The Perforin Pore Facilitates the Delivery of Cationic Cargos

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

(2013) J. A. Lopez et al.   BLOOD

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

(2013) J. A. Lopez et al.   JOURNAL OF IMMUNOLOGY

Effects of MACPF/CDC proteins on lipid membranes

(2012) Robert J. C. Gilbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

(2012) David B. Thompson et al.   CHEMISTRY & BIOLOGY

Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins

(2012) Michelle A Dunstone et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ratcheting up protein translocation with anthrax toxin

(2012) Geoffrey K. Feld et al.   PROTEIN SCIENCE

Intercellular communication via the endo-lysosomal system: Translocation of granzymes through membrane barriers

(2011) Sarah E. Stewart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mouse granzyme K has pro-inflammatory potential

(2011) L T Joeckel et al.   CELL DEATH AND DIFFERENTIATION

Cytochrome c: the Achilles’ heel in apoptosis

(2011) A. V. Kulikov et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Granulysin Delivered by Cytotoxic Cells Damages Endoplasmic Reticulum and Activates Caspase-7 in Target Cells

(2011) R. V. Saini et al.   JOURNAL OF IMMUNOLOGY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

Perforin Rapidly Induces Plasma Membrane Phospholipid Flip-Flop

(2011) Sunil S. Metkar et al.   PLoS One

Human Perforin Employs Different Avenues to Damage Membranes

(2010) Tilen Praper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

(2009) J. Thiery et al.   BLOOD

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Comparing the intracellular mobility of fluorescent proteins following in vitro expression or cell loading with streptolysin-O

(2008) Jianrong Wu et al.   JOURNAL OF BIOMEDICAL OPTICS

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules

(2008) Vivien R. Sutton et al.   METHODS