Article
Cell Biology
Rosario Avolio, Marta Ingle-Ferrnandiz, Annagiulia Ciocia, Olga Coll, Sarah Bonnin, Tanit Guitart, Anna Ribo, Fatima Gebauer
Summary: This study reveals that the RNA-binding protein CSDE1 enables oncogene-induced senescence (OIS) in mouse keratinocytes. They identified two molecular mechanisms by which CSDE1 promotes OIS and showed that depletion of YBX1 can rescue senescence and uncouple proliferation arrest from the senescence-associated secretory phenotype (SASP).
Article
Cell Biology
Ruifan Wu, Shengchun Feng, Fan Li, Gang Shu, Lina Wang, Ping Gao, Xiaotong Zhu, Canjun Zhu, Songbo Wang, Qingyan Jiang
Summary: Obesity is a global health problem associated with metabolic diseases. This study investigates the role of YBX1 in adipogenesis and adipose tissue expansion. The researchers found that YBX1 deficiency inhibited adipocyte differentiation and that YBX1 promotes adipogenesis through ULK1- and ULK2-mediated autophagy. The findings provide insights into the molecular mechanisms and functional importance of YBX1 in regulating autophagy and adipogenesis, highlighting its potential as a therapeutic target for obesity and metabolic diseases.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Akshaya Arva, Yasar Arfat T. Kasu, Jennifer Duncan, Mosleh A. Alkhatatbeh, Christopher S. Brower
Summary: This study reveals that Liat1 participates in nucleolar liquid-liquid phase separation regulated by Jmjd6, and also found that the lysyl-hydroxylase activity of Jmjd6 affects the function of Liat1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Hai-feng Shen, Wen-juan Zhang, Ying Huang, Yao-hui He, Guo-sheng Hu, Lei Wang, Bing-ling Peng, Jia Yi, Ting-ting Li, Rui Rong, Xiao-yan Chen, Jun-yi Liu, Wen-juan Li, Kenny Ohgi, Shao-Wei Li, Michael G. Rosenfeld, Wen Liu
Summary: Research has shown that the epigenetic regulator KDM5C can both activate estrogen receptor alpha (ER alpha) target genes and suppress type I interferons in breast cancer cells, contributing to cell growth and tumorigenesis. This dual activator and repressor function of KDM5C plays a role in cancer development.
Article
Oncology
Kimihiko Yoshida, Takaki Hiwasa, Masaaki Ito, Mitsunori Ushigome, Hirotaka Takizawa, Shu-Yang Li, Bo-Shi Zhang, Yasuo Iwadate, Kimihiko Funahashi, Hideaki Shimada
Summary: This study evaluated the clinical significance of serum anti-JMJD6 antibodies (s-JMJD6-Abs) in patients with colorectal cancer. The results showed that 37% of colorectal cancer patients tested positive for s-JMJD6-Abs, which may serve as an independent poor prognostic biomarker.
Article
Multidisciplinary Sciences
Nicolas Butel, Agnes Yu, Ivan Le Masson, Filipe Borges, Taline Elmayan, Christelle Taochy, Nial R. Gursanscky, Jiangling Cao, Shengnan Bi, Anne Sawyer, Bernard J. Carroll, Herve Vaucheret
Summary: The research reveals that there are discrepancies in the epigenetic behavior of transgenes and endogenous genes in Arabidopsis, indicating that they are regulated by different mechanisms.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Ann Mari Rosager, Rikke H. Dahlrot, Mia D. Sorensen, Julie A. Bangso, Steinbjorn Hansen, Bjarne W. Kristensen
Summary: JMJD6 is highly expressed in IDH-wildtype GBM, but it has no independent prognostic value.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Masayuki Sano, Kana Morishita, Satoshi Oikawa, Takayuki Akimoto, Kimio Sumaru, Yoshio Kato
Summary: MicroRNAs are small RNAs that regulate gene expression in eukaryotic cells, and their unique expression patterns make them potential molecular markers for specific cell states. A new miR-ON sensor, Csy4-miR-ON, has been developed for sensitive and high-contrast fluorescent detection of miRNAs in human cells, enabling imaging of various miRNAs in vitro and in vivo. This tool can be used for evaluating miRNA expression in diverse biological and medical applications.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Multidisciplinary Sciences
Alexander Plong, Kevin Rodriguez, Mark Alber, Weitao Chen, G. Venugopala Reddy
Summary: WUSCHEL concentration regulation is crucial for stem cell homeostasis in Arabidopsis shoot apical meristems. CLAVATA3 not only represses WUSCHEL transcription, but also regulates WUSCHEL by controlling its nuclear export and diffusion between adjacent cells.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Karin M. Kirschner, Holger Scholz
Summary: This article summarizes the role of WT1 in the development of visceral white adipose tissue and its supposed function as a regulator of white adipose identity. It also discusses the improved metabolic function and browning of epididymal white adipose tissue in Wt1 heterozygous mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Lisa-Marie Appel, Vedran Franke, Johannes Benedum, Irina Grishkovskaya, Xue Strobl, Anton Polyansky, Gregor Ammann, Sebastian Platzer, Andrea Neudolt, Anna Wunder, Lena Walch, Stefanie Kaiser, Bojan Zagrovic, Kristina Djinovic-Carugo, Altuna Akalin, Dea Slade
Summary: The heptad repeats of the C-terminal domain (CTD) of RNA polymerase II (Pol II) are extensively modified throughout the transcription cycle. The SPOC domain was identified as a CTD reader domain specifically binding to phosphorylated serine residues. The SPOC domains of DIDO, SHARP, and RBM15 can act as CTD readers and also recognize other phosphorylated binding partners.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Megan E. E. Dowdle, Charlotte R. R. Kanzler, Cole R. K. Harder, Samuel Moffet, Maya N. N. Walker, Michael D. D. Sheets
Summary: Bicaudal-C is a crucial RNA binding protein that regulates development in various organisms, from fruit flies to vertebrate embryos. It has a broad impact on developmental biology, influencing cell fates and being associated with defects in human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hans Felix Staehle, Heike Luise Pahl, Jonas Samuel Jutzi
Summary: Histone demethylases, particularly Jumonji C (JmjC) domain-containing proteins, play critical roles in myeloid malignancies and may serve as potential targets for drug interventions. However, understanding the context-dependent mechanisms of these proteins presents challenges that require further exploration.
Article
Oncology
Chenchen He, Wang Liu, Jiahao Sun, Da Zhang, Benyi Li
Summary: In this study, it was found that the RIOX2 gene was significantly upregulated in prostate cancer and was associated with disease-specific survival. The upregulation of this gene may be due to the upregulation of the c-Myc gene. Therefore, the expression of RIOX2 can serve as an independent prognostic factor for disease progression and prognosis in prostate cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiayang Liu, Zhao Huang, Hai-Ning Chen, Siyuan Qin, Yan Chen, Jingwen Jiang, Zhe Zhang, Maochao Luo, Qin Ye, Na Xie, Zong-Guang Zhou, Yuquan Wei, Ke Xie, Canhua Huang
Summary: ZNF37A plays a critical role in promoting metastasis in poorly differentiated colorectal cancer by enhancing TGF-beta signaling and activating cancer-associated fibroblasts through transcriptional repression of THSD4. This suggests ZNF37A as a potential biomarker for CRC progression and differentiation.
Article
Hematology
Lapo Alinari, Kiran V. Mahasenan, Fengting Yan, Vrajesh Karkhanis, Ji-Hyun Chung, Emily M. Smith, Carl Quinion, Porsha L. Smith, Lisa Kim, John T. Patton, Rosa Lapalombella, Bo Yu, Yun Wu, Satavisha Roy, Alessandra De Leo, Stefano Pileri, Claudio Agostinelli, Leona Ayers, James E. Bradner, Selina Chen-Kiang, Olivier Elemento, Tasneem Motiwala, Sarmila Majumder, John C. Byrd, Samson Jacob, Said Sif, Chenglong Li, Robert A. Baiocchi
Article
Multidisciplinary Sciences
Brian T. Nasipak, Teresita Padilla-Benavides, Karin M. Green, John D. Leszyk, Wenjie Mao, Silvana Konda, Said Sif, Scott A. Shaffer, Yasuyuki Ohkawa, Anthony N. Imbalzano
NATURE COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Scott E. LeBlanc, Qiong Wu, Pallavi Lamba, Said Sif, Anthony N. Imbalzano
NUCLEIC ACIDS RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Y. K. Banasavadi-Siddegowda, L. Russell, E. Frair, V. A. Karkhanis, T. Relation, J. Y. Yoo, J. Zhang, S. Sif, J. Imitola, R. Baiocchi, B. Kaur
Article
Oncology
Wei Huang, Devina Mehta, Said Sif, Lindsey N. Kent, Samson T. Jacob, Kalpana Ghoshal, Kamal D. Mehta
Review
Pharmacology & Pharmacy
Emily Smith, Wei Zhou, Polina Shindiapina, Said Sif, Chenglong Li, Robert A. Baiocchi
EXPERT OPINION ON THERAPEUTIC TARGETS
(2018)
Article
Oncology
Fengting Yan, Lapo Alinari, Mark E. Lustberg, Ludmila Katherine Martin, Hector M. Cordero-Nieves, Yeshavanth Banasavadi-Siddegowda, Selene Virk, Jill Barnholtz-Sloan, Erica Hlavin Bell, Jeffrey Wojton, Naduparambil K. Jacob, Arnab Chakravarti, Michal O. Nowicki, Xin Wu, Rosa Lapalombella, Jharna Datta, Bo Yu, Kate Gordon, Amy Haseley, John T. Patton, Porsha L. Smith, John Ryu, Xiaoli Zhang, Xiaokui Mo, Guido Marcucci, Gerard Nuovo, Chang-Hyuk Kwon, John C. Byrd, E. Antonio Chiocca, Chenglong Li, Said Sif, Samson Jacob, Sean Lawler, Balveen Kaur, Robert A. Baiocchi
Article
Biochemistry & Molecular Biology
Jihyun Chung, Vrajesh Karkhanis, Sookil Tae, Fengting Yan, Porsha Smith, Leona W. Ayers, Claudio Agostinelli, Stefano Pileri, Gerald V. Denis, Robert A. Baiocchi, Said Sif
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Agnieszka Bronisz, Heather A. Carey, Jakub Godlewski, Said Sif, Michael C. Ostrowski, Sudarshana M. Sharma
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Tanya Seth-Vollenweider, Sneha Joshi, Puneet Dhawan, Said Sif, Sylvia Christakos
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Jihyun Chung, Vrajesh Karkhanis, Robert A. Baiocchi, Said Sif
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Vrajesh Karkhanis, Lapo Alinari, Hatice Gulcin Ozer, Jihyun Chung, Xiaoli Zhang, Said Sif, Robert A. Baiocchi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Cell Biology
Balsam Rizeq, Said Sif, Gheyath K. Nasrallah, Allal Ouhtit
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cell Biology
Harshita Shailesh, Kodappully S. Siveen, Said Sif
Summary: PRMT5 is overexpressed in breast cancer and promotes proliferative signaling by epigenetically silencing pathway antagonists, DKK1 and DKK3. Inhibition of PRMT5 alters breast cancer cell growth characteristics and induces cell death by restoring the expression of DKK1 and DKK3.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)