Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling

Liensinine Prevents Vascular Inflammation by Attenuating Inflammatory Mediators and Modulating VSMC Function

(2021) Moon Young Jun et al.   Applied Sciences-Basel

Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder

(2020) Chenxu Ge et al.   Aging-US

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional loss of inactive rhomboid-like protein 2 mitigates obesity by suppressing pro-inflammatory macrophage activation-triggered adipose inflammation

(2020) Minxuan Xu et al.   Molecular Metabolism

Targeting DUSP7 signaling alleviates hepatic steatosis, inflammation and oxidative stress in high fat diet (HFD)-fed mice via suppression of TAK1

(2020) Liping Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

iRhom2 promotes hepatic steatosis by activating MAP3K7‐dependent pathway

(2020) Minxuan Xu et al.   HEPATOLOGY

Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission

(2020) Xinyue Liang et al.   PHARMACOLOGICAL RESEARCH

Activation of the AMP-related kinase (AMPK) induces renal vasodilatation and downregulates Nox-derived reactive oxygen species (ROS) generation

(2020) Claudia Rodríguez et al.   Redox Biology

SeP is elevated in NAFLD and participates in NAFLD pathogenesis through AMPK/ACC pathway

(2020) Yi Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin alleviates lead-induced mitochondrial fragmentation via AMPK/Nrf2 activation in SH-SY5Y cells

(2020) Luoyao Yang et al.   Redox Biology

Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin

(2020) Chenxu Ge et al.   Redox Biology

Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

(2020) Oren Rom et al.   Science Translational Medicine

Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease

(2018) Mario Masarone et al.   Oxidative Medicine and Cellular Longevity

Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy

(2018) Wei Liu et al.   Cell Death & Disease

Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice

(2018) Kaori Endo-Umeda et al.   Scientific Reports

Is TAK1 a Direct Upstream Kinase of AMPK?

(2018) Dietbert Neumann   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

(2018) Yang Wang et al.   Food & Function

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis

(2017) Peng Zhang et al.   NATURE MEDICINE

Mechanisms, Pathophysiology, and Management of Obesity

(2017) Steven B. Heymsfield et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatment of nonalcoholic fatty liver disease: role of AMPK

(2016) Brennan K. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum

(2016) Timothy Hardy et al.   Annual Review of Pathology-Mechanisms of Disease

Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease

(2016) Yaron Rotman et al.   GUT

A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease

(2016) Steven E. Trasino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Macrophage Activation in Pediatric Nonalcoholic Fatty Liver Disease (NAFLD) Correlates with Hepatic Progenitor Cell Response via Wnt3a Pathway

(2016) Guido Carpino et al.   PLoS One

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

(2015) Jing Zhou et al.   Autophagy

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Protective effect of liensinine on periodontitis through its antioxidant effect in mice

(2015) Liang Pang et al.   Journal of the Korean Society for Applied Biological Chemistry

Gastrodin Ameliorates Oxidative Stress and Proinflammatory Response in Nonalcoholic Fatty Liver Disease through the AMPK/Nrf2 Pathway

(2015) Li-Li Qu et al.   PHYTOTHERAPY RESEARCH

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis

(2014) Sayaka Inokuchi-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Resveratrol modulates autophagy and NF-κB activity in a murine model for treating non-alcoholic fatty liver disease

(2013) Lake Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis

(2013) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

Cell type-specific function of TAK1 in innate immune signaling

(2013) Adebusola A. Ajibade et al.   TRENDS IN IMMUNOLOGY

Regulation of NAD(P)H oxidases by AMPK in cardiovascular systems

(2012) Ping Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

TAK1, more than just innate immunity

(2012) Liang Dai et al.   IUBMB LIFE

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-κB and JNK/p38 MAPK pathways

(2010) Ke-Wu Zeng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet☆

(2010) Yu-Kun Jennifer Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells

(2009) Griselda Herrero-Martín et al.   EMBO JOURNAL

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

IL-6 Deficiency Attenuates Murine Diet-Induced Non-Alcoholic Steatohepatitis

(2009) Emmanuel Mas et al.   PLoS One