标题
The heat shock response and small molecule regulators
作者
关键词
HSF1, Hsp90, Heat shock response, Neurodegeneration, Cancer
出版物
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 226, Issue -, Pages 113846
出版商
Elsevier BV
发表日期
2021-09-13
DOI
10.1016/j.ejmech.2021.113846
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A phase 2 clinical trial of the heat shock protein 90 (HSP 90) inhibitor ganetespib in patients with refractory advanced esophagogastric cancer
- (2020) Lipika Goyal et al. INVESTIGATIONAL NEW DRUGS
- Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer
- (2020) Pengfei Zhang et al. CELL DEATH AND DIFFERENTIATION
- Novel Approaches Towards a Functional Cure of HIV/AIDS
- (2020) Lucia Bailon et al. DRUGS
- The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain
- (2020) Taskeen Fathima Docrat et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Synthesis of paramagnetic ligands that target the C-terminal binding site of Hsp90
- (2020) Vishal C. Birar et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Intravenous Immunoglobulin G Suppresses Heat Shock Protein (HSP)-70 Expression and Enhances the Activity of HSP90 and Proteasome Inhibitors
- (2020) Richard J. Jones et al. Frontiers in Immunology
- Fungal mycotoxin penisuloxazin A, a novel C-terminal Hsp90 inhibitor and characteristics of its analogues on Hsp90 function related to binding sites
- (2020) Jiajia Dai et al. BIOCHEMICAL PHARMACOLOGY
- SUV39H1 is a New Client Protein of Hsp90 Degradated by Chaetocin as a Novel C-Terminal Inhibitor of Hsp90
- (2020) Bin Lian et al. Biomolecules & Therapeutics
- Functional inhibition of heat shock protein 70 by VER ‐155008 suppresses pleural mesothelioma cell proliferation via an autophagy mechanism
- (2020) Kosuke Sakai et al. Thoracic Cancer
- Stimulation of heat shock protein 90 chaperone function through binding of a novobiocin analog KU-32
- (2019) Bhaskar K. Chatterjee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition
- (2019) Rashid Gabbasov et al. CANCER BIOLOGY & THERAPY
- The Major Human Stress Protein Hsp70 as a Factor of Protein Homeostasis and a Cytokine-Like Regulator
- (2019) D. G. Garbuz et al. MOLECULAR BIOLOGY
- Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure
- (2019) Feifei Fan et al. CELL DEATH AND DIFFERENTIATION
- HSP90 inhibitor PU-H71 increases radiosensitivity of breast cancer cells metastasized to visceral organs and alters the levels of inflammatory mediators
- (2019) Şule Kale et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Identification of Isoform-Selective Ligands for the Middle Domain of Heat Shock Protein 90 (Hsp90)
- (2019) Oi Wei Mak et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Neuroprotective effects of increasing levels of HSP70 against neuroinflammation in Parkinson's disease model by inhibition of NF-κB and STAT3
- (2019) Haining Li et al. LIFE SCIENCES
- The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain
- (2019) Wei Lei et al. Frontiers in Molecular Neuroscience
- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
- (2018) Len Neckers et al. CELL STRESS & CHAPERONES
- Combined BRAF and HSP90 inhibition in patients with unresectableBRAFV600E mutant melanoma
- (2018) Zeynep Eroglu et al. CLINICAL CANCER RESEARCH
- Heat shock transcriptional factor mediates mitochondrial unfolded protein response
- (2018) Naoki Koike et al. CURRENT GENETICS
- Phase 2 Study of the HSP-90 Inhibitor AUY922 in Previously Treated and Molecularly Defined Patients with Advanced Non–Small Cell Lung Cancer
- (2018) Enriqueta Felip et al. Journal of Thoracic Oncology
- Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors
- (2018) Alireza Azimi et al. Molecular Systems Biology
- Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor
- (2018) Anuj Khandelwal et al. Nature Communications
- Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations
- (2018) Julia A. Yaglom et al. Scientific Reports
- A Phase Ib/II Study of Ganetespib With Doxorubicin in Advanced Solid Tumors Including Relapsed-Refractory Small Cell Lung Cancer
- (2018) Deepa S. Subramaniam et al. Frontiers in Oncology
- Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer
- (2018) Thomas Prince et al. Oncotarget
- KU-596 decreases mitochondrial superoxide and improves bioenergetics following downregulation of manganese superoxide dismutase in diabetic sensory neurons
- (2018) Zhenyuan You et al. EXPERIMENTAL NEUROLOGY
- First-in-human study of the epichaperome inhibitor PU-H71: clinical results and metabolic profile
- (2017) Giovanna Speranza et al. INVESTIGATIONAL NEW DRUGS
- Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain
- (2017) Wei Lei et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of heat shock transcription factors and their roles in physiology and disease
- (2017) Rocio Gomez-Pastor et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The small-molecule kinase inhibitor D11 counteracts 17-AAG-mediated up-regulation of HSP70 in brain cancer cells
- (2017) Susanne Schaefer et al. PLoS One
- Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease
- (2017) Rocio Gomez-Pastor et al. Nature Communications
- HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
- (2017) Rina M. Mbofung et al. Nature Communications
- Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging
- (2017) Johnathan Labbadia et al. Cell Reports
- Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis
- (2017) Elisabetta Vulpis et al. OncoImmunology
- Alzheimer's Disease and the Amyloid-β Peptide
- (2017) M. Paul Murphy et al. JOURNAL OF ALZHEIMERS DISEASE
- MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients.
- (2017) M. K. Yu et al. JOURNAL OF CLINICAL ONCOLOGY
- Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma
- (2017) Andrew R. Stothert et al. Scientific Reports
- The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5
- (2016) Huan-Tian Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The HSP90 inhibitor, NVP-AUY922, sensitizes KRAS-mutant non-small cell lung cancer with intrinsic resistance to MEK inhibitor, trametinib
- (2016) Kang-Seo Park et al. CANCER LETTERS
- HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors
- (2016) A. Budina-Kolomets et al. CANCER RESEARCH
- Targeting the Janus-activated kinase-2-STAT3 signalling pathway in pancreatic cancer using the HSP90 inhibitor ganetespib
- (2016) Ganji Purnachandra Nagaraju et al. EUROPEAN JOURNAL OF CANCER
- Hsp90 inhibitor, BIIB021, induces apoptosis and autophagy by regulating mTOR-Ulk1 pathway in imatinib-sensitive and -resistant chronic myeloid leukemia cells
- (2016) WEI HE et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- The Role of Toll-Like Receptor 4 in Infectious and Noninfectious Inflammation
- (2016) Monica Molteni et al. MEDIATORS OF INFLAMMATION
- Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation
- (2016) Dig B. Mahat et al. MOLECULAR CELL
- Ocular toxicity of AUY922 in pigmented and albino rats
- (2016) Danielle Roman et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- HSF1: Guardian of Proteostasis in Cancer
- (2016) Chengkai Dai et al. TRENDS IN CELL BIOLOGY
- Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1
- (2016) Nikolai Hentze et al. eLife
- Heat Shock Factor 1 Mediates Latent HIV Reactivation
- (2016) Xiao-Yan Pan et al. Scientific Reports
- Inhibition of HIV-1 reactivation by a telomerase-derived peptide in a HSP90-dependent manner
- (2016) Hong Kim et al. Scientific Reports
- Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons
- (2015) Jiacheng Ma et al. ACS Chemical Neuroscience
- Diagnosis and management of acute ischemic stroke: speed is critical
- (2015) Tapuwa D. Musuka et al. CANADIAN MEDICAL ASSOCIATION JOURNAL
- HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells
- (2015) Dae-Hee Lee et al. CELLULAR SIGNALLING
- Novel Heat Shock Protein 90 Inhibitor NVP-AUY922 Synergizes With the Histone Deacetylase Inhibitor PXD101 in Induction of Death of Anaplastic Thyroid Carcinoma Cells
- (2015) Si Hyoung Kim et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib forEGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
- (2015) Melissa L. Johnson et al. JOURNAL OF CLINICAL ONCOLOGY
- Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1
- (2015) Elena Zelin et al. JOURNAL OF MOLECULAR BIOLOGY
- Validation of the Hsp70-Bag3 Protein-Protein Interaction as a Potential Therapeutic Target in Cancer
- (2015) X. Li et al. MOLECULAR CANCER THERAPEUTICS
- FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification
- (2015) Nikos Kourtis et al. NATURE CELL BIOLOGY
- Heat-shock factor 2 is a suppressor of prostate cancer invasion
- (2015) J K Björk et al. ONCOGENE
- Combined inhibition of heat shock proteins 90 and 70 leads to simultaneous degradation of the oncogenic signaling proteins involved in muscle invasive bladder cancer
- (2015) Alice Cavanaugh et al. Oncotarget
- Novologues containing a benzamide side chain manifest anti-proliferative activity against two breast cancer cell lines
- (2014) Huiping Zhao et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1
- (2014) Swasti Raychaudhuri et al. CELL
- First-in-Human Phase I Dose Escalation Study of a Second-Generation Non-Ansamycin HSP90 Inhibitor, AT13387, in Patients with Advanced Solid Tumors
- (2014) G. I. Shapiro et al. CLINICAL CANCER RESEARCH
- Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK
- (2014) S. Dai et al. EMBO JOURNAL
- SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response
- (2014) Diana J. Liu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Long-term survival after ischemic stroke in patients with atrial fibrillation
- (2014) M. C. Fang et al. NEUROLOGY
- Heat shock protein 90 controls HIV-1 reactivation from latency
- (2014) I. Anderson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Necroptosis in health and diseases
- (2014) Wen Zhou et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease
- (2014) Marc Brehme et al. Cell Reports
- Heat shock proteins in neurodegenerative disorders and aging
- (2014) Rehana K. Leak Journal of Cell Communication and Signaling
- A first in human, safety, pharmacokinetics, and clinical activity phase I study of once weekly administration of the Hsp90 inhibitor ganetespib (STA-9090) in patients with solid malignancies
- (2013) Jonathan W Goldman et al. BMC CANCER
- The HSP90 inhibitor NVP-AUY922-AG inhibits the PI3K and IKK signalling pathways and synergizes with cytarabine in acute myeloid leukaemia cells
- (2013) Elisabeth J. Walsby et al. BRITISH JOURNAL OF HAEMATOLOGY
- Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells
- (2013) Nishant Gandhi et al. CANCER BIOLOGY & THERAPY
- Open-label, dose-escalation, safety, pharmacokinetic, and pharmacodynamic study of intravenously administered CNF1010 (17-(allylamino)-17-demethoxygeldanamycin [17-AAG]) in patients with solid tumors
- (2013) M. W. Saif et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non-Small Cell Lung Cancer
- (2013) M. A. Socinski et al. CLINICAL CANCER RESEARCH
- Phase I Study of BIIB028, a Selective Heat Shock Protein 90 Inhibitor, in Patients with Refractory Metastatic or Locally Advanced Solid Tumors
- (2013) D. Hong et al. CLINICAL CANCER RESEARCH
- First-in-Human Phase I Dose-Escalation Study of the HSP90 Inhibitor AUY922 in Patients with Advanced Solid Tumors
- (2013) C. Sessa et al. CLINICAL CANCER RESEARCH
- Down-regulation of Mortalin Exacerbates Aβ-mediated Mitochondrial Fragmentation and Dysfunction
- (2013) So Jung Park et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TAT-Hsp70 Induces Neuroprotection Against Stroke Via Anti-Inflammatory Actions Providing Appropriate Cellular Microenvironment for Transplantation of Neural Precursor Cells
- (2013) Thorsten R Doeppner et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Traumatic brain injury may be an independent risk factor for stroke
- (2013) J. F. Burke et al. NEUROLOGY
- HSP-90 inhibitor ganetespib is synergistic with doxorubicin in small cell lung cancer
- (2013) C-H Lai et al. ONCOGENE
- Sirtuins in neurodegenerative diseases: an update on potential mechanisms
- (2013) Sang-Won Min et al. Frontiers in Aging Neuroscience
- Structure, Function and Regulation of the Hsp90 Machinery
- (2013) Johannes Buchner et al. Biomedical Journal
- Phase II study of the HSP90-inhibitor BIIB021 in gastrointestinal stromal tumors
- (2012) M. A. Dickson et al. ANNALS OF ONCOLOGY
- Induction of Heat Shock Protein 70 (Hsp70) prevents Neuregulin-Induced Demyelination by Enhancing the Proteasomal Clearance of c-Jun
- (2012) Chengyuan Li et al. ASN Neuro
- Cellular and molecular mechanisms of mitochondrial function
- (2012) Laura D. Osellame et al. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
- Discovery of XL888: A novel tropane-derived small molecule inhibitor of HSP90
- (2012) Joerg Bussenius et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers
- (2012) Marc L. Mendillo et al. CELL
- Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
- (2012) James D. West et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Ganetespib (STA-9090), a Nongeldanamycin HSP90 Inhibitor, Has Potent Antitumor Activity in In Vitro and In Vivo Models of Non-Small Cell Lung Cancer
- (2012) T. Shimamura et al. CLINICAL CANCER RESEARCH
- Geldanamycin and its derivatives as Hsp90 inhibitors
- (2012) Magdalena Gorska Frontiers in Bioscience-Landmark
- Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis
- (2012) Chengkai Dai et al. JOURNAL OF CLINICAL INVESTIGATION
- C-Terminal Heat Shock Protein 90 Inhibitor Decreases Hyperglycemia-induced Oxidative Stress and Improves Mitochondrial Bioenergetics in Sensory Neurons
- (2012) Liang Zhang et al. JOURNAL OF PROTEOME RESEARCH
- The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics and Open Chromatin Status
- (2012) Elena Zelin et al. MOLECULAR CELL
- Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach
- (2012) Mark N Lee et al. NATURE IMMUNOLOGY
- mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis
- (2012) Shiuh-Dih Chou et al. PLoS One
- Hyperthermia Stimulates HIV-1 Replication
- (2012) Ferdinand Roesch et al. PLoS Pathogens
- Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease
- (2011) Julius Anckar et al. Annual Review of Biochemistry
- The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones
- (2011) Jing Li et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells
- (2011) Jeffery D Eskew et al. BMC CANCER
- Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic Syndrome
- (2011) Xiongjie Jin et al. Cell Metabolism
- The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations
- (2011) G. Floris et al. CLINICAL CANCER RESEARCH
- Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy
- (2011) K. Pourhamidi et al. DIABETOLOGIA
- Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
- (2011) Toyohide Shinkawa et al. MOLECULAR BIOLOGY OF THE CELL
- Pathophysiology, treatment, and animal and cellular models of human ischemic stroke
- (2011) Trent M Woodruff et al. Molecular Neurodegeneration
- Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases
- (2011) Daniel W. Neef et al. NATURE REVIEWS DRUG DISCOVERY
- Multicenter Phase II Trial of the Heat Shock Protein 90 Inhibitor, Retaspimycin Hydrochloride (IPI-504), in Patients With Castration-resistant Prostate Cancer
- (2011) William K. Oh et al. UROLOGY
- The Role of Tau in Alzheimer's Disease and Related Disorders
- (2010) Rodrigo Medeiros et al. CNS Neuroscience & Therapeutics
- The heat shock factor family and adaptation to proteotoxic stress
- (2010) Mitsuaki Fujimoto et al. FEBS Journal
- 150 Years of Treating Severe Traumatic Brain Injury: A Systematic Review of Progress in Mortality
- (2010) Sherman C. Stein et al. JOURNAL OF NEUROTRAUMA
- Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma
- (2010) N. Gaspar et al. MOLECULAR CANCER THERAPEUTICS
- Heat shock factors: integrators of cell stress, development and lifespan
- (2010) Malin Åkerfelt et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
- (2010) K. A. Geiler-Samerotte et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NF-κB/Rel: agonist and antagonist roles in HIV-1 latency
- (2010) Jonathan KL Chan et al. Current Opinion in HIV and AIDS
- Regulation and Function of NF-κB Transcription Factors in the Immune System
- (2009) Sivakumar Vallabhapurapu et al. Annual Review of Immunology
- A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells
- (2009) Andrew J. Massey et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
- (2009) Ji Luo et al. CELL
- Heat Shock Protein 70 Inhibits Apoptosis in Cancer Cells Through Simultaneous and Independent Mechanisms
- (2009) Vikas Dudeja et al. GASTROENTEROLOGY
- TAT-Hsp70-Mediated Neuroprotection and Increased Survival of Neuronal Precursor Cells after Focal Cerebral Ischemia in Mice
- (2009) Thorsten R Doeppner et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth
- (2009) Y H Zhao et al. ONCOGENE
- Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection
- (2009) Sophie Reuse et al. PLoS One
- Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models
- (2009) E. Caldas-Lopes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Hsp90 molecular chaperone: an open and shut case for treatment
- (2008) Laurence H. Pearl et al. BIOCHEMICAL JOURNAL
- Neural differentiation and the attenuated heat shock response
- (2008) Jingxian Yang et al. BRAIN RESEARCH
- HSP70 inhibition reverses cell adhesion mediated and acquired drug resistance in multiple myeloma
- (2008) Ramadevi Nimmanapalli et al. BRITISH JOURNAL OF HAEMATOLOGY
- P-Glycoprotein-Mediated Resistance to Hsp90-Directed Therapy Is Eclipsed by the Heat Shock Response
- (2008) A. K. McCollum et al. CANCER RESEARCH
- 153 POSTER IPI-493, a potent, orally bioavailable Hsp90 inhibitor of the ansamycin class
- (2008) J. Lee et al. EJC SUPPLEMENTS
- Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
- (2008) Jing-Ji Jin et al. Journal of Neuroinflammation
- Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer
- (2008) Dongweon Song et al. MOLECULAR CANCER THERAPEUTICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started