Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Esther Llorens-Alvarez, Jordi Alom, Teodoro del Ser, Jesus Avila, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: This study demonstrates that P-tau can modulate AChE expression, and suggests that AChE may increase in the initial phases of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Cell Biology
Lingjuan Wang, Sijin Ouyang, Bin Li, Hao Wu, Fengli Wang
Summary: Ferroptosis is a newly characterized form of non-apoptotic-programmed cell death that has implications in human diseases and potential therapeutic applications for cancer. GSK-3 beta acts as a positive modulator of ferroptosis by influencing cellular iron metabolism, indicating its potential as a target for cancer chemotherapy.
CELL DEATH DISCOVERY
(2021)
Article
Multidisciplinary Sciences
Samuel M. Law, Jie J. Zheng
Summary: Wnt signaling pathways play a significant role in various diseases. β-catenin is central to the canonical Wnt signaling pathway. CHIR-99021, a GSK-3β inhibitor, is widely used for studying this pathway. However, caution is needed when using CHIR-99021 at certain concentrations.
Article
Multidisciplinary Sciences
Lynette Steele, Aarren J. Mannion, Gary Shaw, Kenneth A. Maclennan, Graham P. Cook, Christopher E. Rudd, Alison Taylor
Summary: GSK-3 plays a crucial role in T cell function and tumor immunity, with the isoforms GSK-3α and GSK-3β having differential effects on immune responses and tumor infiltration, working together to control PD-1 expression and tumor growth.
Article
Chemistry, Medicinal
Xueyang Jiang, Junting Zhou, Yang Wang, Xin Liu, Kaiying Xu, Jian Xu, Feng Feng, Haopeng Sun
Summary: A series of heterobifunctional small molecule PROTACs based on CRBN were designed and synthesized to effectively degrade GSK-3β protein and protect against cell death, showing potential for further investigation in the biological function of GSK-3β protein and its association with diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Immunology
Ricarda Cortes-Vieyra, Octavio Silva-Garcia, Anel Gomez-Garcia, Sergio Gutierrez-Castellanos, Cleto Alvarez-Aguilar, Victor M. Baizabal-Aguirre
Summary: Understanding the regulation of GSK3 beta activity in inflammatory responses caused by pathogenic microorganisms is crucial for controlling the intensity of inflammation. Recent studies have shown that regulating GSK3 beta activity can reduce the detrimental effects of the inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Matthew P. Davies, Rocio Benitez, Concepcion Perez, Sven Jakupovic, Philip Welsby, Klaudia Rzepecka, Jane Alder, Colin Davidson, Ana Martinez, Joseph M. Hayes
Summary: The study introduces the in silico design, screening, and in vitro validation of potent GSK-3 beta type-II inhibitors, leading to the identification of highly potent nanomolar inhibitors with potential neuroprotective effects. The designed inhibitors show promise as a potential route toward more clinically effective GSK-3 beta inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Summary: The combination of GSK3 inhibitors and PARP inhibitors shows a strong synergistic effect in colorectal cancer cells, enhancing cell sensitivity to treatment and improving therapeutic outcomes.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Chenggang Zhao, Huihan Yu, Xiaoqing Fan, Wanxiang Niu, Junqi Fan, Suling Sun, Meiting Gong, Bing Zhao, Zhiyou Fang, Xueran Chen
Summary: This study revealed the role of GSK3β in temozolomide resistance in GBM, showing that palmitoylation mediated by ZDHHC4 enhances stemness and activates the EZH2-STAT3 pathway.
Article
Chemistry, Medicinal
Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen
Summary: Meridianin C, a natural product derived from marine organisms, and its analogues B29 and B30 showed enhanced glucose uptake and GSK-3 beta inhibitory activities, indicating therapeutic potential for diabetes.
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Medicine, General & Internal
Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wang
Summary: This study revealed a vicious cycle between tau hyperphosphorylation and GSK-3R activation through tau-mediated acetylation of GSK-3R. Inhibiting GSK-3R acetylation competitively improved cognitive impairment and AD-like pathologies.
Article
Biochemistry & Molecular Biology
Subramaniyan Dinakar, Mani Gurubarath, Karthik Dhananjayan
Summary: This study aimed to predict the molecular interaction and dynamic behavior of naturally occurring 1,2-diphenyline ketone analogues at the adenosine triphosphate binding site of glycogen synthase kinase (GSK)-3 beta. The results showed that 1,3,5,6-Tetrahydroxyxanthone and 1,3,6-Trihydroxy-2-(2,3-dihydroxy-3-methylbutyl)-7-methoxy-8-(3-methyl-2-butenyl) xanthone may act as potential ligands to inhibit GSK-3 beta and alleviate neurodegenerative diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Xiaoqian Peng, Li Chen, Zijuan Wang, Yingying He, John Bosco Ruganzu, Hongsong Guo, Xiao Zhang, Shengfeng Ji, Liming Zheng, Weina Yang
Summary: This study demonstrates that tanshinone IIA (tan IIA) can ameliorate cognitive decline and tau pathology in APP/PS1 mice by modulating the PI3K/Akt/GSK-3β signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Neurosciences
Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue Lao
Summary: The study found that Zeaxanthin (Zea) can protect against endoplasmic reticulum stress (ERS), glycogen synthase kinase 3 beta (GSK-3 beta) activity, and tau phosphorylation.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Weizhao Chen, Qiaoying Huang, Shanshan Ma, Mingtao Li
ACS CHEMICAL NEUROSCIENCE
(2019)
Article
Neurosciences
Kunhua Hu, Qiaoying Huang, Chong Liu, Yongyi Li, Yueyue Liu, Hao Wang, Mingtao Li, Shanshan Ma
Article
Neurosciences
Junyu Li, Shanshan Ma, Jingnan Chen, Kunhua Hu, Yongyi Li, Zeyu Zhang, Zixiang Su, James R. Woodgett, Mingtao Li, Qiaoying Huang
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2020)
Article
Physiology
J. Chen, L. Wang, W. H. Liu, J. Shi, Y. Zhong, S. J. Liu, S. M. Liu
PHYSIOLOGY INTERNATIONAL
(2020)
Article
Cell Biology
Wenyi Zhou, Xuefei Zheng, Chuanfang Cheng, Guixian Guo, Yun Zhong, Weihua Liu, Kefeng Liu, Yanfang Chen, Shiming Liu, Shaojun Liu
Summary: Rab27a knockout impairs the function of EPCs, leading to compromised therapeutic effects of EPC transplantation for MI mainly through suppressing the PI3K-Akt-FoxO3a/cyclin D1 signaling pathway. In addition, Rab27a ablation significantly reduces exosome release in EPCs.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Neurosciences
Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huang
Summary: Research has shown that in the mouse model of Parkinson's disease, CREB inactivation leads to the downregulation of Nurr1, while restoring CREB activity can rescue Nurr1 expression and provide neuroprotection.
NEUROSCIENCE LETTERS
(2021)
Article
Neurosciences
Yueyue Liu, Qiaoying Huang, Zijian Wei, Shanshan Ma, James R. Woodgett, Mingtao Li, Junyu Li
Summary: The study demonstrates that in a MPTP-induced mouse model of Parkinson's disease, p62 translocates from the cytoplasm to the nucleus, which is detrimental to nigral dopaminergic neurons. GSK-3 mediates the nuclear translocation of p62 and plays a crucial role in PD neurodegeneration.
NEUROSCIENCE LETTERS
(2021)
Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Weizhao Chen, Qiongping Zheng, Qiaoying Huang, Shanshan Ma, Mingtao Li, Serge Przedborski
Summary: This study confirms that repressing PTBP1 does not convert astrocytes to dopaminergic neurons (DAns), regardless of physiological or Parkinson's disease-related pathological conditions.
Article
Multidisciplinary Sciences
Feixiang Bao, Lingyan Zhou, Rui Zhou, Qiaoying Huang, Junguo Chen, Sheng Zeng, Yi Wu, Liang Yang, Shufang Qian, Mengfei Wang, Xueying He, Shan Liang, Juntao Qi, Ge Xiang, Qi Long, Jingyi Guo, Zhongfu Ying, Yanshuang Zhou, Qiuge Zhao, Jiwei Zhang, Di Zhang, Wei Sun, Mi Gao, Hao Wu, Yifan Zhao, Jinfu Nie, Min Li, Quan Chen, Jiekai Chen, Xiao Zhang, Guangjin Pan, Hong Zhang, Mingtao Li, Mei Tian, Xingguo Liu
Summary: Mitochondrial quality control is crucial for maintaining mitochondrial homeostasis and function. Disruption of this control can lead to degradation in brain function. The drug flunarizine, known to cause parkinsonism with chronic use, was found to induce parkinsonism-like motor dysfunction and decrease mitochondrial mass specifically in the brain. The study also revealed a lysosome-associated exocytosis process of mitochondria, which may participate in the drug-induced parkinsonism.
Article
Medicine, Research & Experimental
Caiqin Wang, Bo Xie, Shi Yin, Jianghua Cao, Junhao Huang, Longyang Jin, Ge Du, Xiaohui Zhai, Rongqin Zhang, Shanshan Li, Taiyuan Cao, Hongen Yu, Xinjuan Fan, Zuli Yang, Junsheng Peng, Jian Xiao, Lei Lian
Summary: Bone marrow metastasis (BMM) in gastric cancer (GC) is often overlooked but leads to critical hematological abnormalities. This study identified ACTN2 as a gene involved in GC BMM, enhancing the metastatic capability of GC cells. ACTN2 interacts with NF-kappa B subunit RelA and forms heterotrimers, establishing a feedback loop that promotes distant metastasis. This novel mechanism suggests ACTN2 as a potential therapeutic target for GC BMM.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Qiaoying Huang, Congmin Chen, Weizhao Chen, Chaoyu Cai, Hailin Xing, Junyu Li, Mingtao Li, Shanshan Ma
Summary: Parkinson's disease is a common neurodegenerative movement disorder characterized by the loss of dopaminergic neurons. In this study, specific gene expression profiles were obtained from different cell types and brain regions in a mouse model of PD, revealing the involvement of the glycosphingolipid metabolism pathway in neuroinflammation and neurodegeneration. Microglia in the substantia nigra showed the strongest immune response in interferon-related pathways.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Shaojun Liu, Jing Chen, Jian Shi, Wenyi Zhou, Li Wang, Weilun Fang, Yun Zhong, Xiaohui Chen, Yanfang Chen, Abdelkarim Sabri, Shiming Liu
BASIC RESEARCH IN CARDIOLOGY
(2020)