Article
Food Science & Technology
Zaira Lopez, Michelle Salazar N. Zuniga, Antoni Femenia, Gustavo J. Acevedo-Hernandez, Jaime Godinez A. Flores, M. Eduardo Cano, Peter Knauth
Summary: Aloe vera products are popular due to their beneficial effects, mainly attributed to the active compound acemannan. High temperatures during the drying process have advantages but can also lead to structural changes and increased cytotoxicity. It is recommended to use suitable temperatures to preserve the structure and activity of aloe vera products.
Article
Polymer Science
Francesca Comas-Serra, Paula Estrada, Rafael Minjares-Fuentes, Antoni Femenia
Summary: This study evaluated the content and degree of acetylation (DA) of acemannan in 15 different commercial beverages containing Aloe vera. Flavoured beverages had low levels of acemannan and were fully deacetylated in most cases, likely due to the addition of fruit juices. Unflavoured beverages had variable levels of acemannan, with some samples containing very low amounts. Legislation regarding Aloe vera products is limited, leaving consumers uncertain about the true properties of the products they purchase.
Article
Veterinary Sciences
B. Quaye, O. Opoku, V. Benante, B. Adjei-Mensah, M. A. Amankrah, B. Ampadu, E. Awenkanab, C. C. Atuahene
Summary: Aloe vera gel extract can replace antibiotics in broiler chickens, improving growth performance and carcass traits, as well as positively affecting haemato-biochemical parameters.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Polymer Science
Petruta Preda, Ana-Maria Enciu, Cristiana Tanase, Maria Dudau, Lucian Albulescu, Monica-Elisabeta Maxim, Raluca Nicoleta Darie-Nita, Oana Brincoveanu, Marioara Avram
Summary: This study aimed to investigate and develop amorphous and crosslinked hydrogels based on natural compounds, such as sodium alginate, aloe vera gel powder, and chitosan, for tumor spheroid formation. The results showed that adding chitosan allowed the formation of spheroids at pH 5, while low viscosity and pH 12 aloe vera gels also promoted spheroid formation. Crosslinked hydrogel variants enhanced spheroid formation efficiency.
Review
Chemistry, Medicinal
Saeideh Sabbaghzadegan, Haide Golsorkhi, Mohammad Hossein Soltani, Mohammad Kamalinejad, Mohsen Bahrami, Ali Kabir, Majid Dadmehr
Summary: Cardiovascular diseases are the most prevalent causes of morbidity and mortality in both men and women, associated with various risk factors. Aloe vera gel, with its multiple biological activities, has shown beneficial effects on cardiovascular disease risk factors, but further high-quality studies are needed to firmly establish its clinical efficacy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Analytical
Vishnu Sujeesh, Godwin Ponraj, Hongliang Ren
Summary: This article presents the design and fabrication procedure of a novel soft-pressure sensor using Aloe vera gel and Glycerin as the solvent. The performance of sensor prototypes with varying solvent concentrations and geometric parameters is compared. The proposed sensor is entirely soft and can be designed to conform to any desired geometry.
Article
Biochemistry & Molecular Biology
Duoduo Zhang, Xingtao Zhou, Ke Zhang, Yongkang Yu, Steve W. Cui, Shaoping Nie
Summary: This study found that polysaccharides from Aloe vera gel can protect intestinal epithelial cells from oxidative stress and mitochondrial dysfunction by activating the Nrf2-mitochondrial axis, improving the impaired intestinal barrier function in inflammatory bowel disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, General & Internal
Chia-Chi Chiu, Yi-Wen Hsiao, Yu-Chuan Wen, Tsung-Yen Chang, Shih-Hsiang Chen, Tang-Her Jaing
Summary: This study evaluated the effectiveness of topical Aloe vera gel in preventing chemotherapy-induced hyperpigmentation (CIH). The results showed that continuous application of Aloe vera gel can reduce the visibility of hyperpigmentation caused by chemotherapy, highlighting its potential as a treatment for CIH.
Article
Engineering, Chemical
Alina Hadi, Anjum Nawab, Feroz Alam, Kishwar Zehra
Summary: Biodegradable films based on sodium alginate and aloe vera were prepared and characterized. The addition of aloe vera gel improved the mechanical and physico-chemical properties of the films, enhancing the tensile strength and reducing the water vapor permeability, making the film more effective as a moisture barrier.
POLYMER ENGINEERING AND SCIENCE
(2022)
Review
Plant Sciences
Walter Jose Martinez-Burgos, Josilene Lima Serra, Ronald M. Marsiglia, Pedro Montoya, Zulma Sarmiento-Vasquez, Oranys Marin, Euler Gallego-Cartagena, Carlos D. Paternina-Arboleda
Summary: Aloe vera is a plant with rich bioactive compounds and has important applications in medicine, cosmetics, and the food industry. Its use as a functional ingredient or fortifier in the food industry has been a growing trend. In addition, research on the science and innovation of the aloe vera industry is continuously being conducted.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Pharmacology & Pharmacy
Tulshi Chakraborty, Sumeet Gupta, Anroop Nair, Samrat Chauhan, Vipin Saini
Summary: The study showed that a topical gel formulation containing Aloe vera with insulin-loaded nanoemulsion had significant therapeutic effects on wound healing in diabetic rats, with good spreadability, permeation, and stability. This synergistic approach could be a promising and effective treatment for wounds in diabetic patients.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Plant Sciences
Anri Hattingh, Jean-Pierre Laux, Clarissa Willers, Josias Hamman, Dewald Steyn, Hannlie Hamman
Summary: The study found that combining Aloe vera gel with Bulbine frutescens aqueous extract can enhance the wound healing properties of Aloe vera gel.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Polymer Science
Siti Fatma Abd Karim, Juferi Idris, Junaidah Jai, Mohibah Musa, Ku Halim Ku Hamid
Summary: This study investigates the use of Aloe vera gel and soluble potato starch to improve the mechanical stability and water solubility of thermoplastic starch. The results show that the addition of Aloe vera gel enhances the mechanical properties, water solubility, and heat resistance of TPS films, making them suitable for biodegradable food packaging applications.
Article
Chemistry, Applied
Heng Liu, Shaohua Liu, Bingyang Du, Kuntian Dong, Yong Wang, Yuanhu Zhang
Summary: The study found that aloe vera gel treatment not only increased apple browning-related indicators, but also affected the antioxidant capacity of apples, leading to an exacerbation of superficial scald.
Article
Chemistry, Medicinal
Maria Cristina Pinheiro Pereira Reis-Mansur, Christian Campos Firmino Gomes, Fiammetta Nigro, Eduardo Ricci-Junior, Zaida Maria Faria de Freitas, Elisabete Pereira dos Santos
Summary: In order to enhance the effectiveness and safety of sun protection products, researchers have been exploring traditional organic sunscreens as well as green products containing natural compounds. Nanoemulsions have been developed as a suitable vehicle for encapsulating natural compounds, such as buriti oil and Aloe vera extract. The formulation of an oil-in-water nanoemulsion containing 3% buriti oil and 10% Aloe vera extract was optimized through ultrasonic processing, resulting in improved chemical characteristics, efficacy, and safety.
Article
Materials Science, Biomaterials
Yinghan Chan, Sin Wi Ng, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Pradeep Kumar, Viness Pillay, Gaurav Gupta, Ridhima Wadhwa, Meenu Mehta, Peter Wark, Alan Hsu, Nicole G. Hansbro, Philip Michael Hansbro, Kamal Dua, Jithendra Panneerselvam
Summary: This study successfully formulated celastrol into liquid crystalline nanoparticles, with in-vitro release studies and molecular simulations confirming its potential therapeutic efficacy in treating asthma, demonstrating significant therapeutic effects.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2021)
Review
Endocrinology & Metabolism
David O. C. Yong, Sanggetha R. Saker, Dinesh K. Chellappan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Hira Choudhury, Manisha Pandey, Yik L. Chan, Trudi Collet, Gaurav Gupta, Brian G. Oliver, Peter Wark, Nicole Hansbro, Alan Hsu, Philip M. Hansbro, Kamal Dua, Farrukh Zeeshan
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Review
Pharmacology & Pharmacy
Phui Qi Ng, Laura Soon Cheau Ling, Jestin Chellian, Thiagarajan Madheswaran, Jithendra Panneerselvam, Anil Philip Kunnath, Gaurav Gupta, Saurabh Satija, Meenu Mehta, Philip Michael Hansbro, Trudi Collet, Kamal Dua, Dinesh Kumar Chellappan
CURRENT PHARMACEUTICAL DESIGN
(2020)
Article
Biochemistry & Molecular Biology
Ridhima Wadhwa, Keshav Raj Paudel, Li Hian Chin, Chian Ming Hon, Thiagarajan Madheswaran, Gaurav Gupta, Jithendra Panneerselvam, Thangavelu Lakshmi, Sachin Kumar Singh, Monica Gulati, Harish Dureja, Alan Hsu, Meenu Mehta, Krishnan Anand, Hari Prasad Devkota, Jestin Chellian, Dinesh Kumar Chellappan, Philip M. Hansbro, Kamal Dua
Summary: The study demonstrates that Naringenin-loaded liquid crystalline nanoparticles possess both anti-inflammatory and anticancer potential, reducing inflammatory markers and inhibiting lung cancer progression efficiently.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Jin-Ying Wong, Zhao Yin Ng, Meenu Mehta, Shakti D. Shukla, Jithendra Panneerselvam, Thiagarajan Madheswaran, Gaurav Gupta, Poonam Negi, Pradeep Kumar, Viness Pillay, Alan Hsu, Nicole G. Hansbro, Peter Wark, Mary Bebawy, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan
Review
Medicine, Research & Experimental
Li-Yen Lee, Geena Suet Yin Hew, Meenu Mehta, Shakti D. Shukla, Saurabh Satija, Navneet Khurana, Krishnan Anand, Harish Dureja, Sachin Kumar Singh, Vijay Mishra, Pankaj Kumar Singh, Monica Gulati, Parteek Prasher, Alaa A. A. Aljabali, Murtaza M. Tambuwala, Lakshmi Thangavelu, Jithendra Panneerselvam, Gaurav Gupta, Flavia C. Zacconi, Madhur Shastri, Niraj Kumar Jha, Dikaia Xenaki, Ronan MacLoughlin, Brian G. Oliver, Dinesh Kumar Chellappan, Kamal Dua
Summary: Eosinophils play a critical role in immune and inflammatory responses, regulated by Th2 cytokines. By studying the interactions of eosinophils with their extracellular environment, various therapies targeting respiratory diseases have been developed. Therapeutic agents targeting eosinophils have shown promise in clinical testing, bridging the gap between theory and practice in respiratory disease treatment.
Review
Chemistry, Medicinal
Farrukh Zeeshan, Thiagarajan Madheswaran, Jithendra Panneerselvam, Rajeev Taliyan, Prashant Kesharwani
Summary: This article discusses the salient characteristics, design, and categories of albumin-based nanocarriers (ANCs) in the context of their application in cancer management. It also explores the fabrication methods, use in gene, cancer, and multimodal therapy, cancer diagnosis, and imaging of ANCs. Lastly, the article briefly covers the formulations, commercial products, and clinical testing of ANCs.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Microbiology
Jamunadevi Jayaraman, Santhosh Sigamani, Dhandapani Ramamurthy
Summary: This study isolated and identified magnetotactic bacteria with metal tolerance from fresh water sediments in Salem region of Tamil Nadu. Among the strains tested, Pseudomonas aeruginosa and Achromobacter xylosoxidans showed the highest metal tolerance and may play a significant role in environmental bioremediation.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Keshav Raj Paudel, Ridhima Wadhwa, Xin Nee Tew, Natalie Jia Xin Lau, Thiagarajan Madheswaran, Jithendra Panneerselvam, Farrukh Zeeshan, Pradeep Kumar, Gaurav Gupta, Krishnan Anand, Sachin K. Singh, Niraj Kumar Jha, Ronan MacLoughlin, Nicole G. Hansbro, Gang Liu, Shakti D. Shukla, Meenu Mehta, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: This study explored the anti-cancer activity of Rutin-loaded liquid crystalline nanoparticles (LCNs) in non-small cell lung cancer cell line, showing promising anti-proliferative and anti-migratory activities, induction of apoptosis, and inhibition of colony formation. These findings provide important insights for further mechanistic studies of Rutin-LCNs as a potential therapeutic option for NSCLC.
Editorial Material
Biotechnology & Applied Microbiology
Yinghan Chan, Meenu Mehta, Keshav Raj Paudel, Thiagarajan Madheswaran, Jithendra Panneerselvam, Gaurav Gupta, Qian Peter Su, Philip Michael Hansbro, Ronan McLoughlin, Kamal Dua, Dinesh Kumar Chellappan
Article
Environmental Sciences
Keshav R. Paudel, Meenu Mehta, Geena Hew Suet Yin, Lee Li Yen, Vamshikrishna Malyla, Vyoma K. Patel, Jithendra Panneerselvam, Thiagarajan Madheswaran, Ronan MacLoughlin, Niraj Kumar Jha, Piyush Kumar Gupta, Sachin Kumar Singh, Gaurav Gupta, Pradeep Kumar, Brian G. Oliver, Philip M. Hansbro, Dinesh Kumar Chellappan, Kamal Dua
Summary: The study shows that berberine-loaded liquid crystalline nanoparticles can effectively inhibit the proliferation and migration of non-small cell lung cancer cells, and also affect proteins associated with lung cancer progression. These findings suggest that utilizing nanotechnology-based delivery systems for anti-cancer compounds can overcome the challenges of poor solubility and bioavailability, leading to improved efficacy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Bapi Gorain, Manisha Pandey, Ng Hui Leng, Cho Wei Yan, Kuek Wee Nie, Simran Jeet Kaur, Vincent Marshall, Sreenivas Patro Sisinthy, Jithendra Panneerselvam, Nagashekhara Molugulu, Prashant Kesharwani, Hira Choudhury
Summary: Management of chronic wounds has significant social and economic implications, and traditional medicines combined with nanotechnology offer new opportunities for wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Juman Mohammed Rasmi Alamil, Keshav Raj Paudel, Yinghan Chan, Dikaia Xenaki, Jithendra Panneerselvam, Sachin Kumar Singh, Monica Gulati, Niraj Kumar Jha, Deepak Kumar, Parteek Prasher, Gaurav Gupta, Raniya Malik, Brian George Oliver, Philip Michael Hansbro, Kamal Dua, Dinesh Kumar Chellappan
Summary: Inflammation is a crucial part of the immune system and dysregulated inflammation is a major concern. Chronic inflammatory diseases are a leading cause of morbidity and mortality worldwide. Traditional anti-inflammatory medications have adverse effects and limited effectiveness, making the search for new alternatives important. Agarwood oil, derived from agarwood trees, has bioactive compounds that regulate chronic inflammation and can potentially treat various inflammatory disorders.
Article
Environmental Sciences
Silambarasan Tamil Selvan, Balakumaran Manickam Dakshinamoorthi, Ravikumar Chandrasekaran, Sanjivkumar Muthusamy, Dhandapani Ramamurthy, Sendilkumar Balasundaram
Summary: In this study, a pilot-scale treatment method was used to test the biosorption of textile dye and carbon dioxide using Chlorella vulgaris RDS03. The results showed that Chlorella vulgaris RDS03 achieved a high biosorption capacity for textile dye and effectively utilized carbon dioxide to produce biomass, bioethanol, and biodiesel.
INTERNATIONAL JOURNAL OF PHYTOREMEDIATION
(2023)
Review
Nutrition & Dietetics
Dvya Delilaa Clarence, Keshav Raj Paudel, Bikash Manandhar, Sachin Kumar Singh, Hari Prasad Devkota, Jithendra Panneerselvam, Vivek Gupta, Nitin Chitranshi, Nitin Verma, Sonia Saad, Gaurav Gupta, Philip Michael Hansbro, Brian Gregory Oliver, Thiagarajan Madheswaran, Kamal Dua, Dinesh Kumar Chellappan
Summary: Chronic inflammation of the respiratory tract is a major public health issue that can lead to various chronic respiratory diseases. The conventional drug therapies only address the symptoms, while the combination of nutraceuticals and nanoparticles has gained attention as it can not only improve symptoms, but also has anti-inflammatory and antioxidant properties with fewer adverse effects.
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
