Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Medicine, Research & Experimental
Huojun Zhang, Ling Zhou, Yuhao Zhou, Lingling Wang, Weiling Jiang, Lu Liu, Shuang Yue, Pengdou Zheng, Huiguo Liu
Summary: In this study, we found that IH aggravates NAFLD via RIPK3-dependent necroptosis-modulated Nrf2/NF Kappa B signaling pathway. RIPK3 downregulation significantly reduced hepatocyte necroptosis, and ameliorated oxidative stress and inflammation through modulating Nrf2/NF Kappa B pathway in vitro and in vivo. Additionally, pretreatment with TBHQ effectively blocked the generation of oxidative productions and inflammatory cytokines.
Article
Food Science & Technology
Bangyan Li, Qianqian Mao, Dandan Zhou, Min Luo, Renyou Gan, Hangyu Li, Siyu Huang, Adila Saimaiti, Ao Shang, Huabin Li
Summary: Oolong tea and dark tea can prevent AFLD induced by chronic alcohol exposure by modulating gut microbiota.
Article
Biochemistry & Molecular Biology
John A. Collins, Maryna Kapustina, Jesalyn A. Bolduc, James F. W. Pike, Brian O. Diekman, Kimberlee Mix, Susan Chubinskaya, Emrah Eroglu, Thomas Michel, Leslie B. Poole, Cristina M. Furdui, Richard F. Loeser
Summary: SIRT6, a nuclear localized deacetylase protein, is a critical regulator of aging processes. It can promote resistance to oxidative stress and influences specific members of the Prx catalytic cycle in chondrocytes to maintain redox homeostasis. Age and oxidative stress conditions alter SIRT6 activity, suggesting potential therapeutic targets for maintaining redox balance in joint tissues and preventing osteoarthritis progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Food Science & Technology
Yuan Yuan, Fuquan Wu, Fengpei Zhang, Xiaomin Li, Xiaoping Wu, Junsheng Fu
Summary: Melanin from Inonotus hispidus fruiting bodies (IHFM) has a protective effect on acute alcoholic liver injury in mice. It acts through the gut-microbiota-liver axis and improves liver injury by enhancing alcohol metabolism, reducing inflammation, and strengthening antioxidant activities. IHFM also activates the Nrf2 signaling pathway and inhibits the TLR4/NF-kappa beta signaling pathway. Additionally, IHFM increases the relative abundance of Lactobacillus reuteri and Lactobacillus johnsonii, which are associated with antioxidant effects and reduced inflammation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yunjia Li, Menghan Yang, Haiyan Lin, Weixin Yan, Guanghui Deng, Haixin Ye, Hao Shi, Chaofeng Wu, Guoliang Ma, Shu Xu, Qinxiang Tan, Zhuowei Gao, Lei Gao
Summary: Limonin has a protective effect on NAFLD by reducing lipid droplet accumulation, regulating lipogenic transcription factors, suppressing inflammation and oxidative stress, and reversing unfavorable changes through activating the NRF2/HO-1 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Daniel Salete-Granado, Cristina Carbonell, David Puertas-Miranda, Victor-Jose Vega-Rodriguez, Marina Garcia-Macia, Ana Belen Herrero, Miguel Marcos
Summary: Ethanol consumption induces oxidative stress through the generation of reactive oxygen species (ROS) and contributes to the development of alcoholic liver disease (ALD) by causing steatosis and liver inflammation. Autophagy, a regulated process, plays a protective role in hepatocytes but not stellate cells against the harmful effects of ROS-induced oxidative stress, which include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, inflammation, and iron overload. Autophagy also has the potential to mitigate alcohol-induced damage in other organs, providing an additional layer of protection against ALD. Studies have shown that drugs targeting autophagy, such as rapamycin, can prevent ALD development in animal models, further supporting its protective potential. This systematic review analyzes the role of autophagy in regulating oxidative stress, its involvement in organ-organ crosstalk relevant to ALD, and the potential of autophagy-targeting therapeutic strategies.
Article
Biochemistry & Molecular Biology
Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Geum-Hwa Lee, Yeon Jun Jeong
Summary: Identifying effective biomarker-based phytochemicals from medicinal plants is a promising strategy to protect against liver injury. The combination of Vitis vinifera L. (VE) leaf and Centella asiatica (CE) extract (VCEC) shows synergistic protective effects against CCl4-induced acute liver injury in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Johanna C. Arroyave-Ospina, Zongmei Wu, Yana Geng, Han Moshage
Summary: Oxidative stress plays a major role in the pathophysiology of chronic liver diseases, particularly in non-alcoholic liver disease (NAFLD). The antioxidant response, regulated by the Nrf2/ARE pathway, is crucial in combating oxidative stress-induced damage.
Article
Biochemistry & Molecular Biology
Yunjia Li, Mengchen Qin, Weichao Zhong, Chang Liu, Guanghui Deng, Menghan Yang, Junjie Li, Haixin Ye, Hao Shi, Chaofeng Wu, Haiyan Lin, Yuyao Chen, Shaohui Huang, Chuying Zhou, Zhiping Lv, Lei Gao
Summary: The study indicates the important role of RAGE in alcoholic liver disease (ALD). Deficiency or inhibition of RAGE can alleviate hepatic inflammation and oxidative stress, as well as affect iron metabolism pathways, thereby improving liver injury.
Article
Immunology
Liping Liang, Shiwei Ye, Ruilai Jiang, Xiao Zhou, Junjie Zhou, Shuiyun Meng
Summary: This study explores the regulatory effects of liensinine (LIEN) on the progression of nonalcoholic fatty liver disease (NAFLD). The results show that LIEN can improve fatty liver by activating AMPK, reducing ROS production, and inhibiting inflammation. These findings suggest that LIEN could be a promising therapeutic strategy for NAFLD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qian Li, Jia-Xin Tan, Yong He, Fang Bai, Shi-Wei Li, Yi-Wen Hou, Long-Shan Ji, Ya-Ting Gao, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Miao Fang, Yue-Qiu Gao, Man Li
Summary: This study suggests that Atractylenolide III (ATL III) is a potential therapeutic drug for the treatment of NAFLD. ATL III can inhibit liver injury and lipid accumulation, and reduce oxidative stress, inflammation, and fibrosis. Its mechanism may be achieved by activating the hepatic AdipoR1-mediated AMPK/SIRT1 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yaning Biao, Jian Chen, Chenxu Liu, Ruilong Wang, Xue Han, Li Li, Yixin Zhang
Summary: Danshen zexie decoction (DZD), a Chinese herbal medicine, has been found to regulate lipid mechanism. In this study, it is demonstrated that DZD can reduce lipid accumulation, alleviate oxidative stress and inflammation, and inhibit pyroptosis in NAFLD rats. These effects might be attributed to the suppression of the ROS/NLRP3/IL-1β signaling pathway by the activation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Magdalena Quetglas-Llabres, Margalida Monserrat-Mesquida, Cristina Bouzas, Isabel Llompart, David Mateos, Miguel Casares, Lucia Ugarriza, J. Alfredo Martinez, Josep A. Tur, Antoni Sureda
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by liver fat deposition without alcohol consumption. This study aimed to assess the antioxidant and pro-inflammatory state in NAFLD patients following a 12-month lifestyle intervention based on adherence to a Mediterranean diet (AMD). The intervention resulted in improvements in anthropometric and biochemical parameters, with higher reductions in alanine aminotransferase (ALT) and C reactive protein (CRP) observed in participants with high AMD. Additionally, there were decreases in prooxidant and proinflammatory markers, as well as improvements in physical fitness and intrahepatic fat contents. These improvements were more significant in individuals with higher adherence to the Mediterranean diet.
Review
Pharmacology & Pharmacy
Junbin Yan, Yunmeng Nie, Minmin Luo, Zhiyun Chen, Beihui He
Summary: Excessive alcohol intake can cause alcoholic liver disease, and natural compounds may provide a potential treatment for ALD.
FRONTIERS IN PHARMACOLOGY
(2021)