期刊
FEBS LETTERS
卷 588, 期 17, 页码 2830-2836出版社
WILEY
DOI: 10.1016/j.febslet.2014.06.035
关键词
Nucleotide-binding leucine-rich repeat containing receptor; Crohn's Disease; Caspase activation and recruitment domain; Stress kinase pathway; Innate immunity; Signal transduction
资金
- Wellcome Trust [WT085090MA]
- Medical Research Council [U117565398]
- BBSRC
- Biotechnology and Biological Sciences Research Council [979868] Funding Source: researchfish
- Medical Research Council [MC_U117565398, MC_U117533887] Funding Source: researchfish
- MRC [MC_U117533887, MC_U117565398] Funding Source: UKRI
NOD2 activation by muramyl dipeptide causes a proinflammatory immune response in which the adaptor protein CARD9 works synergistically with NOD2 to drive p38 and c-Jun N-terminal kinase (JNK) signalling. To date the nature of the interaction between NOD2 and CARD9 remains undetermined. Here we show that this interaction is not mediated by the CARDs of NOD2 and CARD9 as previously suggested, but that NOD2 possesses two interaction sites for CARD9; one in the CARD-NACHT linker and one in the NACHT itself. Structured summary of protein interactions: NOD2 physically interacts with CARD9 by anti tag coimmunoprecipitation (View interaction) (C) 2014 The Authors. Published by Elsevier B.V.
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