Leptin resistance in diet-induced obesity: the role of hypothalamic inflammation

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

(2016) Dongsheng Cai et al.   Aging-US

Fractalkine (CX3CL1) Is Involved in the Early Activation of Hypothalamic Inflammation in Experimental Obesity

(2014) Joseane Morari et al.   DIABETES

Central Inflammation and Leptin Resistance Are Attenuated by Ginsenoside Rb1 Treatment in Obese Mice Fed a High-Fat Diet

(2014) Yizhen Wu et al.   PLoS One

Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress

(2013) Min Zheng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

(2013) Joshua P. Thaler et al.   DIABETES

Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter

(2013) X. Shi et al.   DIABETOLOGIA

Teasaponin Reduces Inflammation and Central Leptin Resistance in Diet-Induced Obese Male Mice

(2013) Yinghua Yu et al.   ENDOCRINOLOGY

Hormones and diet, but not body weight, control hypothalamic microglial activity

(2013) Yuanqing Gao et al.   GLIA

Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

(2013) Isin Çakir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin signaling and leptin resistance

(2013) Yingjiang Zhou et al.   Frontiers of Medicine

Neuroinflammatory basis of metabolic syndrome

(2013) Sudarshana Purkayastha et al.   Molecular Metabolism

Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity

(2012) Karen K. Ryan et al.   Cell Metabolism

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Increased Hypothalamic Inflammation Associated with the Susceptibility to Obesity in Rats Exposed to High-Fat Diet

(2012) Xiaoke Wang et al.   Experimental Diabetes Research

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

(2012) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

IKKβ/NF-κB disrupts adult hypothalamic neural stem cells to mediate a neurodegenerative mechanism of dietary obesity and pre-diabetes

(2012) Juxue Li et al.   NATURE CELL BIOLOGY

Dietary Factors Affect Food Reward and Motivation to Eat

(2012) Rahul Pandit et al.   Obesity Facts

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

Hypothalamic dysfunction in obesity

(2012) Lynda M. Williams   PROCEEDINGS OF THE NUTRITION SOCIETY

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

An overview on how components of the melanocortin system respond to different high energy diets

(2011) José K. van den Heuvel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neurobiology of overeating and obesity: The role of melanocortins and beyond

(2011) Rahul Pandit et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Altered hypothalamic function in diet-induced obesity

(2011) L A Velloso et al.   INTERNATIONAL JOURNAL OF OBESITY

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB

(2011) Sudarshana Purkayastha et al.   NATURE MEDICINE

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptors, inflammation, metabolism and obesity

(2011) Manuel Fresno et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

(2010) Shinsuke Oh-I et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids

(2010) Sun Ju Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance

(2010) Paty Karoll Picardi et al.   FEBS LETTERS

Leptin in human physiology and therapeutics

(2010) Tina A. Dardeno et al.   FRONTIERS IN NEUROENDOCRINOLOGY

The Epidemiology of Obesity

(2010) Dang M. Nguyen et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

(2010) G. Sabio et al.   GENES & DEVELOPMENT

NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia

(2010) Pil-Geum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance

(2010) M W A de Backer et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes

(2010) Mireille Bélanger et al.   JOURNAL OF NEUROCHEMISTRY

TNF-α transiently induces endoplasmic reticulum stress and an incomplete unfolded protein response in the hypothalamus

(2010) R.G. Denis et al.   NEUROSCIENCE

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling

(2009) Clett Erridge et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat

(2009) Juan Hidalgo et al.   BRAIN BEHAVIOR AND IMMUNITY

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

(2009) Nathalie Pamir et al.   ENDOCRINOLOGY

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Stressing the Brain, Fattening the Body

(2008) Ling Yang et al.   CELL

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY