PRMT5–PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells

PTEN/Akt-p27kip1Signaling Promote the BM-MSCs Senescence and Apoptosis in SLE Patients

(2015) Wei Tan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

(2014) Fengting Yan et al.   CANCER RESEARCH

Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro

(2014) Xiaosi Han et al.   JOURNAL OF NEURO-ONCOLOGY

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Tumor-Specific Activation of the C-JUN/MELK Pathway Regulates Glioma Stem Cell Growth in a p53-Dependent Manner

(2013) Chunyu Gu et al.   STEM CELLS

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Targeting the AKT Pathway in Glioblastoma

(2011) Kelli A. McDowell et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

(2011) K. Masui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation

(2010) J-J Lee et al.   CELL DEATH AND DIFFERENTIATION

Survival of Patients with Newly Diagnosed Glioblastoma Treated with Radiation and Temozolomide in Research Studies in the United States

(2010) S. A. Grossman et al.   CLINICAL CANCER RESEARCH

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

(2010) Hui-Kuan Lin et al.   NATURE

Switching on Epigenetic Therapy

(2009) Sascha Karberg   CELL

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PRMT5 is required for cell-cycle progression and p53 tumor suppressor function

(2009) A. Scoumanne et al.   NUCLEIC ACIDS RESEARCH

Histone Deacetylase Inhibitors Augment Antitumor Efficacy of Herpes-based Oncolytic Viruses

(2008) Akihiro Otsuki et al.   MOLECULAR THERAPY

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE