MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

(2011) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Structures of human MST3 kinase in complex with adenine, ADP and Mn2+

(2010) Tzu-Ping Ko et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the WNK-activated SPAK kinase in regulating blood pressure

(2010) Fatema H. Rafiqi et al.   EMBO Molecular Medicine

Fission Yeast Germinal Center (GC) Kinase Ppk11 Interacts with Pmo25 and Plays an Auxiliary Role in Concert with the Morphogenesis Orb6 Network (MOR) in Cell Morphogenesis

(2010) Tetsuya Goshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-451 Regulates LKB1/AMPK Signaling and Allows Adaptation to Metabolic Stress in Glioma Cells

(2010) Jakub Godlewski et al.   MOLECULAR CELL

Structural Comparison of Human Mammalian Ste20-Like Kinases

(2010) Christopher J. Record et al.   PLoS One

New Roles for the LKB1-NUAK Pathway in Controlling Myosin Phosphatase Complexes and Cell Adhesion

(2010) A. Zagorska et al.   Science Signaling

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

(2009) Charles Simon Bond et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex

(2009) Jean Paul ten Klooster et al.   DEVELOPMENTAL CELL

Crystal structure of domain-swapped STE20 OSR1 kinase domain

(2009) Seung-Jae Lee et al.   PROTEIN SCIENCE

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

(2009) E. Zeqiraj et al.   SCIENCE

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

(2009) Elton Zeqiraj et al.   PLOS BIOLOGY

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

(2008) J. Ponce-Coria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the OSR1 kinase, a hypertension drug target

(2008) Fabrizio Villa et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

SNF1/AMPK pathways in yeast

(2007) Kristina Hedbacker   Frontiers in Bioscience-Landmark