PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110  but Not p110  Promotes Optimal Allergic Responses In Vivo

(2014) K. Ali et al.   JOURNAL OF IMMUNOLOGY

p85  regulatory subunit of class IA PI3 kinase negatively regulates mast cell growth, maturation, and leukemogenesis

(2012) S. Krishnan et al.   BLOOD

GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

(2012) Sabine Suire et al.   EMBO JOURNAL

Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110  (PIK3CA)

(2012) J. E. Burke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ

(2011) Aliaksei Shymanets et al.   BIOCHEMICAL JOURNAL

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

(2011) Xuxiao Zhang et al.   MOLECULAR CELL

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases

(2011) W-C Hon et al.   ONCOGENE

Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

(2011) N. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K  within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

(2011) B. Becattini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85  Src homology-2 domains

(2011) J. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

(2011) Oscar Vadas et al.   Science Signaling

Dynamics of the Phosphoinositide 3-Kinase p110δ Interaction with p85α and Membranes Reveals Aspects of Regulation Distinct from p110α

(2011) John E. Burke et al.   STRUCTURE

PI3Kγ Differentially Regulates FcεRI-Mediated Degranulation and Migration of Mast Cells by and toward Antigen

(2009) Daisuke Endo et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110 

(2009) B. Kurig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K  Adaptor Subunits Define Coupling to Degranulation and Cell Motility by Distinct PtdIns(3,4,5)P3 Pools in Mast Cells

(2009) T. Bohnacker et al.   Science Signaling

Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

(2008) Jeffrey D. Carson et al.   BIOCHEMICAL JOURNAL