Article
Cell Biology
Zeyuan Gao, Xiuhong Weng, Donghu Yu, Zhiyong Pan, Mingjuan Zhao, Bo Cheng, Zhiqiang Li
Summary: Periodontitis is significantly associated with the risk of lung and digestive system cancers, as well as potentially various brain diseases. A study found that P. gingivalis LPS can promote glioma cell proliferation and migration, and increase levels of TNF-alpha, TGF-beta, MMP2, MMP9, and phosphorylation of Akt. Poor periodontal status was significantly higher in glioma patients compared to those with benign tumors, suggesting a possible association between periodontal infection and glioma progression.
Article
Immunology
Priscilla L. Phillips, Xiao-jun Wu, Leticia Reyes
Summary: Porphyromonas gingivalis and its secreted T9SS components may interact with AoSMCs and play a role in infection-induced dysregulation of VSMC plasticity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Van Thi Ai Tran, You Jung Kang, Hyun-Kyoung Kim, Hyung-Ryong Kim, Hansang Cho
Summary: Porphyromonas gingivalis, a gram-negative bacterium in the human oral cavity, may contribute to the development of chronic periodontitis and neurological diseases by inducing neuroinflammation and neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Anna B. Meier, Dorota Zawada, Maria Teresa De Angelis, Laura D. Martens, Gianluca Santamaria, Sophie Zengerle, Monika Nowak-Imialek, Jessica Kornherr, Fangfang Zhang, Qinghai Tian, Cordula M. Wolf, Christian Kupatt, Makoto Sahara, Peter Lipp, Fabian J. Theis, Julien Gagneur, Alexander Goedel, Karl-Ludwig Laugwitz, Tatjana Dorn, Alessandra Moretti
Summary: The lineage of human epicardium was studied through time course single-cell analysis of epicardioids. The mesothelial envelope of the vertebrate heart, known as the epicardium, serves as the source of multiple cardiac cell lineages during embryonic development and is essential for myocardial growth and repair. Using self-organizing human pluripotent stem cell-derived epicardioids, researchers were able to observe the morphological, molecular, and functional patterning of the epicardium and myocardium, similar to the left ventricular wall. This study provides insights into the specification and differentiation process of different cell lineages in epicardioids, as well as the functional cross-talk between different cardiac cell types.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Gina R. Lewin, Kendall S. Stocke, Richard J. Lamont, Marvin Whiteley
Summary: This study characterizes the behavior and virulence of the periodontal pathogen Porphyromonas gingivalis during human infection. It reveals that P. gingivalis is highly expressed in diseased samples, with genes related to virulence factors and growth/matabolism being actively expressed. The study also shows that the gene expression of P. gingivalis during periodontitis is highly conserved with logarithmic laboratory growth, suggesting that simple test tube growth can be used as a model for studying P. gingivalis biology.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Sejal Patel, Derek Howard, Nityananda Chowdhury, Casey Derieux, Bridgette Wellslager, Ozlem Yilmaz, Leon French
Summary: Porphyromonas gingivalis, a bacterium associated with periodontal disease, is suspected to be linked to the development of Alzheimer's disease. Research on gingipain proteases and differentially expressed genes in brain samples with detected P. gingivalis sequences have revealed potential connections to periodontal disease, Alzheimer's disease, and dementia. Analysis of gene expression in mice and humans has highlighted specific neuroanatomical patterns related to P. gingivalis infection and its possible association with Alzheimer's disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yajun Zhao, Yilin Shi, Huiqi Yang, Mengmeng Liu, Lanbo Shen, Shengben Zhang, Yue Liu, Jie Zhu, Jing Lan, Jianhua Li, Shaohua Ge
Summary: This study proposes a method of encapsulating stem cell spheroids in microcapsules using a metal-phenolic network nanofilm, in order to maintain their stemness in an inflammatory microenvironment. The biodegradable MPN biointerface formed acts as a protective barrier for the cells, and exhibits antioxidative, antibacterial, and anti-inflammatory activities, effectively remodeling the inflammatory microenvironment and maintaining stemness.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Suyog Basnet, Evan Michael Vallenari, Urusha Maharjan, Sunita Sharma, Olaf Schreurs, Dipak Sapkota
Summary: S100A16 is a member of the S100 protein family and is expressed in various human tissues, particularly those rich in epithelial cells. It is differentially expressed in the majority of human cancers and has been implicated in tumorigenesis, including cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition. Additionally, S100A16 expression has prognostic potential in various cancer types.
Article
Oncology
Shegan Gao, Ke Liu, Yelin Jiao, Pan Chen, Bianli Gu, Yiwen Liu, Gaofeng Liang, Linlin Shi, Fuyou Zhou, Richard J. Lamont, Huizhi Wang, Yi-Jun Qi
Summary: This study found that Porphyromonas gingivalis infection increased TGF13 secretion and activated TGF13/Smad signaling in esophageal squamous cell carcinoma (ESCC). It also demonstrated that P. gingivalis enhanced the expression of GARP, which further activated TGF13/Smad signaling. The activation of TGF13 signaling was found to be associated with poor prognosis in ESCC patients. Targeting either P. gingivalis or GARP-TGF13 signaling could be a potential treatment strategy for ESCC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yishu Luo, Chen Huang
Summary: The study showed that circSFMBT2 is upregulated in neointimal tissue and PDGF-BB-treated VSMCs, and its knockdown inhibits VSMC proliferation and migration while enhancing the expression of contractile markers. CircSFMBT2 was found to regulate VSMC proliferation and migration through the miR-331/HDAC5/Aggf1 axis, suggesting a potential novel target for treating proliferative vascular diseases.
Article
Biochemistry & Molecular Biology
Kazuki Watanabe, Sayaka Katagiri, Hirokazu Takahashi, Naoki Sasaki, Shogo Maekawa, Rina Komazaki, Masahiro Hatasa, Yoichiro Kitajima, Yusuke Maruyama, Takahiko Shiba, Keiji Komatsu, Yujin Ohsugi, Kenichi Tanaka, Ayumi Matsuzawa, Tomomitsu Hirota, Haruka Tohara, Yuichiro Eguchi, Keizo Anzai, Atsuhiko Hattori, Takanori Iwata
Summary: The study suggests that infection with Pg is a risk factor for metabolic syndrome and skeletal muscle metabolic dysfunction via gut microbiome alteration. Experimental results show that mice fed a high-fat diet and administered Pg displayed insulin resistance, impaired glucose tolerance, and fat infiltration in muscles, along with activation of the TNF-alpha signaling pathway in the soleus muscle.
Article
Dentistry, Oral Surgery & Medicine
Anne Katrine Danielsen, Christian Damgaard, Laura Massarenti, Peter ostrup, Peter Riis Hansen, Palle Holmstrup, Claus H. Nielsen
Summary: This study found that B cells in patients with periodontitis have enhanced cytokine responses to periodontitis-associated bacteria. B cells from severe patients, compared to moderate patients, produced more cytokines after stimulation with Porphyromonas gingivalis. Additionally, the frequency of IL-10-producing B cells in severe patients correlated negatively with clinical attachment loss.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Min Wang, Lili Li, Jun Qian, Nannan Wang, Jun Bao, Jiangyue Lu, Faming Chen, Yanfen Li, Yangheng Zhang, Fuhua Yan
Summary: In this study, the salivary microbiota from patients with periodontitis was transferred to obese mice induced by high-fat diet to investigate the influence on gut microbiome and liver metabolism. The results showed that periodontitis salivary microbiota altered gut microbiota composition and exacerbated intestinal barrier dysfunction, leading to activation of toll-like receptor 4 signaling and release of pro-inflammatory factors in the liver. Moreover, the upregulation of the tryptophan-kynurenine-AhR signal axis in the liver was associated with aggravated hepatic steatosis and dysregulation of glucolipid metabolism during NAFLD development. This study suggests that periodontitis salivary microbiota may worsen the pathological progression of NAFLD in the context of obesity, with the tryptophan-AhR pathway potentially playing a key role.
Article
Multidisciplinary Sciences
Anastasios Karydis, Indra Sandal, Jiwen Luo, Amanda Prislovsky, Amanda Gamboa, Edward F. Rosloniec, David D. Brand
Summary: The study found that carrying the shared epitope and inoculation with Porphyromonas gingivalis increased the percentage of Th17 cells, significantly increased bone loss, and allowed for the generation of CCP2 ACPAs not found in C57BL/6 or DBA/1 arthritic mouse serum.
Correction
Multidisciplinary Sciences
Thanuja D. K. Herath, Richard P. Darveau, Chaminda J. Seneviratne, Cun-Yu Wang, Yu Wang, Lijian Jin
Summary: The paper has been updated and can be accessed through the link at the top of the page.
SCIENTIFIC REPORTS
(2021)
