Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Immunology
Jelka Hartwig, Madlen Loebel, Sophie Steiner, Sandra Bauer, Zehra Karadeniz, Carsten Roeger, Carsten Skurk, Carmen Scheibenbogen, Franziska Sotzny
Summary: The study showed that metformin can reduce ROS/RNS levels in immune cells by activating FOXO3. This may contribute to the beneficial clinical effects of metformin on longevity, cardiovascular health, and cancer risk.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Chang Min Lee, Jongsung Lee, Mi-Ae Kang, Hee Taek Kim, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, See-Hyoung Park
Summary: Linifanib has been shown to efficiently inhibit receptor tyrosine kinases, and in this study, its anti-cancer effects in ovarian cancer were investigated. Linifanib was found to inhibit proliferation and induce apoptosis in SKOV3 cells, as well as cause DNA damage and increase intracellular ROS levels.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Review
Genetics & Heredity
Victoria Simoes Bernardo, Flaviene Felix Torres, Danilo Gruenig Humberto Da Silva
Summary: This review highlights the importance of oxidative stress in human health and disease, focusing on the extensively studied transcription factor FoxO3, which plays a vital role in regulating gene networks involved in cellular metabolism, cell death, and stress resistance. The review also discusses the regulatory mechanisms of FoxO3 expression and activity, such as post-translational modifications and non-coding RNAs. Additionally, the article explores the interaction between FoxO3 and reactive oxygen species, suggesting potential pathogenic mechanisms for various diseases and the utility of FoxO3-regulated signaling pathways as therapeutic targets and diagnostic biomarkers.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Plant Sciences
Maria C. Romero-Puertas, Maria Angeles Pelaez-Vico, Diana M. Pazmino, Maria Rodriguez-Serrano, Laura Terron-Camero, Rocio Bautista, Aurelio Gomez-Cadenas, M. Gonzalo Claros, Jose Leon, Luisa M. Sandalio
Summary: The synthetic auxin 2,4-D triggers plant growth defects such as leaf epinasty and stem curvature, with ACX1 identified as a key source of ROS production and involvement in auxin-related signaling pathways. Different organelles play distinct roles in plant responses to 2,4-D, with ACX1 regulating protein degradation associated with auxin signaling.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Plant Sciences
Laura C. Terron-Cameron, M. Angeles Pelaez-Vico, A. Rodriguez-Gonzalez, Coral del Val, Luisa M. Sandalio, Maria C. Romero-Puertasl
Summary: Reactive oxygen species (ROS) act as secondary messengers that activate signal transduction and alter gene expression. The chemical identity and subcellular origin of ROS determine the transcriptome response. Transcriptomic studies on altered ROS metabolism in plant peroxisomes reveal common transcriptional footprints involved in metabolic pathways, gene regulation, and plant responses to abiotic stresses. Human orthologs of peroxisomal-dependent proteins are associated with cancer pathologies. Peroxisomal footprints provide valuable insights into peroxisomal functions in cellular metabolism under normal and stress conditions.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Dermatology
Li Zhang, Xiaoling Liu, Min Huang, Rui Wang, Wenwei Zhu, Yu Li, Lin Shen, Chengxin Li
Summary: In this study, it was found that under hyperlipidemia, metformin has significant antiproliferation and proapoptosis effects by reducing reactive oxygen species (ROS) level and increasing autophagy. These effects are mediated by the FOXO3-dependent pathway.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Cell Biology
Nicholas D. Demers, Victoria Riccio, Doo Sin Jo, Sushil Bhandari, Kelsey B. Law, Weifang Liao, Choy Kim, G. Angus McQuibban, Seong-Kyu Choe, Dong-Hyung Cho, Peter K. Kim
Summary: Recent studies suggest that the peroxisomal matrix protein import machinery plays a role in activating pexophagy, a type of selective autophagy that degrades damaged peroxisomes. Our research shows that the loss of PEX13, a component of the peroxisomal matrix import system, leads to the degradation of healthy peroxisomes. We found that this loss results in the accumulation of ubiquitinated PEX5 on peroxisomes, leading to an increase in peroxisome-dependent reactive oxygen species and the induction of pexophagy.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Kazusato Oikawa, Shino Goto-Yamada, Yasuko Hayashi, Daisuke Takahashi, Yoshitaka Kimori, Michitaro Shibata, Kohki Yoshimoto, Atsushi Takemiya, Maki Kondo, Kazumi Hikino, Akira Kato, Keisuke Shimoda, Haruko Ueda, Matsuo Uemura, Keiji Numata, Yoshinori Ohsumi, Ikuko Hara-Nishimura, Shoji Mano, Kenji Yamada, Mikio Nishimura
Summary: Pexophagy plays a pivotal role in selectively removing ROS-generating peroxisomes under high-intensity light, which protects plants from oxidative damage during photosynthesis.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Juan Xie, Penghui Bai, Chenjie Wang, Ning Chen, Weifeng Chen, Ming Duan, Hu Wang
Summary: This study investigates the effect of doping SrTiO3 with an extremely low concentration of NiP on the catalytic activity of water splitting under visible light irradiation. It is found that the transformation of oxygen species and the construction of reactive lattice oxygen play a crucial role in improving the hydrogen generation performance. Adjusting the ratio of different oxygen species is an effective strategy to fabricate high-performance photocatalysts for H-2 evolution.
ACS APPLIED ENERGY MATERIALS
(2022)
Review
Engineering, Biomedical
Shiyong Zhang, Liying Wang, Yunze Kang, Jun Wu, Ziji Zhang
Summary: Reactive oxygen species (ROS) have significant roles in physiological and pathophysiological processes. Recent studies have shown that ROS plays a crucial role in the development and progression of osteoarthritis (OA) by mediating extracellular matrix degradation, mitochondrial dysfunction, chondrocyte apoptosis, and OA progression. Nanomaterials with ROS-scavenging ability and antioxidant effects have shown promising results in OA treatment. However, current research on nanomaterials as ROS scavengers for OA is not uniform, and the timing and potential of their clinical use remain inconsistent. This review aims to provide a reference for further studies and promote the early clinical use of nanomaterials for OA treatment.
ACTA BIOMATERIALIA
(2023)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Inorganic & Nuclear
Jiale Liu, Mengyao Huang, Xinyu Zhang, Zhongyu Hua, Zeran Feng, Yi Dong, Tiedong Sun, Xiao Sun, Chunxia Chen
Summary: The dual effects of reactive oxygen species (ROS) in living organisms, which can cause oxidative imbalances and be regulated to attack tumors and bacteria, have attracted significant research attention. Polyoxometalates (POMs) have shown great potential in modulating ROS and have been investigated for disease treatment and sensing diagnostics, providing valuable insights into therapeutic and diagnostic technologies.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Andrey V. V. Kuznetsov, Sabzali Javadov, Raimund Margreiter, Judith Hagenbuchner, Michael J. J. Ausserlechner
Summary: Analyzing the function, structure, and intracellular organization of mitochondria is crucial for understanding energy metabolism and transfer. Differences between in situ and in vitro observations of mitochondria necessitate careful interpretation of experimental and clinical data. Crosstalk between mitochondria and the cell environment plays a vital role in regulating metabolism and physiology. Therefore, analyzing mitochondria in their natural setting is important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Reinhard Angermann, Anna Lena Huber, Yvonne Nowosielski, Stefan Salcher, Thomas Gasser, Christof Seifarth, Martina T. Kralinger, Claus Zehetner
Summary: Intravitreal brolucizumab leads to a sustained reduction in systemic VEGF-A levels, while aflibercept only provides short-term reduction. This may have implications for safety and long-term effects.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Engineering, Biomedical
Daniel Nothdurfter, Christian Ploner, Debora C. Coraca-Huber, Doris Wilflingseder, Thomas Mueller, Martin Hermann, Judith Hagenbuchner, Michael J. Ausserlechner
Summary: This paper presents a novel 3D printed neuroblastoma-tumor-environment model and a biofabrication platform suitable for studying tumor angiogenesis and metastasis.
Article
Biochemistry & Molecular Biology
Isabel Heidegger, Georgios Fotakis, Anne Offermann, Jermaine Goveia, Sophia Daum, Stefan Salcher, Asma Noureen, Hetty Timmer-Bosscha, Georg Schaefer, Annemiek Walenkamp, Sven Perner, Aleksandar Beatovic, Matthieu Moisse, Christina Plattner, Anne Krogsdam, Johannes Haybaeck, Sieghart Sopper, Stefanie Thaler, Markus A. Keller, Helmut Klocker, Zlatko Trajanoski, Dominik Wolf, Andreas Pircher
Summary: This study provides a comprehensive analysis of prostate cancer tumor endothelial cells (TEC) and identifies potential therapeutic targets, specifically the CXCL12/CXCR4 interaction, to interfere with tumor angiogenesis in prostate cancer. Understanding the cell-to-cell communication networks in the tumor microenvironment contributes to the development of new therapeutic approaches for prostate cancer.
Review
Immunology
M. Fodor, S. Salcher, H. Gottschling, A. Mair, M. Blumer, S. Sopper, S. Ebner, A. Pircher, R. Oberhuber, D. Wolf, S. Schneeberger, T. Hautz
Summary: The liver has a large repertoire of resident immune cells that play a critical role in maintaining immune balance and responding to inflammation. Machine perfusion (MP) has been used to preserve and evaluate the quality of organs, including livers, prior to transplantation. However, the impact of MP on the liver's immune cell repertoire and its role in inflammation during MP is not well understood. This review discusses the role of hepatic immune cells in inflammatory conditions and ischemia reperfusion injury in liver transplantation, and highlights the potential impact of MP on immune cell modification and future immune modulation of the liver.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Andrey Kuznetsov, Raimund Margreiter, Michael J. Ausserlechner, Judith Hagenbuchner
Summary: Mitochondria play a crucial role in energy production and participate in various cellular processes, including redox regulation, signal transduction, and cellular metabolism. They exhibit cell/tissue-specific functions and interact with other cellular components, influencing overall cell physiology.
Article
Chemistry, Multidisciplinary
Klara Kohoutova, Vojtech Docekal, Michael J. Ausserlechner, Nora Kaiser, Andrej Tekel, Raju Mandal, Matej Horvath, Veronika Obsilova, Jan Vesely, Judith Hagenbuchner, Tomas Obsil
Summary: Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Inhibition of FOXO3 is a promising strategy for enhancing antitumor immune responses and suppressing therapy resistance in cancer cells. (4-propoxy)phenylpyrimidinylguanidine has been identified as a FOXO3 inhibitor in cancer cells. The synthesis and structure-activity relationship study of its derivatives showed that some compounds are more potent than the parent compound in inhibiting FOXO3-induced gene transcription. These findings may contribute to the development of therapeutics for inhibiting FOX transcription factors.
Article
Oncology
Stefan Salcher, Gregor Sturm, Lena Horvath, Gerold Untergasser, Christiane Kuempers, Georgios Fotakis, Elisa Panizzolo, Agnieszka Martowicz, Manuel Trebo, Georg Pall, Gabriele Gamerith, Martina Sykora, Florian Augustin, Katja Schmitz, Francesca Finotello, Dietmar Rieder, Sven Perner, Sieghart Sopper, Dominik Wolf, Andreas Pircher, Zlatko Trajanoski
Summary: This study investigates the immune cell phenotypes in non-small cell lung cancer (NSCLC) and identifies cellular components associated with tumor histology and genotypes. The study also reveals the plasticity of tissue-resident neutrophils (TRNs) and their association with anti-programmed cell death ligand 1 (PD-L1) treatment failure.
Editorial Material
Biochemistry & Molecular Biology
Andrey V. Kuznetsov, Michael J. Ausserlechner
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Volani, Christa Malfertheiner, Giulia Caprioli, Soren Fjelstrup, Peter P. Pramstaller, Johannes Rainer, Giuseppe Paglia
Summary: Volumetric absorptive microsampling (VAMS) is a minimally invasive sample collection method for blood biomolecules analysis. This study investigated the stability of VAMS samples during short-term storage and compared the metabolome obtained from capillary blood collected from the fingertip to those of plasma and venous blood. The results showed that VAMS samples are stable at room temperature for up to 6 hours and capillary blood provides better coverage of the metabolome compared to plasma.
Article
Dermatology
Deborah Minzaghi, Petra Pavel, Christopher Kremslehner, Florian Gruber, Sophie Oberreiter, Judith Hagenbuchner, Barbara Del Frari, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: Atopic dermatitis (AD) is a complex disease characterized by chronic recurring eczema and pruritus. This study found that AD patients have oxidative and mitochondrial stress in the skin, as well as reduced antioxidant response, which further exacerbates the pathological changes in the skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Chemistry, Medicinal
Paul Kapitza, Amelie Scherfler, Stefan Salcher, Sieghart Sopper, Monika Cziferszky, Klaus Wurst, Ronald Gust
Summary: The reactivities of gold complexes with different ligands were analyzed in cell culture medium. Complexes 6 and 7 showed significant reactions, while interactions with non-thiol containing amino acids were not detected. Complex 8 exhibited strong stability and contributed to the biological effects of complex 7. The gold(III) species were reduced by GSH and showed promising activity against drug-resistant tumors.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
T. Hautz, S. Salcher, M. Fodor, G. Sturm, S. Ebner, A. Mair, M. Trebo, G. Untergasser, S. Sopper, B. Cardini, A. Martowicz, J. Hofmann, S. Daum, M. Kalb, T. Resch, F. Krendl, A. Weissenbacher, G. Otarashvili, P. Obrist, B. Zelger, D. Oefner, Z. Trajanoski, J. Troppmair, R. Oberhuber, A. Pircher, D. Wolf, S. Schneeberger
Summary: This study comprehensively characterized the immune cell population and their dynamic changes during liver NMP. It was found that neutrophils decreased significantly during NMP, while anti-inflammatory/tolerogenic monocytes/macrophages increased. The findings may contribute to future immune-interventional studies.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Marzia De Bortoli, Viviana Meraviglia, Katarina Mackova, Laura S. Frommelt, Eva Konig, Johannes Rainer, Chiara Volani, Patrizia Benzoni, Maja Schlittler, Giada Cattelan, Benedetta M. Motta, Claudia Volpato, Werner Rauhe, Andrea Barbuti, Serena Zacchigna, Peter P. Pramstaller, Alessandra Rossini
Summary: This study used human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to establish a model for incomplete penetrance in arrhythmogenic cardiomyopathy (ACM). The results showed molecular and functional differences between ACM and asymptomatic carriers of the same mutation (ASY) hiPSC-CMs, including a higher amount of mutated PKP2 mRNA, a lower expression of the connexin-43 protein, a lower overall density of sodium current, a higher intracellular lipid accumulation, and sarcomere disorganization in ACM compared to ASY hiPSC-CMs. Differentially expressed genes were also found, supporting a predisposition for a fatty phenotype in ACM hiPSC-CMs. This indicates that hiPSC-CMs are a suitable model to study incomplete penetrance in ACM.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Urology & Nephrology
Vladimir Vukovic, Essi Hantikainen, Athina Raftopoulou, Martin Gogele, Johannes Rainer, Francisco S. Domingues, Peter P. Pramstaller, Vanessa Garcia-Larsen, Cristian Pattaro
Summary: Population-based study found that total daily protein intake and protein intake from animal sources, fish, and poultry were positively associated with fasting serum creatinine levels, and negatively associated with estimated glomerular filtration rate.
JOURNAL OF NEPHROLOGY
(2023)
