Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation

Ablation of P2X7 receptor exacerbates gliosis and motoneuron death in the SOD1-G93A mouse model of amyotrophic lateral sclerosis

(2013) S. Apolloni et al.   HUMAN MOLECULAR GENETICS

The NADPH Oxidase Pathway Is Dysregulated by the P2X7 Receptor in the SOD1-G93A Microglia Model of Amyotrophic Lateral Sclerosis

(2013) S. Apolloni et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

(2012) Bing Liao et al.   EXPERIMENTAL NEUROLOGY

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptome-wide miR-155 Binding Map Reveals Widespread Noncanonical MicroRNA Targeting

(2012) Gabriel B. Loeb et al.   MOLECULAR CELL

Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain

(2012) Walter J. Lukiw et al.   MOLECULAR NEUROBIOLOGY

IL6 Protects MN9D Cells and Midbrain Dopaminergic Neurons from MPP+-Induced Neurodegeneration

(2012) Björn Spittau et al.   NEUROMOLECULAR MEDICINE

MicroRNAs and neurodegeneration: role and impact

(2012) Masashi Abe et al.   TRENDS IN CELL BIOLOGY

MicroRNAs in neuronal function and dysfunction

(2012) Heh-In Im et al.   TRENDS IN NEUROSCIENCES

miR-125b suppresses the proliferation and migration of osteosarcoma cells through down-regulation of STAT3

(2011) Li-hong Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways

(2011) E. Surdziel et al.   BLOOD

Alsin and SOD1G93AProteins Regulate Endosomal Reactive Oxygen Species Production by Glial Cells and Proinflammatory Pathways Responsible for Neurotoxicity

(2011) Qiang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-365, a Novel Negative Regulator of Interleukin-6 Gene Expression, Is Cooperatively Regulated by Sp1 and NF-κB

(2011) Zheng Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-125b Potentiates Macrophage Activation

(2011) Aadel A. Chaudhuri et al.   JOURNAL OF IMMUNOLOGY

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

MicroRNAs in inflammation and immune responses

(2011) J Contreras et al.   LEUKEMIA

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling: From normal behaviour to pathological brain function

(2011) Geoffrey Burnstock et al.   PROGRESS IN NEUROBIOLOGY

Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways

(2011) Sami J. Barmada et al.   REVIEWS IN THE NEUROSCIENCES

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

(2011) Rujuan Dai et al.   Translational Research

MicroRNAs in NF- B signaling

(2011) X. Ma et al.   Journal of Molecular Cell Biology

Contribution of systemic inflammation to chronic neurodegeneration

(2010) V. Hugh Perry   ACTA NEUROPATHOLOGICA

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

(2010) Keigan M. Park et al.   CELLULAR SIGNALLING

The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia

(2010) S. A. Friedle et al.   GLIA

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

The human G93A SOD1 phenotype closely resembles sporadic amyotrophic lateral sclerosis

(2010) M. Synofzik et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Export of microRNAs and microRNA-protective protein by mammalian cells

(2010) Kai Wang et al.   NUCLEIC ACIDS RESEARCH

miRNA malfunction causes spinal motor neuron disease

(2010) S. Haramati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression

(2010) A. Git et al.   RNA

Cutting Edge: TNF-Induced MicroRNAs Regulate TNF-Induced Expression of E-Selectin and Intercellular Adhesion Molecule-1 on Human Endothelial Cells: Feedback Control of Inflammation

(2009) Yajaira Suárez et al.   JOURNAL OF IMMUNOLOGY

The Proinflammatory Action of Microglial P2 Receptors Is Enhanced in SOD1 Models for Amyotrophic Lateral Sclerosis

(2009) N. D'Ambrosi et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS

(2008) Alexander H. de Haas et al.   GLIA

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA