Combined in vivo imaging and omics approaches reveal metabolism of icaritin and its glycosides in zebrafish larvae

PHASE II DRUG METABOLIZING ENZYMES

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High-throughput screening and small animal models, where are we?

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An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 α-ethinylestradiol in zebrafish (Danio rerio)

(2010) Marijke De Wit et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Modes of Developmental Outgrowth and Shaping of a Craniofacial Bone in Zebrafish

(2010) Charles B. Kimmel et al.   PLoS One

Calycosin Promotes Angiogenesis Involving Estrogen Receptor and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC

(2010) Jing Yan Tang et al.   PLoS One

Fish proteome analysis: Model organisms and non-sequenced species

(2009) Ignasi Forné et al.   PROTEOMICS

A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner

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Zebrafish: an emerging technology forin vivopharmacological assessment to identify potential safety liabilities in early drug discovery

(2008) T P Barros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dosing effects of an antiosteoporosis herbal formula – a preclinical investigation using a rat model

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