“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

Periodontitis

(2014) Christoph Schaudinn et al.   JOURNAL OF THE AMERICAN DENTAL ASSOCIATION

A critical analysis of current in vitro and in vivo angiogenesis assays

(2010) Carolyn A. Staton et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The use of rodent models to investigate host-bacteria interactions related to periodontal diseases

(2010) Dana T. Graves et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Determinants of serum IgG responses to periodontal bacteria in a nationally representative sample of US adults

(2010) Christian Vlachojannis et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST)

(2010) Moïse Desvarieux et al.   JOURNAL OF HYPERTENSION

Modulation of host matrix metalloproteinases by bacterial virulence factors relevant in human periodontal diseases

(2010) Y Ding et al.   ORAL DISEASES

Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175

(2010) J. Abranches et al.   Oral microbiology and immunology

Periodontitis and incidence of cerebrovascular disease in men

(2009) Monik Jimenez et al.   ANNALS OF NEUROLOGY

Immune and Inflammatory Mechanisms of Atherosclerosis

(2009) Elena Galkina et al.   Annual Review of Immunology

Vitamin C intake attenuates the degree of experimental atherosclerosis induced by periodontitis in the rat by decreasing oxidative stress

(2009) Daisuke Ekuni et al.   ARCHIVES OF ORAL BIOLOGY

Heat-shock proteins can promote as well as regulate autoimmunity

(2009) Rajesh Rajaiah et al.   AUTOIMMUNITY REVIEWS

Toll-Like Receptor-2 Mediates Inflammation and Matrix Degradation in Human Atherosclerosis

(2009) Claudia Monaco et al.   CIRCULATION

Inflammation Impairs Reverse Cholesterol Transport In Vivo

(2009) Fiona C. McGillicuddy et al.   CIRCULATION

Translational Mini-Review Series on Immunology of Vascular Disease: Inflammation, infections and Toll-like receptors in cardiovascular disease

(2009) J. R. Ward et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of MCP-1 in cardiovascular disease: molecular mechanisms and clinical implications

(2009) Jianli Niu et al.   CLINICAL SCIENCE

Oxidative Stress, Endothelial Dysfunction and Atherosclerosis

(2009) Victor Victor et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondrial heat shock protein (HSP) 70 synergizes with HSP60 in transducing endothelial cell apoptosis induced by anti-HSP60 autoantibody

(2009) Jean-Eric Alard et al.   FASEB JOURNAL

Doxycyline inhibits mononuclear cell-mediated connective tissue breakdown

(2009) Ying Gu et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Prevotella intermediaupregulates MMP-1 and MMP-8 expression in human periodontal ligament cells

(2009) Su-Min Guan et al.   FEMS MICROBIOLOGY LETTERS

The gingipains: scissors and glue of the periodontal pathogen,Porphyromonas gingivalis

(2009) Rebecca E Fitzpatrick et al.   Future Microbiology

Intranasal immunization withPorphyromonas gingivalisand atherosclerosis

(2009) Yukiko Koizumi et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Chlamydial and Periodontal Pathogens Induce Hepatic Inflammation and Fatty Acid Imbalance in Apolipoprotein E-Deficient Mice

(2009) K. Hyvarinen et al.   INFECTION AND IMMUNITY

Sonic extracts from a bacterium related to periapical disease activate gelatinase A and inactivate tissue inhibitor of metalloproteinases TIMP-1 and TIMP-2

(2009) Y. Sato et al.   INTERNATIONAL ENDODONTIC JOURNAL

Human Caspases: Activation, Specificity, and Regulation

(2009) Cristina Pop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacteraemia due to dental flossing

(2009) Kenneth Crasta et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Heterogeneity of systemic inflammatory responses to periodontal therapy

(2009) Jan H. Behle et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Mouse model of experimental periodontitis induced byPorphyromonas gingivalis/Fusobacterium nucleatuminfection: bone loss and host response

(2009) David Polak et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Variable Cell Responses to P. gingivalis Lipopolysaccharide

(2009) L. Kocgozlu et al.   JOURNAL OF DENTAL RESEARCH

TLR Cross-Talk Specifically Regulates Cytokine Production by B Cells from Chronic Inflammatory Disease Patients

(2009) M. Jagannathan et al.   JOURNAL OF IMMUNOLOGY

Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries

(2009) E. Gaetti-Jardim et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Periodontitis-induced lipid peroxidation in rat descending aorta is involved in the initiation of atherosclerosis

(2009) D. Ekuni et al.   JOURNAL OF PERIODONTAL RESEARCH

Porphyromonas gingivalisfimbriae-dependent interleukin-6 autocrine regulation by increase of gp130 in endothelial cells

(2009) Y-S. Ho et al.   JOURNAL OF PERIODONTAL RESEARCH

Periodontal bacteremia and various vascular diseases

(2009) T. Iwai   JOURNAL OF PERIODONTAL RESEARCH

Enhanced monocyte migration and pro-inflammatory cytokine production byPorphyromonas gingivalisinfection

(2009) A. Pollreisz et al.   JOURNAL OF PERIODONTAL RESEARCH

Periodontitis as a risk factor for cerebrovascular accident: a case-control study in the Indian population

(2009) A. R. Pradeep et al.   JOURNAL OF PERIODONTAL RESEARCH

Degradation of Vascular Endothelial Thrombomodulin by Arginine- and Lysine-Specific Cysteine Proteases FromPorphyromonas gingivalis

(2009) Megumi Inomata et al.   JOURNAL OF PERIODONTOLOGY

Comparisons of Subgingival Microbial Profiles of Refractory Periodontitis, Severe Periodontitis, and Periodontal Health Using the Human Oral Microbe Identification Microarray

(2009) Ana Paula V. Colombo et al.   JOURNAL OF PERIODONTOLOGY

Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

(2009) Steven Offenbacher et al.   JOURNAL OF PERIODONTOLOGY

Serum Antibodies to Periodontal Bacteria as Diagnostic Markers of Periodontitis

(2009) Bruce A. Dye et al.   JOURNAL OF PERIODONTOLOGY

Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis

(2009) M. DIEUDÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Regulation of cellular immunity prevents Helicobacter pylori-induced atherosclerosis

(2009) K. Ayada et al.   LUPUS

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exploring the oral bacterial flora: current status and future directions

(2009) NB Parahitiyawa et al.   ORAL DISEASES

Oral bacterial cultures in nontraumatic brain abscesses: results of a first-line study

(2009) Andreas Albert Mueller et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

Differential virulence and innate immune interactions of type I and II fimbrial genotypes ofPorphyromonas gingivalis

(2009) M. Wang et al.   Oral microbiology and immunology

Identification of a Shared Genetic Susceptibility Locus for Coronary Heart Disease and Periodontitis

(2009) Arne S. Schaefer et al.   PLoS Genetics

Mechanisms of Endothelial Dysfunction, Injury, and Death

(2008) Jordan S. Pober et al.   Annual Review of Pathology-Mechanisms of Disease

Periodontitis is associated with platelet activation

(2008) Dimitris Papapanagiotou et al.   ATHEROSCLEROSIS

Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study

(2008) Zhiying You et al.   ATHEROSCLEROSIS

Tooth loss, hypertension and risk for stroke in a Korean population

(2008) Heon Choe et al.   ATHEROSCLEROSIS

Intracellular survival and vascular cell-to-cell transmission of Porphyromonas gingivalis

(2008) Ling Li et al.   BMC MICROBIOLOGY

Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells

(2008) Jan Oscarsson et al.   BMC MICROBIOLOGY

Cyclooxygenase-2 inhibition increases lipopolysaccharide-induced atherosclerosis in mice

(2008) J. M. Gitlin et al.   CARDIOVASCULAR RESEARCH

Lipid raft-dependent uptake, signalling and intracellular fate ofPorphyromonas gingivalisin mouse macrophages

(2008) Min Wang et al.   CELLULAR MICROBIOLOGY

Bacteremia Associated With Toothbrushing and Dental Extraction

(2008) Peter B. Lockhart et al.   CIRCULATION

Age-Dependent Associations Between Chronic Periodontitis/Edentulism and Risk of Coronary Heart Disease

(2008) Thomas Dietrich et al.   CIRCULATION

Stimulation of Toll-Like Receptor 2 in Human Platelets Induces a Thromboinflammatory Response Through Activation of Phosphoinositide 3-Kinase

(2008) Price Blair et al.   CIRCULATION RESEARCH

Circulating oxidized low-density lipoprotein: a biomarker of atherosclerosis and cardiovascular risk?

(2008) Eline Verhoye et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Oxidative Modification of LDL: Its Pathological Role in Atherosclerosis

(2008) Hiroyuki Itabe   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Refining exposure definitions for studies of periodontal disease and systemic disease associations

(2008) Ryan T. Demmer et al.   COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY

Treatment of periodontal disease results in improvements in endothelial dysfunction and reduction of the carotid intima-media thickness

(2008) Stefania Piconi et al.   FASEB JOURNAL

Upregulation of S100 calcium-binding protein A9 is required for induction of smooth muscle cell proliferation by a periodontal pathogen

(2008) Hiroaki Inaba et al.   FEBS LETTERS

Fusobacterium nucleatumenhances invasion of human gingival epithelial and aortic endothelial cells byPorphyromonas gingivalis

(2008) Atsushi Saito et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Atherosclerosis as a disease of failed endogenous repair

(2008) Andrey et al.   Frontiers in Bioscience-Landmark

Nasal Immunization with Porphyromonas gingivalis Outer Membrane Protein Decreases P. gingivalis-Induced Atherosclerosis and Inflammation in Spontaneously Hyperlipidemic Mice

(2008) Y. Koizumi et al.   INFECTION AND IMMUNITY

Pro-atherogenic lung and oral pathogens induce an inflammatory response in human and mouse mast cells

(2008) Anna Oksaharju et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Diverse and Novel Oral Bacterial Species in Blood following Dental Procedures

(2008) F. K. Bahrani-Mougeot et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Bleeding on probing differentially relates to bacterial profiles: the Oral Infections and Vascular Disease Epidemiology Study

(2008) Ryan T. Demmer et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Severe periodontitis in young adults is associated with sub-clinical atherosclerosis

(2008) Francesco Cairo et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

A systematic review and meta-analyses on C-reactive protein in relation to periodontitis

(2008) Spiros Paraskevas et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Antibody levels to single bacteria or in combination evaluated against myocardial infarction

(2008) Lise Lund Håheim et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Synergistic Pathogenicity of Porphyromonas gingivalis and Fusobacterium nucleatum in the Mouse Subcutaneous Chamber Model

(2008) Zvi Metzger et al.   JOURNAL OF ENDODONTICS

Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis

(2008) Linda L. Humphrey et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

The periodontal pathogen Porphyromonas gingivalis cleaves apoB-100 and increases the expression of apoM in LDL in whole blood leading to cell proliferation

(2008) T. Bengtsson et al.   JOURNAL OF INTERNAL MEDICINE

Molecular and cellular mechanisms of the thrombotic complications of atherosclerosis

(2008) Peter Libby   JOURNAL OF LIPID RESEARCH

The Association between Self-reported Periodontitis and Coronary Heart Disease-From MY Health Up Study-

(2008) Toshihiko Senba et al.   JOURNAL OF OCCUPATIONAL HEALTH

Periodontitis and the Risk for Non-Fatal Stroke in Korean Adults

(2008) Seon-Ju Sim et al.   JOURNAL OF PERIODONTOLOGY

Elevated platelet and leukocyte response to oral bacteria in periodontitis

(2008) E. A. NICU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The periodontal pathogenPorphyromonas gingivalissensitises human blood platelets to epinephrine

(2008) M. Nylander et al.   PLATELETS

Pathogen induction of CXCR4/TLR2 cross-talk impairs host defense function

(2008) G. Hajishengallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Porphyromonas gingivalis infection and prothrombotic effects in human aortic smooth muscle cells

(2008) Georg A. Roth et al.   THROMBOSIS RESEARCH

Update on bacteraemia related to dental procedures

(2008) Ingar Olsen   TRANSFUSION AND APHERESIS SCIENCE

The Roles of Pathogen-Associated Molecular Patterns in Atherosclerosis

(2008) Clett Erridge   TRENDS IN CARDIOVASCULAR MEDICINE

Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients

(2008) K. Nakano et al.   Oral microbiology and immunology

Toll-like receptor 2 plays a critical role in the progression of atherosclerosis that is independent of dietary lipids

(2007) Xinyan Liu et al.   ATHEROSCLEROSIS

Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model

(2007) Monika Madan et al.   ATHEROSCLEROSIS

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

(2007) Sridevi Devaraj et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Periodontitis and Vascular Events (PAVE) Pilot Study: Adverse Events

(2007) James D. Beck et al.   JOURNAL OF PERIODONTOLOGY