Inborn and acquired metabolic defects in cancer

IDH1 Mutations in Gliomas: When an Enzyme Loses Its Grip

(2010) Christian Frezza et al.   CANCER CELL

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Expression Profiling in Progressive Stages of Fumarate-Hydratase Deficiency: The Contribution of Metabolic Changes to Tumorigenesis

(2010) H. Ashrafian et al.   CANCER RESEARCH

The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor   and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth

(2010) J. Yang et al.   CANCER RESEARCH

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene

(2010) Sarah L Housley et al.   HISTOPATHOLOGY

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

(2010) Linda O'Flaherty et al.   HUMAN MOLECULAR GENETICS

IDH1andIDH2Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

(2010) Guido Marcucci et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations

(2010) Stefan Gross et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High glucose and renin release: the role of succinate and GPR91

(2010) János Peti-Peterdi   KIDNEY INTERNATIONAL

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

(2010) Jean-Pierre Bayley et al.   LANCET ONCOLOGY

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling

(2009) William G. Kaelin   CANCER CELL

SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis

(2009) Alex Henderson et al.   Familial Cancer

The genetic and metabolic signature of oncocytic transformation implicates HIF1α destabilization

(2009) Anna Maria Porcelli et al.   HUMAN MOLECULAR GENETICS

IDH1mutations at residue p.R132 (IDH1R132) occur frequently in high-grade gliomas but not in other solid tumors

(2009) Fonnet E. Bleeker et al.   HUMAN MUTATION

Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension

(2009) Zhongmin Tian et al.   HYPERTENSION

The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications

(2009) C. A. Stratakis et al.   JOURNAL OF INTERNAL MEDICINE

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

(2009) Ana M Cervera et al.   Molecular Cancer

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas

(2009) N Raimundo et al.   ONCOGENE

CANCER: Puzzling Patterns of Predisposition

(2009) P. J. Pollard et al.   SCIENCE

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α

(2008) Patrick J. Pollard et al.   BIOCHEMICAL JOURNAL

Cells Silenced for SDHB Expression Display Characteristic Features of the Tumor Phenotype

(2008) A. M. Cervera et al.   CANCER RESEARCH

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

The Histone Demethylases JMJD1A and JMJD2B Are Transcriptional Targets of Hypoxia-inducible Factor HIF

(2008) Sophie Beyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Germline SDHB Mutations and Familial Renal Cell Carcinoma

(2008) C. Ricketts et al.   JNCI-Journal of the National Cancer Institute

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY