Article
Medicine, General & Internal
Mohammad Reza Nazem, Mojgan Asadi, Maryam Adelipour, Niloofar Jabbari, Abdolamir Allameh
Summary: This study evaluated the effects of zinc supplementation on oxidative status and glycaemic parameters in overweight patients with type 2 diabetes mellitus (T2DM). The results showed that zinc supplementation for 8 weeks significantly improved the oxidative balance and controlled the glycaemic indices in these patients.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Immunology
Ebin Johny, Aishwarya Jala, Bishamber Nath, Md Jahangir Alam, Indra Kuladhipati, Rupam Das, Roshan M. Borkar, Ramu Adela
Summary: Vitamin D supplementation may help reduce or prevent disease progression and cardiovascular risk in type 2 diabetes patients by suppressing oxidative stress and platelet-mediated inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Nutrition & Dietetics
Xiaomin Sun, Tao Yan, Zhongying Li, Sirui Zhou, Wen Peng, Wei Cui, Jing Xu, Zhen-Bo Cao, Lin Shi, Youfa Wang
Summary: This study investigated the effects of a 12-week exercise intervention with or without vitamin D supplementation on insulin resistance and the plasma lipidome of participants with type 2 diabetes. The interventions did not improve insulin resistance but led to changes in the plasma lipidome. Baseline plasma lipid levels could predict an individual's response to intervention.
Review
Nutrition & Dietetics
Agata Pienkowska, Justyna Janicka, Michal Duda, Karena Dzwonnik, Kamila Lip, Aleksandra Medza, Agnieszka Szlagatys-Sidorkiewicz, Michal Brzezinski
Summary: This study aimed to evaluate the potential benefits of vitamin D supplementation in preventing diabetes and found that it does not reduce insulin resistance or the risk of developing type 2 diabetes in prediabetes. Due to the variation in study designs and biases, clear interpretation of the results is not possible, and long-term and well-designed studies are still required.
Review
Nutrition & Dietetics
Clive J. Petry
Summary: Iron supplementation in pregnancy may increase the risk of gestational diabetes, particularly in women who are already iron-replete. However, current evidence on this topic is contradictory, and the magnitude of any increased risk appears relatively small, urging caution in interpreting the results.
Review
Nutrition & Dietetics
Xinrui Yi, Mosi Dong, Naifei Guo, Jinlong Tian, Ping Lei, Song Wang, Yufeng Yang, Yan Shi
Summary: The prevalence of T2DM is increasing annually. Medications for T2DM have adverse effects, therefore, researchers have discovered the potential benefits of natural products, specifically flavonoids, in improving T2DM and its complications. Flavonoids possess various biological activities like organ protection, hypoglycemic, lipid-lowering, anti-oxidative, and anti-inflammatory effects. They ameliorate T2DM through anti-oxidation, anti-inflammatory action, glucose and lipid metabolism regulation, and insulin resistance management. This review aims to demonstrate the potential benefits of flavonoids in T2DM and pave the way for the development of novel hypoglycemic medications.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Reem S. Alruhaimi, Gomaa Mostafa-Hedeab, Maisa Siddiq Abduh, Albandari Bin-Ammar, Emad H. M. Hassanein, Emadeldin M. Kamel, Ayman M. Mahmoud
Summary: This study found that Euphorbia peplus extract (EPE) has anti-diabetic effects in rats with type 2 diabetes, improving hyperglycemia, insulin resistance, dyslipidemia, inflammation, and oxidative stress, and increasing antioxidant capacity.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Jamil Said, David Lagat, Allan Kimaina, Chrispine Oduor
Summary: The study examined the relationship between serum vitamin D, insulin resistance, and beta cell function in a subpopulation of black Kenyan T2DM patients, and found that 74.1% of patients had vitamin D deficiency, which was positively correlated with beta cell function. The results indicate that beta cell dysfunction is more prominent than insulin resistance in this population.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Teodora-Irina Adam-Bonci, Eduard-Alexandru Bonci, Alina-Elena Parvu, Andrei-Ioan Herdean, Augustin Mot, Marian Taulescu, Andrei Ungur, Raluca-Maria Pop, Corina Bocsan, Alexandru Irimie
Summary: The study showed that oral vitamin D supplementation can reduce oxidative forces and increase antioxidant capacity, while also exhibiting anti-inflammatory effects to protect against acute airway inflammation related to oxidative stress processes induced by ovalbumin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Francesca Gorini, Cristina Vassalle
Summary: Type 2 diabetes is a major global public-health concern, affecting over 400 million people worldwide. Selenium has recently been identified as a determinant of T2D pathogenesis and progression, playing a crucial role in antioxidant response, thyroid hormone regulation, and glucose metabolism.
Review
Biochemistry & Molecular Biology
Stephanie N. Alu, Evan A. Los, George A. Ford, William L. Stone
Summary: Considerable evidence supports the role of oxidative stress in adult type 2 diabetes (T2D), and this will also affect more and more children. Understanding the factors contributing to oxidative stress and T2D risk may help develop optimal early intervention strategies. The combination of systems medicine and redoxomics holds promise in optimizing future healthcare strategies for T2D patients.
Article
Nutrition & Dietetics
Qunyan Xiang, Hui Xu, Junkun Zhan, Shuzhen Lu, Shuang Li, Yanjiao Wang, Yi Wang, Jieyu He, Yuqing Ni, Linsen Li, Yiyang Liu, Youshuo Liu
Summary: This study aimed to explore the association between insulin resistance (IR) and vitamin D deficiency (VDD). A negative correlation between the triglyceride-glucose (TyG) index and vitamin D level was found in patients with type 2 diabetes mellitus (T2DM). After adjusting for clinical and laboratory parameters, it was revealed that patients with higher TyG index had an increased risk of VDD in the T2DM population.
Article
Biochemistry & Molecular Biology
Zhiyong Hu, Xueyuan Zhi, Jiafu Li, Bingyan Li, Jinxiu Wang, Jianliang Zhu, Zengli Zhang
Summary: This randomized controlled trial found that long-term vitamin D supplementation significantly reduced fasting insulin, HOMA-IR, and serum concentrations of non-HDL-C, hs-CRP, and uric acid among middle-aged to elderly patients with type 2 diabetes (T2D). Vitamin D status, gender, and baseline obesity may modify the effects of vitamin D supplementation.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Thanh Tung Tran Huu, Huu Dang Tran, Thua Nguyen Tran, Bui Bao Hoang
Summary: The study aimed to clarify the prevalence of vitamin D deficiency in diabetic patients in Hue City, Vietnam and its relationship with insulin resistance and blood sugar levels. The results showed that patients with better glucose-related parameters tended to have a better vitamin D status. Factors such as exercise level and sex were found to be related to vitamin D status.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Josephine Yu, Preeti Sharma, Christian M. Girgis, Jenny E. Gunton
Summary: The prevalence of type 1 diabetes is rising steadily and vitamin D may contribute to this increase. This systematic review examined studies on vitamin D and type 1 diabetes, finding strong associations between low vitamin D levels and type 1 diabetes. Animal studies and human trials also suggest that vitamin D treatment or supplementation can be beneficial in reducing the risk of type 1 diabetes. Maintaining optimal circulating 25-hydroxyvitamin D levels may help to prevent or delay the development of type 1 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jasmina Brboric, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Giovanna Delogu, Darinka Gjorgieva Ackova, Kristina Kostic, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Luciano Saso
Summary: The aim of this study was to identify representatives of natural and natural-like phenol monomers and their C2-symmetric dimers with the strongest antioxidant activity and the lowest prooxidant activity. The results showed that dehydrozingerone derivatives (compounds 6 and 12) exhibited the highest antioxidant activity and could be potential precursors for the synthesis of novel polyphenolic molecules with therapeutic applications.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Aleksandra Vukasinovic, Barbara Ostanek, Aleksandra Klisic, Srdjan Kafedzic, Marija Zdravkovic, Ivan Ilic, Miron Sopic, Sasa Hinic, Milica Stefanovic, Lidija Memon, Branka Gakovic, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, Janja Marc, Aleksandar N. Neskovic, Jelena Kotur-Stevuljevic
Summary: There is an association between leukocyte telomere length, telomerase activity, coronary artery disease (CAD) and oxidative stress. Telomerase activity and telomere length are higher in thromboaspirates compared to peripheral blood leukocytes, and they have diagnostic ability to differentiate patients with ST-segment elevation myocardial infarction (STEMI) from healthy individuals.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Cell Biology
Petar Vukicevic, Aleksandra Klisic, Vojislava Neskovic, Luka Babic, Aleksandar Mikic, Natasa Bogavac-Stanojevic, Milos Matkovic, Vladimir Milicevic, Nemanja Aleksic, Jelena Kotur-Stevuljevic
Summary: The study aimed to investigate the changes in oxidative stress status during coronary artery bypass grafting surgeries, showing variations in oxidative stress parameters based on different surgical procedures and patient conditions.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Multidisciplinary Sciences
Aleksandra Klisic, Nebojsa Kavaric, Ana Ninic, Jelena Kotur-Stevuljevic
Summary: The study revealed a significant association between oxidative stress, cardiometabolic biomarkers, and NAFLD. Principal component analysis identified three key factors affecting NAFLD status: oxidative stress-cardiometabolic, pro-oxidants, and antioxidants.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Irena Radoman Vujacic, Jelena Kostadinovic, Ana Ninic
Summary: This study examined the relationship between metabolic and renal biomarkers and vitamin D in postmenopausal women. The results showed that the joint involvement of renal function biomarkers and metabolic syndrome-related features can differentiate postmenopausal women with lower vitamin D levels.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Aleksandra Klisic, Jelena Kotur-Stevuljevic, Ana Ninic
Summary: This study examined the relationship between serum endocan level and UKPDS risk engine score in type 2 diabetes patients. The results showed that endocan is an independent predictor for moderate and high estimated risks of cardiovascular disease in these patients.
METABOLIC SYNDROME AND RELATED DISORDERS
(2023)
Article
Pediatrics
Ljiljana Bjelakovic, Lazar Stosic, Aleksandra Klisic, Marko Jovic, Sanja Stankovic, Aleksandra Stankovic, Sasa Pantelic, Danijela Zivkovic, Vladimir Vukovic, Bojko Bjelakovic
Summary: This study investigated the awareness and knowledge of familial hypercholesterolemia (FH) among pediatricians in Serbia. The results showed that although most pediatricians had knowledge about the genetic inheritance and long-term health risks of FH, there was a substantial lack of practical clinical knowledge, and a low awareness of international guidelines for FH drug treatment.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Klisic, Dimitrios Patoulias
Summary: Discovered twenty years ago, endocan is still an intriguing biomarker associated with inflammation. It is a soluble dermatan sulphate proteoglycan secreted by endothelial cells and expressed in tissues related to enhanced proliferation. Endocan has been extensively studied in various cardiometabolic disorders, such as type 2 diabetes, hypertension, atherosclerosis, kidney disease, obesity, polycystic ovary syndrome, metabolic syndrome, and fatty liver disease. Understanding the role of endocan in these disorders is important for developing potential therapeutic strategies to delay or prevent related complications.
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Milena Cojic, Dimitrios Patoulias, Ana Ninic
Summary: This study examined the potential relationship between 25-hydroxyvitamin D [25(OH)D] and type 2 diabetes (T2D) in postmenopausal women in Montenegro. It found that the relationship between [25(OH)D] and T2D is influenced by central obesity and inflammation in these women. Additionally, the study suggested that a set of biomarkers may provide better information for assessing the risk of T2D in postmenopausal women, rather than using [25(OH)D] alone.
Article
Medicine, General & Internal
Mirjana Bakic, Aleksandra Klisic, Vesna Karanikolic
Summary: The study revealed higher levels of NLR and IL-22 in patients with atopic dermatitis (AD) over the age of 50, and a higher inflammatory state in both psoriasis (PsO) and AD patients with comorbidities as reflected by certain platelet indexes.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, General & Internal
Aleksandra Klisic, Irena Radoman Vujacic, Jelena Munjas, Ana Ninic, Jelena Kotur-Stevuljevic
Summary: With the rapid increase in obesity and type 2 diabetes mellitus (T2D) worldwide, cardiovascular diseases have become the leading cause of death in these patients. Oxidative stress and inflammation have been identified as underlying mechanisms related to the occurrence and progression of T2D. Micro-ribonucleic acids (miRNAs) are considered as new genetic biomarkers, playing an important role in investigating various metabolic pathways of insulin signaling.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
A. Klisic, A. Scepanovic, J. Kotur-Stevuljevic, A. Ninic
Summary: This study aimed to investigate the association between some novel indexes and glycated hemoglobin (HbA1c) in patients with prediabetes and T2D.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
M. Roksandic Milenkovic, A. Klisic, V Ceriman, J. Kotur Stevuljevic, K. Savic Vujovic, D. Mirkov, M. Gajic, B. Ilic, N. Dimic, N. Samardzic, D. Jovanovic
Summary: This study analyzed oxidative stress parameters, inflammation markers, and vitamin D levels in patients with idiopathic pulmonary fibrosis (IPF). The results showed that IPF patients have severe oxidative stress and inflammation. Additionally, sPD-L1 may play a significant role in the immune response in IPF.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
A. Klisic, I. Radoman Vujacic, L. J. Vuckovic, A. Ninic
Summary: The study found that total and differential white blood cell counts were higher in late adolescents with moderate/high cardiovascular risk. Multivariate binary regression analysis showed that total white blood cell count independently increased cardiovascular risk score by 1.623 times. Neutrophil and eosinophil counts were also independently able to increase cardiovascular risk score by 1.486 and 1.556 times, respectively.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)