Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
出版年份 2014 全文链接
标题
Downstream of Mutant KRAS, the Transcription Regulator YAP Is Essential for Neoplastic Progression to Pancreatic Ductal Adenocarcinoma
作者
关键词
-
出版物
Science Signaling
Volume 7, Issue 324, Pages ra42-ra42
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2014-05-07
DOI
10.1126/scisignal.2005049
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Progressive Metaplastic and Dysplastic Changes in Mouse Pancreas Induced by Cyclooxygenase-2 Overexpression
- (2015) Jennifer K.L. Colby et al. NEOPLASIA
- Interleukin 1α Sustains the Expression of Inflammatory Factors in Human Pancreatic Cancer Microenvironment by Targeting Cancer-Associated Fibroblasts
- (2015) Vegard Tjomsland et al. NEOPLASIA
- A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer
- (2014) Shi Jiao et al. CANCER CELL
- Selective Requirement of PI3K/PDK1 Signaling for Kras Oncogene-Driven Pancreatic Cell Plasticity and Cancer
- (2013) Stefan Eser et al. CANCER CELL
- Molecular Pathways: YAP and TAZ Take Center Stage in Organ Growth and Tumorigenesis
- (2013) S. Piccolo et al. CLINICAL CANCER RESEARCH
- Control of the Hippo Pathway by Set7-Dependent Methylation of Yap
- (2013) Menno J. Oudhoff et al. DEVELOPMENTAL CELL
- Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins
- (2013) B.V.V.G. Reddy et al. DEVELOPMENTAL CELL
- Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
- (2013) Tao Gao et al. GASTROENTEROLOGY
- Clinical Significance of Yes-Associated Protein Overexpression in Cervical Carcinoma
- (2013) Tianbo Liu et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation
- (2013) Lisa D. Mills et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting Mutant KRAS for Anticancer Therapeutics: A Review of Novel Small Molecule Modulators
- (2013) Yuanxiang Wang et al. JOURNAL OF MEDICINAL CHEMISTRY
- TRIB2 Acts Downstream of Wnt/TCF in Liver Cancer Cells to Regulate YAP and C/EBPα Function
- (2013) Jiayi Wang et al. MOLECULAR CELL
- US National Cancer Institute's new Ras project targets an old foe
- (2013) Helen Thompson NATURE MEDICINE
- Overexpression of YAP and TAZ Is an Independent Predictor of Prognosis in Colorectal Cancer and Related to the Proliferation and Metastasis of Colon Cancer Cells
- (2013) Lijuan Wang et al. PLoS One
- CTGF antagonism with mAb FG-3019 enhances chemotherapy response without increasing drug delivery in murine ductal pancreas cancer
- (2013) A. Neesse et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1
- (2013) R. Fan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis
- (2013) C. Yi et al. Science Signaling
- Regulation of the Hippo pathway and implications for anticancer drug development
- (2013) Hyun Woo Park et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Pancreatic cancer circulating tumour cells express a cell motility gene signature that predicts survival after surgery
- (2012) Gregory Sergeant et al. BMC CANCER
- Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
- (2012) Janel L. Kopp et al. CANCER CELL
- KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
- (2012) Jianhua Ling et al. CANCER CELL
- Disputed Paternity: The Uncertain Ancestry of Pancreatic Ductal Neoplasia
- (2012) Anirban Maitra et al. CANCER CELL
- EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
- (2012) Carolina Navas et al. CANCER CELL
- EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
- (2012) Christine M. Ardito et al. CANCER CELL
- Apricoxib, a Novel Inhibitor of COX-2, Markedly Improves Standard Therapy Response in Molecularly Defined Models of Pancreatic Cancer
- (2012) A. Kirane et al. CLINICAL CANCER RESEARCH
- The Pancreas Cancer Microenvironment
- (2012) C. Feig et al. CLINICAL CANCER RESEARCH
- The role of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in the development of esophageal cancer
- (2012) Magdalena Groblewska et al. FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
- What We Have Learned About Pancreatic Cancer From Mouse Models
- (2012) Pedro A. Pérez–Mancera et al. GASTROENTEROLOGY
- Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)
- (2012) J.-S. Mo et al. GENES & DEVELOPMENT
- Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
- (2012) Y. Liu-Chittenden et al. GENES & DEVELOPMENT
- The Matricellular Protein CCN1/Cyr61 Is a Critical Regulator of Sonic Hedgehog in Pancreatic Carcinogenesis
- (2012) Inamul Haque et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response toSN2 Alkylating Agents
- (2012) Shoji Hata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Identification of Mechanism That Couples Multisite Phosphorylation of Yes-associated Protein (YAP) with Transcriptional Coactivation and Regulation of Apoptosis
- (2012) Kyung-Kwon Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells
- (2012) Wesley M. Konsavage et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hippo Signaling Regulates Pancreas Development through Inactivation of Yap
- (2012) N. M. George et al. MOLECULAR AND CELLULAR BIOLOGY
- Cell Intrinsic Role of COX-2 in Pancreatic Cancer Development
- (2012) R. Hill et al. MOLECULAR CANCER THERAPEUTICS
- LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
- (2012) Dahu Chen et al. NATURE MEDICINE
- LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap
- (2012) H B Nguyen et al. ONCOGENE
- Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas
- (2012) H J Maier et al. ONCOGENE
- Down-Regulation of Yes Associated Protein 1 Expression Reduces Cell Proliferation and Clonogenicity of Pancreatic Cancer Cells
- (2012) Caroline H. Diep et al. PLoS One
- The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis
- (2012) M. Rajurkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structures of YAP protein domains reveal promising targets for development of new cancer drugs
- (2012) Marius Sudol et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions
- (2011) Chunling Yi et al. CANCER CELL
- Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression
- (2011) Akihisa Fukuda et al. CANCER CELL
- c-Raf, but Not B-Raf, Is Essential for Development of K-Ras Oncogene-Driven Non-Small Cell Lung Carcinoma
- (2011) Rafael B. Blasco et al. CANCER CELL
- Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
- (2011) Marina Lesina et al. CANCER CELL
- Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF
- (2011) D. Lai et al. CANCER RESEARCH
- Yes-Associated Protein 1 Exhibits Oncogenic Property in Gastric Cancer and Its Nuclear Accumulation Associates with Poor Prognosis
- (2011) W. Kang et al. CLINICAL CANCER RESEARCH
- Early Requirement of Rac1 in a Mouse Model of Pancreatic Cancer
- (2011) Irina Heid et al. GASTROENTEROLOGY
- A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription
- (2011) Y. Bao et al. JOURNAL OF BIOCHEMISTRY
- Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
- (2011) Eleni Maniati et al. JOURNAL OF CLINICAL INVESTIGATION
- Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
- (2011) Simon A. Jones et al. JOURNAL OF CLINICAL INVESTIGATION
- Yes-Associated Protein 1 Is Widely Expressed in Human Brain Tumors and Promotes Glioblastoma Growth
- (2011) Brent A. Orr et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
- (2011) Inamul Haque et al. Molecular Cancer
- The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene
- (2011) X Zhang et al. ONCOGENE
- Yes-associated protein promotes cell proliferation by activating Fos Related Activator-1 in oral squamous cell carcinoma
- (2011) Lei Zhang et al. ORAL ONCOLOGY
- C-Raf Is Required for the Initiation of Lung Cancer by K-Ras G12D
- (2011) Florian A. Karreth et al. Cancer Discovery
- Hippo Pathway Effector Yap Is an Ovarian Cancer Oncogene
- (2010) C. A. Hall et al. CANCER RESEARCH
- Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer
- (2010) Yang Wang et al. CANCER SCIENCE
- YAP is a candidate oncogene for esophageal squamous cell carcinoma
- (2010) Tomoki Muramatsu et al. CARCINOGENESIS
- The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
- (2010) Nailing Zhang et al. DEVELOPMENTAL CELL
- The Hippo Signaling Pathway in Development and Cancer
- (2010) Duojia Pan DEVELOPMENTAL CELL
- CXCL17 and ICAM2 Are Associated With a Potential Anti-Tumor Immune Response in Early Intraepithelial Stages of Human Pancreatic Carcinogenesis
- (2010) Nobuyoshi Hiraoka et al. GASTROENTEROLOGY
- Structural insights into the YAP and TEAD complex
- (2010) Z. Li et al. GENES & DEVELOPMENT
- A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP
- (2010) B. Zhao et al. GENES & DEVELOPMENT
- YAP1 and VGLL3, encoding two cofactors of TEAD transcription factors, are amplified and overexpressed in a subset of soft tissue sarcomas
- (2010) Zofia Hélias-Rodzewicz et al. GENES CHROMOSOMES & CANCER
- Stage-specific Control of Connective Tissue Growth Factor (CTGF/CCN2) Expression in Chondrocytes by Sox9 and β-Catenin
- (2010) Bau-Lin Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
- (2010) P. K. Mazur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
- (2010) L. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis
- (2010) V Tomlinson et al. Cell Death & Disease
- Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene
- (2009) Dawang Zhou et al. CANCER CELL
- FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt
- (2009) Huadong Pei et al. CANCER CELL
- The Role of Tumor Cell-Derived Connective Tissue Growth Factor (CTGF/CCN2) in Pancreatic Tumor Growth
- (2009) K. L. Bennewith et al. CANCER RESEARCH
- Gemcitabine Plus Celecoxib in Patients With Advanced or Metastatic Pancreatic Adenocarcinoma
- (2008) Tomislav Dragovich et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- The Emerging Role of the Hippo Pathway in Cell Contact Inhibition, Organ Size Control, and Cancer Development in Mammals
- (2008) Qi Zeng et al. CANCER CELL
- YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
- (2008) Toshihiko Yokoyama et al. CARCINOGENESIS
- TEAD mediates YAP-dependent gene induction and growth control
- (2008) B. Zhao et al. GENES & DEVELOPMENT
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started