Exploiting tumor metabolism: challenges for clinical translation

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Glutamine and cancer: cell biology, physiology, and clinical opportunities

(2013) Christopher T. Hensley et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Isocitrate dehydrogenase mutations in leukemia

(2013) Anna Sophia McKenney et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index

(2013) Lisa Martin et al.   JOURNAL OF CLINICAL ONCOLOGY

Understanding Metabolic Regulation and Its Influence on Cell Physiology

(2013) Christian M. Metallo et al.   MOLECULAR CELL

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

(2013) Jaekyoung Son et al.   NATURE

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

(2013) Jie Hu et al.   NATURE BIOTECHNOLOGY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

(2013) Nicola Ternette et al.   Cell Reports

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC- Transporter Using Positron Emission Tomography in Patients with Non-Small Cell Lung or Breast Cancer

(2012) S. Baek et al.   CLINICAL CANCER RESEARCH

(4S)-4-(3-18F-Fluoropropyl)-L-Glutamate for Imaging of xC Transporter Activity in Hepatocellular Carcinoma Using PET: Preclinical and Exploratory Clinical Studies

(2012) S. Baek et al.   JOURNAL OF NUCLEAR MEDICINE

How cancer metabolism is tuned for proliferation and vulnerable to disruption

(2012) Almut Schulze et al.   NATURE

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC

(2012) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Caveolin-1 and Cancer Metabolism in the Tumor Microenvironment: Markers, Models, and Mechanisms

(2011) Federica Sotgia et al.   Annual Review of Pathology-Mechanisms of Disease

Specific PET Imaging of xC−Transporter Activity Using a18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism

(2011) Norman Koglin et al.   CLINICAL CANCER RESEARCH

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PET Imaging of Glutaminolysis in Tumors by 18F-(2S,4R)4-Fluoroglutamine

(2011) B. P. Lieberman et al.   JOURNAL OF NUCLEAR MEDICINE

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Synthetase Is a Genetic Determinant of Cell Type–Specific Glutamine Independence in Breast Epithelia

(2011) Hsiu-Ni Kung et al.   PLoS Genetics

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

18F-FDG PET and PET/CT in the Evaluation of Cancer Treatment Response

(2009) S. Ben-Haim et al.   JOURNAL OF NUCLEAR MEDICINE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice

(2008) Pierre Sonveaux et al.   JOURNAL OF CLINICAL INVESTIGATION

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predictive and prognostic value of FDG-PET

(2008) Lioe-Fee de Geus-Oei   CANCER IMAGING