期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 43, 期 9, 页码 2240-2245出版社
WILEY-BLACKWELL
DOI: 10.1002/eji.201343800
关键词
Caspase-11; IL-1; Inflammasome; Noncanonical; Pyroptosis
类别
资金
- Singapore Immunology Network (SIgN, A*STAR)
Inflammasomes are large multiprotein platforms that mediate the processing of caspase-1, which in turn promotes the maturation and release of IL-1 and IL-18 in response to microbial and danger signals. While the canonical pathway of inflammasome activation has been known for some time, a novel mechanism of noncanonical inflammasome activation mediated by caspase-11 was more recently identified. This pathway engages caspase-11 to trigger both caspase-1-dependent and -independent production of the inflammatory cytokines IL-1, IL-18, and IL-1, as well as to promote pyroptosis, a form of genetically programmed cell death that is associated with the release of such cytokines. In this review, we gather together studies on both the mechanisms and implications of caspase-11-mediated noncanonical inflammasome activation, and discuss the emerging importance of this pathway in regulating host defense against intracellular bacterial pathogens.
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