p87 and p101 Subunits Are Distinct Regulators Determining Class IBPhosphoinositide 3-Kinase (PI3K) Specificity

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

(2013) Romy Walser et al.   PLOS BIOLOGY

PI3K signalling: the path to discovery and understanding

(2012) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G Protein-Coupled Receptor-Mediated Activation of p110  by G   Is Required for Cellular Transformation and Invasiveness

(2012) H. A. Dbouk et al.   Science Signaling

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

(2011) Aliaksei Shymanets et al.   BIOCHEMICAL JOURNAL

Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression

(2011) Michael C. Schmid et al.   CANCER CELL

The catalytic phosphoinositol 3-kinase isoform p110δ is required for glioma cell migration and invasion

(2011) Sze Ki Luk et al.   EUROPEAN JOURNAL OF CANCER

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

(2011) Xuxiao Zhang et al.   MOLECULAR CELL

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Differential roles for the p101 and p84 regulatory subunits of PI3Kγ in tumor growth and metastasis

(2011) J A Brazzatti et al.   ONCOGENE

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling

PI3K kinase and scaffold functions in heart

(2010) Federico Damilano et al.   Annals of the New York Academy of Sciences

Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS

(2010) Li Zhao et al.   CELL CYCLE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A biochemical mechanism for the oncogenic potential of the p110  catalytic subunit of phosphoinositide 3-kinase

(2010) H. A. Dbouk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Form and flexibility in phosphoinositide 3-kinases

(2009) Roger Williams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Fine tuning the immune response with PI3K

(2009) David A. Fruman et al.   IMMUNOLOGICAL REVIEWS

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110 

(2009) B. Kurig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gβγ-Copurified Lipid Kinase Impurity from Sf9 Cells

(2009) Aliaksei Shymanets et al.   PROTEIN AND PEPTIDE LETTERS

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling

Pasteurella multocida toxin activates Gβγ dimers of heterotrimeric G proteins

(2008) Inga Preuß et al.   CELLULAR SIGNALLING

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide 3-Kinase p110  Activity: Key Role in Metabolism and Mammary Gland Cancer but Not Development

(2008) E. Ciraolo et al.   Science Signaling