Article
Plant Sciences
Yunyan Deng, Tao Wang, Ping Zhao, Ying Du, LuLu Zhang, Zhiqui Qi, Mingshan Ji
Summary: This study reveals that Corynespora cassiicola, the causal agent of cucumber Corynespora leaf spot, exhibits resistance to multiple fungicides, posing a serious threat to effective disease control.
Article
Immunology
Qin Wang, Lu Wang, Lisha Lian, Xiaofeng Pu, Lu Tang, Yanmei Li, Yuan Liu
Summary: This study aimed to identify the pathogen causing ocular infection in a Chinese patient and describe its morphological characteristics. The isolated fungus, identified as Corynespora cassiicola, was found to have pseudoseptate thick-walled conidia when cultured on medium containing leaf leachate. Molecular biology techniques played a crucial role in accurate diagnosis of fungal infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Plant Sciences
Bingxue Sun, Guangxue Zhu, Xuewen Xie, Ali Chai, Lei Li, Tengfei Fan, Baoju Li, Shi Yanxia
Summary: Corynespora cassiicola, a foliar disease in cucumber, has become increasingly resistant to succinate dehydrogenase inhibitors. Resistance monitoring programs have identified nine genotypes with varying levels of resistance to SDHIs. Hebei Province in China was the first to detect a mutation in the sdhB subunit, and other genotypes have since been found. Multiple resistances have also been observed to other fungicides, accounting for a significant percentage of SDHI-resistant isolates.
Article
Immunology
Hongjun Ba, Huimin Peng, Liangping Cheng, Yuese Lin, Xuandi Li, Xiufang He, Shujuan Li, Huishen Wang, Youzhen Qin
Summary: This case report describes a 7-month-old infant presenting with symptoms of TM infection including recurrent cough, fever, and rash. Whole exome sequencing revealed complex mutations in the patient's CARD9 gene, but symptoms significantly improved after voriconazole treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingnan Huang, Juyong Zhao, Xue Wang, Lifeng Ma, Zhangtong Ma, Xiangnan Meng, Haiyan Fan
Summary: Energy metabolism is crucial for plant growth, development, and response to stress. SnRK1, an energy-sensitive regulator, plays a key role in controlling carbohydrate metabolism. However, the function of SnRK1 in cucumber remains unclear. This study used SnRK1 activator metformin and SnRK1 inhibitor trehalose to examine the role of SnRK1 signaling in cucumber. The results showed that SnRK1 activation inhibited cucumber growth and photosynthesis while reducing the levels of photosynthetic pigments and soluble sugars. SnRK1 activation also enhanced cucumber resistance to Corynespora cassiicola. Conversely, SnRK1 inhibition led to opposite effects. Overall, CsSnRK1 signaling is important for balancing cucumber growth and immune response, which can be exploited for developing disease-resistant cucumber varieties.
Article
Microbiology
Boxun Li, Yang Yang, Jimiao Cai, Xianbao Liu, Tao Shi, Chaoping Li, Yipeng Chen, Pan Xu, Guixiu Huang
Summary: The study presents high-quality genome sequences of two Chinese virulent strains of C. cassiicola, revealing different selective pressures and metabolic gene families between strains. Secreted protein analysis suggests a correlation between pathogenicity and quantities of secreted enzymes, with the Philippine strain encoding more enzymes than the Chinese strains. Additionally, comparative genomic analysis shows potential influences of secreted CAZymes and SMs on pathogenicity in rubber tree plantations.
Article
Microbiology
Bingxue Sun, Guangxue Zhu, Xuewen Xie, Ali Chai, Lei Li, Yanxia Shi, Baoju Li
Summary: Fungicide resistance is a serious issue in agriculture. Single mutations can evolve into double mutations under the selective pressure of SDHI, leading to higher resistance. However, double mutations suffer from fitness penalties. It is recommended to reduce the use of SDHI or use other types of fungicides to control plant diseases.
Article
Plant Sciences
C. Moore, N. Sharma, K. L. Bowen, J. Koebernick
Summary: Target spot, caused by Corynespora cassiicola, is a reemerging disease in cotton in the southeastern United States. A greenhouse protocol with optimal temperature and conducive leaf wetness duration was developed to efficiently screen cotton genotypes for resistance, allowing differentiation of genotypes with disease reactions that reflected their field rankings. The protocol will be useful for evaluating cotton breeding lines for resistance to target spot.
Article
Biochemistry & Molecular Biology
Yunyan Deng, Tao Wang, Ying Du, Lulu Zhang, Jiaxin Wang, Zhiqiu Qi, Mingshan Ji
Summary: Fludioxonil is an effective fungicide for controlling cucumber corynespora leaf spot, although there is a moderate risk of resistance. Cucumber corynespora isolates were sensitive to fludioxonil, but laboratory-created mutants showed cross-resistance to other fungicides. The resistant mutants had differences in glycerol accumulation and sensitivity to osmotic stress, as well as mutated histidine kinase genes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiamei Zhu, Jin Li, Dicheng Ma, Yangyang Gao, Jiagao Cheng, Wei Mu, Beixing Li, Feng Liu
Summary: This study reveals the variation in sensitivity of Corynespora cassiicola, the causal agent of Corynespora leaf spot, to succinate dehydrogenase inhibitors (SDHIs). Amino acid mutations in the sdhB/C/D genes of resistant strains affect the activity and binding features of SDH, resulting in multiple resistance levels and complex cross-resistance patterns to different SDHIs. This research provides a significant foundation for the development of efficient chemical control and integrated management strategies for Corynespora leaf spot.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Agronomy
L. Danilo Neves, A. Carl Bradley
Summary: The study evaluated the sensitivity of the soybean pathogens Cercospora sojina and Corynespora cassiicola to the new fungicide Pydiflumetofen. The results showed different EC50 values for these pathogens, indicating the need for monitoring their sensitivity over time.
Article
Medicine, General & Internal
Shuo Xu, Shui Lu, Yan Gu, Hongjuan Sun, Minghui Ma, Yue Leng, Wenhui Liu
Summary: This report presents a case of a 65-year-old immunosuppressed female with recurring redness and irritation in her right eye. Through ocular examination and metagenomic next-generation sequencing (mNGS), the patient was diagnosed with fungal keratitis caused by Corynespora cassiicola. Prompt and appropriate therapy led to a positive treatment outcome.
FRONTIERS IN MEDICINE
(2023)
Review
Oncology
Yahui Feng, Qian Zeng, Ying Qiu, Dongmei Li, Dongmei Shi
Summary: A farmer presented with an ulcerative skin lesion which disappeared after ALA-PDT treatment. A retrospective analysis revealed 9 cases of C. cassiicola infection with 2 deaths despite antifungal therapy.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Virology
Mingming Liu, Yunxia Ni, Hui Zhao, Xintao Liu, Min Jia, Hongyan Liu, Baoming Tian
Summary: A newly detected victorivirus, named Corynespora cassiicola victorivirus 1 (CcVV1), was found infecting Corynespora cassiicola. Its complete genome sequence includes two large ORFs encoding coat protein and RNA-dependent RNA polymerase, placing it in the genus Victorivirus. This study represents the first report of a victorivirus infecting Corynespora cassiicola with its genomic sequence identified.
ARCHIVES OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Wei-Yi Wang, Hong-Bin Luo, Jun-Qi Hu, Hui-Hua Hong
Summary: This case study is the first to report the coexistence of pulmonary Cladosporium infection and subcutaneous C. cassiicola infection in a patient with CARD9 mutation. Our findings will be helpful in enriching the phenotypic spectrum of fungal infections underlying CARD9 deficiency.
WORLD JOURNAL OF CLINICAL CASES
(2022)
