Article
Food Science & Technology
Soghra Rabizadeh, Firouzeh Heidari, Reza Karimi, Armin Rajab, Shahram Rahimi-Dehgolan, Amirhossein Yadegar, Fatemeh Mohammadi, Hossein Mirmiranpour, Alireza Esteghamati, Manouchehr Nakhjavani
Summary: This study examined the effects of daily vitamin C supplementation on systemic oxidative stress and inflammation in patients with type 2 diabetes (T2D). The results showed that vitamin C supplementation led to a significant decrease in serum levels of malondialdehyde (MDA) and advanced glycation end products (AGEs), but had no significant impact on advanced oxidation protein products (AOPP) and oxidized low-density lipoprotein (ox-LDL). There were also no notable adverse events observed. These findings suggest that vitamin C supplementation may be beneficial in reducing AGEs and MDA in T2D patients.
FOOD SCIENCE & NUTRITION
(2023)
Article
Multidisciplinary Sciences
Laongthip Ruknarong, Chongchira Boonthongkaew, Nisa Chuangchot, Amonrat Jumnainsong, Naruemon Leelayuwat, Apinya Jusakul, Silvana Gaudieri, Chanvit Leelayuwat
Summary: The study found that vitamin C supplementation can alter the expression of circulating miR-451a in patients with T2DM, potentially serving as a biomarker for oxidative status and poor glycemic control, and leading to a novel molecular strategy to reduce oxidative stress in these patients.
Article
Food Science & Technology
Amir Hosein Moslehi, Fatemeh Hoseinpour, Amir Saber, Maryam Akhavan Taheri, Amir Hossein Hashemian
Summary: This study aimed to investigate the effects of Inositol and vitamin C on cisplatin-induced infertility. The results showed that Inositol and vitamin C improved the histopathological damage in the uterus and ovaries caused by cisplatin, increased progesterone and estradiol levels, and reduced apoptosis by regulating related gene levels. Furthermore, they alleviated oxidative stress in the uterus and ovaries. These findings suggest that Inositol and vitamin C protect against cisplatin-related infertility.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Immunology
Ebin Johny, Aishwarya Jala, Bishamber Nath, Md Jahangir Alam, Indra Kuladhipati, Rupam Das, Roshan M. Borkar, Ramu Adela
Summary: Vitamin D supplementation may help reduce or prevent disease progression and cardiovascular risk in type 2 diabetes patients by suppressing oxidative stress and platelet-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mohamed A. Hashem, Sahar S. Abd El Hamied, Eman M. A. Ahmed, Shimaa A. Amer, Aziza M. Hassan
Summary: The study evaluated the efficacy of vitamin C and vitamin E in mitigating oxidative stress, hematobiochemical, and histopathological changes in the kidney induced by copper sulfate (CuSO4) toxicity in broiler chickens. The findings showed the possible preventive and alleviating impacts of dietary antioxidants on hematobiochemical alterations, oxidative stress, and kidney damage induced by CuSO4 toxicity.
Article
Pharmacology & Pharmacy
Samia Omar, Radwa Maher El Borolossy, Tamer Elsaid, Nagwa A. Sabri
Summary: The combination of rutin and vitamin C has shown significant improvement in oxidative stress and inflammation in hemodialysis patients, reducing symptoms and risks.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Teodora-Irina Adam-Bonci, Eduard-Alexandru Bonci, Alina-Elena Parvu, Andrei-Ioan Herdean, Augustin Mot, Marian Taulescu, Andrei Ungur, Raluca-Maria Pop, Corina Bocsan, Alexandru Irimie
Summary: The study showed that oral vitamin D supplementation can reduce oxidative forces and increase antioxidant capacity, while also exhibiting anti-inflammatory effects to protect against acute airway inflammation related to oxidative stress processes induced by ovalbumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Liyun Wu, Wenjie Xu, Hongyan Li, Bo Dong, Hancheng Geng, Junyan Jin, Dong Han, Haokun Liu, Xiaoming Zhu, Yunxia Yang, Shouqi Xie
Summary: Previous studies have shown that vitamin C has a protective effect in fish. In this study, it was found that vitamin C can attenuate oxidative damage, inflammation, and acute hypoxia-induced apoptosis in gibel carp. This protective mechanism is mediated through the activation of the Nrf2/Keap1 signaling pathway. These findings provide new insights into the defense strategies of fish under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Xiao-Qing Li, Yi Wang, Shu-Jie Yang, Yu Liu, Xiang Ma, Lu Liu, Si-Hong Li, Dong Niu, Xing Duan
Summary: Maternal diabetes has negative effects on oocyte quality, but melatonin supplementation can protect oocytes from these damages and improve oocyte quality in assisted reproductive technologies.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Physiology
Nikos V. Margaritelis, George G. Nastos, Olga Vasileiadou, Panagiotis N. Chatzinikolaou, Anastasios A. Theodorou, Vassilis Paschalis, Ioannis S. Vrabas, Antonios Kyparos, Ioannis G. Fatouros, Michalis G. Nikolaidis
Summary: The study aimed to investigate the variability in redox and physiological responses of antioxidant-deficient subjects after antioxidant supplementation. A low vitamin C group and a control group were compared, and the low vitamin C group showed lower vitamin C levels, higher F-2-isoprostanes levels, impaired VO2max, and lower isometric peak torque. Antioxidant supplementation resulted in significant changes in vitamin C levels, F-2-isoprostanes levels, VO2max, and isometric peak torque. Individual responses varied significantly, indicating the need for personalized nutritional interventions in exercise physiology.
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Article
Biochemistry & Molecular Biology
S. Hameed Kadar Ali, K. Wasim Ali Raja, N. Irfan, Mohammad Habeeb, Y. Ismail
Summary: This study found that supplementation with alpha lipoic acid and vitamin C can effectively reduce oxidative stress induced by acute amitriptyline poisoning, showing a certain therapeutic effect.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Olamide Adebiyi, Kabirat Adigun, Praise David-Odewumi, Uthman Akindele, Funsho Olayemi
Summary: The study investigated the neuroprotective effects of gallic and ascorbic acids in CdCl2-induced neurotoxicity. The results showed that gallic and ascorbic acids can enhance learning and memory, decrease anxiety and depressive-like behavior, and protect myelin in CdCl2-induced neurotoxicity.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Milena Cojic, Radivoj Kocic, Aleksandra Klisic, Gordana Kocic
Summary: The study suggests that daily oral doses of vitamin D can improve HbA1c levels over a period of 3 and 6 months, with a significant decrease in advanced oxidation protein products levels after 3 months of higher vitamin D doses. However, the impact of vitamin D on the HOMA-IR index, malondialdehyde levels, and TG/TBARS index was not statistically significant. Further research should focus on determining the appropriate doses of vitamin D in patients with type 2 diabetes to mitigate oxidative stress risk, metabolic syndrome risk, and related cardiovascular events.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Elham Moslemi, Vali Musazadeh, Zeynab Kavyani, Navid Naghsh, Seyyed Morteza Seyyed Shoura, Parvin Dehghan
Summary: This umbrella meta-analysis summarized existing systematic reviews and meta-analyses of clinical trials on vitamin D supplementation. The findings revealed that vitamin D supplementation significantly reduced serum levels of CRP, TNF-alpha, and MDA, but did not show significant changes in IL-6, TAC, and GSH. Vitamin D could be considered as an adjuvant therapy for relieving inflammation and oxidative stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Silvana G. P. Campos, Bianca F. Goncalves, Thalles Fernando Rocha Ruiz, Ellen Cristina R. Leonel, Daniele L. Ribeiro, Luiz Roberto Falleiros Junior, Rejane M. Goes, Sebastiao R. Taboga
Summary: This study evaluated changes in proteoglycan morphology and composition in the prostatic stroma of castrated gerbils. Results showed an increase in chondroitin sulfate frequency after androgen blockade and an increase in perlecan content. The length and shape of proteoglycans were also altered. These findings suggest that proteoglycans might respond to androgen deprivation independently of androgenic regulation.
Article
Developmental Biology
Tatiane Pereira Scarpelli, Eloisa Zanin Pytlowanciv, Maria Etelvina Pinto-Fochi, Sebastiao Roberto Taboga, Rejane Maira Goes
Summary: Maternal obesity and high-fat diet during breastfeeding lead to stromal hyperplasia and diffuse acinar atrophy in the aging rat prostate, which is closely related to dyslipidemia and reduced testosterone levels. The high-lipid nutritional environment from intrauterine and throughout life facilitates the development of prostatic intraepithelial neoplasia and worsens degenerative changes in the gland.
Article
Zoology
Priscila L. R. Dourado, Daina Lima, Jaco J. Mattos, Afonso C. D. Bainy, Suelen C. Grott, Thiago C. Alves, Eduardo Alves de Almeida, Danilo G. Humberto da Silva
Summary: This study investigates the effects of the insecticide fipronil on the GABAergic responses of the Nile Tilapia to hypoxia. The results show that hypoxia has opposite effects on the gene transcription of ionotropic and metabotropic GABA receptors, while fipronil impairs the brain GABAergic signaling of hypoxia-tolerant fish during the transition from normoxia to acute hypoxia.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Anatomy & Morphology
Pollyana B. Pimentel, Juliana Filgueira Ferraz, Cornelio Souza Santigo, Emilia Miguel Soares, Eliana Morielle-Versute, Sebastiao R. Taboga, Carolina C. Souza, Mateus R. Beguelini
Summary: Despite being highly diverse and widely distributed, the reproductive accessory glands (RAGs) of bats have received limited attention in research. This study aimed to analyze and compare the composition, anatomy, and histology of male RAGs in three cosmopolitan bat families (Vespertilionidae, Molossidae, and Emballonuridae). The results revealed that the RAGs of these bat species consist of an intra-abdominal prostatic complex, urethral glands, and inguinal bulbourethral glands, but lack ampullary glands or seminal vesicles. The prostatic complex varies in the number of regions and lobed structure among the species.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Cell Biology
Liana Silva Gomes, Danilo da Silva Lima, Janaina Ribeiro Costa, Jane Sousa Naves, Mara Rubia Marques, Sebastiao Roberto Taboga, Paulo Cesar Ghedini, Manoel Francisco Biancardi, Fernanda Cristina Alcantara dos Santos
Summary: This study evaluated the effects of aluminum neonatal exposure on the male and female gerbil prostates. Results showed that adult male prostates exhibited moderate hyperplasia and increased cell proliferation, while senile males showed intense hyperplasia. Additionally, there was a reduction in prostate secretory function at both ages. Female prostates exhibited similar morphological changes to males, with adult females showing a lower regulation of androgen receptor and estrogen receptor alpha, and senile females showing intense hyperplastic growth with an increase in estrogen receptor alpha and a reduction in stromal androgen receptor.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Ecology
David Sanchez-Domene, Fernando R. da Silva, Diogo B. Provete, Alba Navarro-Lozano, Raphael D. Acayaba, Cassiana C. Montagner, Denise de C. Rossa-Feres, German M. Lopez-Iborra, Eduardo A. Almeida
Summary: Global demand for crops will increase in the future, contributing to the expansion of arable land and loss of natural habitats. This study in Brazil examined the impact of agrochemicals and landscape changes on tropical freshwater biodiversity. The findings suggest that certain frog species are negatively affected by high concentrations of agrochemicals in sugarcane-dominated agroecosystems, highlighting the importance of conserving ponds near forests and reducing agrochemical runoffs.
ECOLOGICAL APPLICATIONS
(2023)
Editorial Material
Environmental Sciences
Eduardo Alves de Almeida, Afonso Celso Dias Bainy, Lucia Guilhermino
Article
Environmental Sciences
Suelen Cristina Grott, Nicole Grasmuk Israel, Daina Lima, Camila Lisarb Velasquez Bastolla, Francisco Carneiro, Thiago Caique Alves, Daiane Bitschinski, Afonso Celso Dias Bainy, Elizia Barbosa da Silva, Claudia Almeida Coelho de Albuquerque, Eduardo Alves de Almeida
Summary: This study evaluated the influence of different temperatures and exposure to the herbicide ametryn on the thyroidogenesis of bullfrog tadpoles. Results showed that higher temperature and ametryn exposure caused a delay in tadpole development and decreased the area and number of follicles in the thyroid gland. Transcript levels of thyroid hormone receptors and iodothyronine deiodinase 3 were lower at higher temperatures, indicating a developmental delay. Tadpoles exposed to high levels of ametryn also exhibited delayed development and lower transcript levels, possibly related to lower levels of estradiol.
ENVIRONMENTAL POLLUTION
(2023)
Article
Food Science & Technology
Priscila Aparecida Horn, Ana Lucia Bertarello Zeni, Natalia Cavichioli, Evelyn Winter, Keila Zaniboni Siqueira Batista, Luciano Vitali, Eduardo Alves de Almeida
Summary: This study characterized the chemical composition of brewer's spent yeast (BSY) from two different beer productions and tested its cytotoxicity in various cell lineages. The results showed that BSY samples had similar lipid and ash content but slight differences in other nutritional components. BSY2 sample had higher concentrations of glucans and phenolic compounds. Both BSY1 and BSY2 extracts demonstrated similar antioxidant capacity and were not cytotoxic to most cell lines except PANC-1 cells. These findings suggest that brewery residue can be a value-added functional food with potential adjuvant role against PANC-1 cell lines.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Cell Biology
Thalles F. R. Ruiz, Vitor Grigio, Luara J. Ferrato, Lorena G. de Souza, Simone J. Colleta, Gustavo M. Amaro, Rejane M. Goes, Patricia S. L. Vilamaior, Ellen C. R. Leonel, Sebastia O. R. Taboga
Summary: This study demonstrates that exposure of pregnant and lactating women to the endocrine disruptor bisphenol A (BPA) can impact their ovarian function and accelerate aging of the ovaries. Ovaries exposed to BPA showed impaired follicle development and disruption in hormone signaling. BPA exposure also affected steroidogenesis, leading to decreased levels of estrogen and testosterone. These changes play a significant role in follicular development and contribute to perimenopausal and infertile features.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Lilian Nogueira, Danielly Garcia, Fernando Sanzi Cortez, Camilo Dias Seabra Pereira, Eduardo Alves de Almeida
Summary: This study assessed the combined effect of hypoxia and diesel exposure on biochemical parameters of Perna perna mussels. The results showed that cycles of air exposure and reoxygenation caused oxidative stress and antioxidant modulation in both the gills and digestive glands. The presence of diesel in water apparently enhanced the mussels' capacity to avoid lipid peroxidation under hypoxia and reoxygenation stress.
MARINE POLLUTION BULLETIN
(2023)
Article
Biotechnology & Applied Microbiology
Bruna Maria Salotti de Souza, Luiz Henrique Alves Guerra, Giovanna Rossi Varallo, Sebastiao Roberto Taboga, Ana Lucia Barretto Penna
Summary: This study evaluated the effects of consuming milk fermented by Lacticaseibacillus (Lc.) casei SJRP38 and Limosilactobacillus (Lm.) fermentum SJRP43 on bacterial translocation, stool analysis, and intestinal morphology in healthy BALB/c mice. The results showed that fermented milk containing these strains promoted a healthier microbiota and improved the intestinal condition.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Environmental Sciences
Tays Daiane Izidoro, Suelen Cristina Grott, Bruno Busnello Kubiak, Thales Renato Ochotorena de Freitas, Thiago Caique Alves, Eduardo Alves Almeida, Daniel Galiano
Summary: Rampant urbanization in coastal areas impacts the health of the tuco-tuco Ctenomys flamarioni. This study found that individuals in the impacted area had higher levels of oxidative damage and lower antioxidant activity, indicating the negative effect of anthropogenic activities on the oxidative status of animals in this environment. The findings can be used as a reference for future studies on tuco-tucos.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)