemistry, Medicinal
Asiyeh Jebelli, Behzad Baradaran, Jafar Mosafer, Amir Baghbanzadeh, Ahad Mokhtarzadeh, Lobat Tayebi
Summary: Colorectal cancer is a challenging and heterogeneous cancer that cannot be effectively overcome by common conventional therapies. Research indicates that RNA interference could be an important avenue to generate great therapeutic efficacy for CRC. Targeting CRC tumor-related genes with small interfering RNAs and short hairpin RNAs can bring benefits, and the synergistic effects of RNAi with inhibitors/chemotherapy agents can increase the sensitivity of CRC cells to common therapies.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Chemistry, Inorganic & Nuclear
Ziyu Li, Jiaqi Zhang, Yixuan Huang, Jinxia Zhai, Guangfu Liao, Zhengao Wang, Chengyun Ning
Summary: The sensitivity and stability of immunosensor for early-stage cancer diagnosis can be improved through the development of electroactive biomaterials. This review provides a systematic summary of the principle and recent advances in mainstream immunosensor based on electroactive materials, highlighting the fabrication, architecture, and signal-amplified mechanism of electroactive materials, as well as their application in cancer biomarker detection. The review also discusses the challenges and future development of immunosensor in clinical applications.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Sepideh Chodary Khameneh, Sara Razi, Sara Shamdani, Georges Uzan, Sina Naserian
Summary: This study analyzed microarray gene expression data to identify differentially expressed lncRNAs and hub genes associated with colorectal cancer (CRC). The findings contribute to a better understanding of CRC and suggest potential prognostic/diagnostic biomarkers.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Huanhuan Chen, Keqing Yang, Lingxiao Pang, Jing Fei, Yongliang Zhu, Jianwei Zhou
Summary: This study identified a novel protein, ANKRD22, involved in regulating the immunosuppressive ability of PMN-MDSCs. It was found that ANKRD22 levels were associated with the clinical characteristics and prognosis of ovarian cancer patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Alinne T. F. Silva, Claudia M. Rodrigues, Izabella C. C. Ferreira, Leticia L. D. Santos, Donizeti W. Santos, Thaise G. Araujo, Paula P. L. Canto, Carlos E. Paiva, Luiz R. Goulart, Yara C. P. Maia
Summary: In this study, we analyzed the presence of circulating tumor cells (CTCs) in the blood to identify markers for the diagnosis and monitoring of breast cancer. By determining the transcriptional levels and flow cytometry profiles, we developed a method that shows high sensitivity and specificity for breast cancer detection and therapy monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Oncology
Sadegh Rajabi, Catherine Alix-Panabieres, Arshia Sharbatdar Alaei, Raziyeh Abooshahab, Heewa Shakib, Mohammad Reza Ashrafi
Summary: This review discusses the inactivation mechanisms and alterations of tumor-suppressor genes in thyroid cancer in order to identify more effective treatment options.
Article
Biochemistry & Molecular Biology
Seong Beom Cho
Summary: This research used multi-omics data analysis to investigate the molecular mechanisms of tumor suppressor genes in breast cancer. The results showed that tumor suppressor genes are significantly related to gene ontology terms related to cell cycle, genome stability, RNA processing, and metastasis, revealing the regulatory mechanisms of tumor suppressor genes on cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)