A high-throughput screening identifies ZNF418 as a novel regulator of the ubiquitin-proteasome system and autophagy-lysosomal pathway

The Calcineurin-TFEB-p62 Pathway Mediates the Activation of Cardiac Macroautophagy by Proteasomal Malfunction

(2020) Bo Pan et al.   CIRCULATION RESEARCH

Ube2v1 Positively Regulates Protein Aggregation by Modulating Ubiquitin Proteasome System Performance Partially Through K63 Ubiquitination

(2020) Na Xu et al.   CIRCULATION RESEARCH

Proteasome Inhibitor-Related Cardiotoxicity: Mechanisms, Diagnosis, and Management

(2020) Perry Wu et al.   Current Oncology Reports

Analysis of Contractile Function of Permeabilized Human Hypertrophic Cardiomyopathy Multicellular Heart Tissue

(2019) Nico Kresin et al.   Frontiers in Physiology

ZNF418 overexpression protects against gastric carcinoma and prompts a good prognosis

(2018) Hong-xia Hui et al.   OncoTargets and Therapy

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Zinc-finger protein 418 overexpression protects against cardiac hypertrophy and fibrosis

(2017) Liming Pan et al.   PLoS One

Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC)

(2017) Weilin Pu et al.   Clinical Epigenetics

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Proteotoxicity and Cardiac Dysfunction

(2015) P. M. McLendon et al.   CIRCULATION RESEARCH

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

PLEKHM2mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction

(2015) Emad Muhammad et al.   HUMAN MOLECULAR GENETICS

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

(2015) Mark J. Ranek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The E3 ubiquitin ligase Asb2β is downregulated in a mouse model of hypertrophic cardiomyopathy and targets desmin for proteasomal degradation

(2015) Tilo Thottakara et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

FunRich: An open access standalone functional enrichment and interaction network analysis tool

(2015) Mohashin Pathan et al.   PROTEOMICS

FHL2 expression and variants in hypertrophic cardiomyopathy

(2014) Felix W. Friedrich et al.   BASIC RESEARCH IN CARDIOLOGY

Sumo E2 Enzyme UBC9 Is Required for Efficient Protein Quality Control in Cardiomyocytes

(2014) Manish K. Gupta et al.   CIRCULATION RESEARCH

Ubiquitin-proteasome system and hereditary cardiomyopathies

(2014) Saskia Schlossarek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy

(2014) Saskia Schlossarek et al.   Frontiers in Physiology

Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis

(2013) Min-Xian Qian et al.   CELL

Protein breakdown in muscle wasting: Role of autophagy-lysosome and ubiquitin-proteasome

(2013) Marco Sandri   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice

(2012) Zongwen Tian et al.   CIRCULATION RESEARCH

Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

(2012) Thomas Cullup et al.   NATURE GENETICS

Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A/C Gene Mutation

(2012) J. C. Choi et al.   Science Translational Medicine

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Defective proteolytic systems in Mybpc3-targeted mice with cardiac hypertrophy

(2011) Saskia Schlossarek et al.   BASIC RESEARCH IN CARDIOLOGY

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

(2011) Jie Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome–associated PTPN11 mutation

(2011) Talita M. Marin et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

p97/VCP at the intersection of the autophagy and the ubiquitin proteasome system

(2010) Jeong-Sun Ju et al.   Autophagy

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

The Double-Edged Sword of Autophagy Modulation in Cancer

(2009) E. White et al.   CLINICAL CANCER RESEARCH

Autophagy: links with the proteasome

(2009) Trond Lamark et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms of cross-talk between the ubiquitin-proteasome and autophagy-lysosome systems

(2009) Viktor I. Korolchuk et al.   FEBS LETTERS

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates

(2009) Viktor I. Korolchuk et al.   MOLECULAR CELL

Targeting the ubiquitin system in cancer therapy

(2009) Daniela Hoeller et al.   NATURE