IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
出版年份 2015 全文链接
标题
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
作者
关键词
-
出版物
NATURE MEDICINE
Volume 21, Issue 7, Pages 719-729
出版商
Springer Nature
发表日期
2015-06-29
DOI
10.1038/nm.3895
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Interleukin-23 promotes the epithelial-mesenchymal transition of oesophageal carcinoma cells via the Wnt/β-catenin pathway
- (2015) Deyu Chen et al. Scientific Reports
- Ustekinumab for the treatment of patients with active ankylosing spondylitis: results of a 28-week, prospective, open-label, proof-of-concept study (TOPAS)
- (2014) Denis Poddubnyy et al. ANNALS OF THE RHEUMATIC DISEASES
- Oncogenic Kras Activates a Hematopoietic-to-Epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia
- (2014) Florencia McAllister et al. CANCER CELL
- Combined Anti-CD40 and Anti-IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
- (2014) B. von Scheidt et al. CANCER RESEARCH
- IL-23 selectively promotes the metastasis of colorectal carcinoma cells with impaired Socs3 expression via the STAT5 pathway
- (2014) Le Zhang et al. CARCINOGENESIS
- Role of IL-23 in the pathogenesis of psoriasis: a novel potential therapeutic target?
- (2014) Andrea Chiricozzi et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L
- (2014) Ilona Kryczek et al. IMMUNITY
- Protective Immunity to Systemic Infection with Attenuated Salmonella enterica serovar Enteritidis in the Absence of IL-12 Is Associated with IL-23-Dependent IL-22, but Not IL-17
- (2014) S. M. Schulz et al. JOURNAL OF IMMUNOLOGY
- Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis
- (2014) A. R. Huppler et al. JOURNAL OF IMMUNOLOGY
- Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis
- (2014) Philip J. Mease et al. NEW ENGLAND JOURNAL OF MEDICINE
- Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials
- (2014) Richard G. Langley et al. NEW ENGLAND JOURNAL OF MEDICINE
- Human genetics of tuberculosis: a long and winding road
- (2014) L. Abel et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Mendelian susceptibility to mycobacterial disease: Genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
- (2014) Jacinta Bustamante et al. SEMINARS IN IMMUNOLOGY
- Psoriasis
- (2014) P. Di Meglio et al. Cold Spring Harbor Perspectives in Medicine
- A Phase II Randomized Study of Subcutaneous Ixekizumab, an Anti-Interleukin-17 Monoclonal Antibody, in Rheumatoid Arthritis Patients Who Were Naive to Biologic Agents or Had an Inadequate Response to Tumor Necrosis Factor Inhibitors
- (2014) Mark C. Genovese et al. Arthritis & Rheumatology
- Targeting the IL-12/IL-23 axis
- (2014) Mark J Smyth et al. OncoImmunology
- Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial
- (2013) Iain B McInnes et al. ANNALS OF THE RHEUMATIC DISEASES
- Essentials of Th17 cell commitment and plasticity
- (2013) P. Muranski et al. BLOOD
- Long-term safety of ustekinumab in patients with moderate-to-severe psoriasis: final results from 5 years of follow-up
- (2013) K.A. Papp et al. BRITISH JOURNAL OF DERMATOLOGY
- The Multifaceted Role of Th17 Lymphocytes and Their Associated Cytokines in Cancer
- (2013) Darya Alizadeh et al. Clinical & Developmental Immunology
- Clinical Features of Candidiasis in Patients With Inherited Interleukin 12 Receptor β1 Deficiency
- (2013) Monia Ouederni et al. CLINICAL INFECTIOUS DISEASES
- Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
- (2013) Suk-Kyun Yang et al. GUT
- An ACT1 Mutation Selectively Abolishes Interleukin-17 Responses in Humans with Chronic Mucocutaneous Candidiasis
- (2013) Bertrand Boisson et al. IMMUNITY
- Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell–mediated glioma rejection
- (2013) Johannes vom Berg et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients
- (2013) Paola Di Meglio et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial
- (2013) Iain B McInnes et al. LANCET
- Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial
- (2013) Dominique Baeten et al. LANCET
- Inherited IL-12p40 Deficiency
- (2013) Carolina Prando et al. MEDICINE
- Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells
- (2013) I H Chan et al. Mucosal Immunology
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
- (2013) Matthew R. Hepworth et al. NATURE
- Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
- (2013) Ashley H Beecham et al. NATURE GENETICS
- Therapeutic opportunities of the IL-22–IL-22R1 system
- (2013) Robert Sabat et al. NATURE REVIEWS DRUG DISCOVERY
- Nivolumab plus Ipilimumab in Advanced Melanoma
- (2013) Jedd D. Wolchok et al. NEW ENGLAND JOURNAL OF MEDICINE
- The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
- (2013) Michelle A. Lowes et al. TRENDS IN IMMUNOLOGY
- A balance of interleukin-12 and -23 in cancer
- (2013) Shin Foong Ngiow et al. TRENDS IN IMMUNOLOGY
- A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
- (2013) David A Martin et al. ARTHRITIS RESEARCH & THERAPY
- Biomarkers of Therapeutic Response in the IL-23 Pathway in Inflammatory Bowel Disease
- (2013) Corinne Cayatte et al. Clinical and Translational Gastroenterology
- Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomised, double-blind, placebo-controlled, phase II regimen-finding study
- (2012) P. Rich et al. BRITISH JOURNAL OF DERMATOLOGY
- Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study
- (2012) K.A. Papp et al. BRITISH JOURNAL OF DERMATOLOGY
- Opposing Roles for IL-23 and IL-12 in Maintaining Occult Cancer in an Equilibrium State
- (2012) Michele W. L. Teng et al. CANCER RESEARCH
- Interleukin 23 regulates proliferation of lung cancer cells in a concentration-dependent way in association with the interleukin-23 receptor
- (2012) Jun Li et al. CARCINOGENESIS
- Inborn errors of human IL-17 immunity underlie chronic mucocutaneous candidiasis
- (2012) Anne Puel et al. Current Opinion in Allergy and Clinical Immunology
- 1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data
- (2012) Jie Huang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Mo2083 A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of AMG 827 in Subjects With Moderate to Severe Crohn's Disease
- (2012) Stephan R. Targan et al. GASTROENTEROLOGY
- A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus atRBX1-EP300
- (2012) Antonio Julià et al. GUT
- Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
- (2012) Wolfgang Hueber et al. GUT
- Association of IL23R polymorphisms with psoriasis and psoriatic arthritis: a meta-analysis
- (2012) Kun-Ju Zhu et al. INFLAMMATION RESEARCH
- Clinical significance of circulating interleukin-23 as a prognostic factor in breast cancer patients
- (2012) Sebastiano Gangemi et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Long-term efficacy of ustekinumab in patients with moderate-to-severe psoriasis treated for up to 5 years in the PHOENIX 1 study
- (2012) A.B. Kimball et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- IL-23 is pro-proliferative, epigenetically regulated and modulated by chemotherapy in non-small cell lung cancer
- (2012) Anne-Marie Baird et al. LUNG CANCER
- Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
- (2012) Luke Jostins et al. NATURE
- Interpreting noncoding genetic variation in complex traits and human disease
- (2012) Lucas D Ward et al. NATURE BIOTECHNOLOGY
- Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis
- (2012) Kim A. Papp et al. NEW ENGLAND JOURNAL OF MEDICINE
- Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis
- (2012) Craig Leonardi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease
- (2012) William J. Sandborn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Homeostatic Regulation of Salmonella-Induced Mucosal Inflammation and Injury by IL-23
- (2012) Muyiwa Awoniyi et al. PLoS One
- Interleukin 23 Promotes Hepatocellular Carcinoma Metastasis via NF-Kappa B Induced Matrix Metalloproteinase 9 Expression
- (2012) Jian Li et al. PLoS One
- The Acute Neutrophil Response Mediated by S100 Alarmins during Vaginal Candida Infections Is Independent of the Th17-Pathway
- (2012) Junko Yano et al. PLoS One
- Mycobacterial Disease and Impaired IFN- Immunity in Humans with Inherited ISG15 Deficiency
- (2012) D. Bogunovic et al. SCIENCE
- A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
- (2012) Eimear E. Kenny et al. PLoS Genetics
- Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis
- (2011) B.E. Strober et al. BRITISH JOURNAL OF DERMATOLOGY
- Efficacy and safety of briakinumab vs. etanercept and placebo in patients with moderate to severe chronic plaque psoriasis
- (2011) A.B. Gottlieb et al. BRITISH JOURNAL OF DERMATOLOGY
- Anti-IL-23 Monoclonal Antibody Synergizes in Combination with Targeted Therapies or IL-2 to Suppress Tumor Growth and Metastases
- (2011) M. W. L. Teng et al. CANCER RESEARCH
- Th17 cells in cancer: help or hindrance?
- (2011) Cailin Moira Wilke et al. CARCINOGENESIS
- Activation and effector functions of human RORC+ innate lymphoid cells
- (2011) Ferry Cornelissen et al. CURRENT OPINION IN IMMUNOLOGY
- Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients
- (2011) Songbing He et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Lethal Tuberculosis in a Previously Healthy Adult with IL-12 Receptor Deficiency
- (2011) Payam Tabarsi et al. JOURNAL OF CLINICAL IMMUNOLOGY
- Gain-of-function humanSTAT1mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis
- (2011) Luyan Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Distinct Roles of IL-23 and IL-17 in the Development of Psoriasis-Like Lesions in a Mouse Model
- (2011) Kimiko Nakajima et al. JOURNAL OF IMMUNOLOGY
- IL-23 Is Required for Long-Term Control of Mycobacterium tuberculosis and B Cell Follicle Formation in the Infected Lung
- (2011) Shabaana A. Khader et al. JOURNAL OF IMMUNOLOGY
- A Phase III, Randomized, Controlled Trial of the Fully Human IL-12/23 mAb Briakinumab in Moderate-to-Severe Psoriasis
- (2011) Kenneth B. Gordon et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
- (2011) David M Evans et al. NATURE GENETICS
- Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
- (2011) Carl A Anderson et al. NATURE GENETICS
- Fate mapping of IL-17-producing T cells in inflammatory responses
- (2011) Keiji Hirota et al. NATURE IMMUNOLOGY
- RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
- (2011) Laura Codarri et al. NATURE IMMUNOLOGY
- The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
- (2011) Mohamed El-Behi et al. NATURE IMMUNOLOGY
- A 52-Week Trial Comparing Briakinumab with Methotrexate in Patients with Psoriasis
- (2011) Kristian Reich et al. NEW ENGLAND JOURNAL OF MEDICINE
- The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans
- (2011) Paola Di Meglio et al. PLoS One
- IL-12Rβ1 Deficiency in Two of Fifty Children with Severe Tuberculosis from Iran, Morocco, and Turkey
- (2011) Stéphanie Boisson-Dupuis et al. PLoS One
- Functional Studies on the IBD Susceptibility Gene IL23R Implicate Reduced Receptor Function in the Protective Genetic Variant R381Q
- (2011) Svetlana Pidasheva et al. PLoS One
- Inflammatory disease protective R381Q IL23 receptor polymorphism results in decreased primary CD4+ and CD8+ human T-cell functional responses
- (2011) R. Sarin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion
- (2011) R. D. Schreiber et al. SCIENCE
- Deciphering the role of Th17 cells in human disease
- (2011) Cailin Moira Wilke et al. TRENDS IN IMMUNOLOGY
- A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
- (2011) Jonathan P. Bradfield et al. PLoS Genetics
- Elevated Serum Level of IL-23 Correlates with Expression of VEGF in Human Colorectal Carcinoma
- (2010) Biljana Ljujic et al. ARCHIVES OF MEDICAL RESEARCH
- Genetic Variations of Interleukin-23R (1143A>G) and BPI (A645G), but Not of NOD2, Are Associated with Acute Graft-versus-Host Disease after Allogeneic Transplantation
- (2010) Martin Wermke et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Does IL-17 suppress tumor growth?
- (2010) S. F. Ngiow et al. BLOOD
- Prognostic significance of genetic variants in the IL-23/Th17 pathway for the outcome of T cell-depleted allogeneic stem cell transplantation
- (2010) A Carvalho et al. BONE MARROW TRANSPLANTATION
- Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis
- (2010) G. Tonel et al. JOURNAL OF IMMUNOLOGY
- IL-1RL2 and Its Ligands Contribute to the Cytokine Network in Psoriasis
- (2010) H. Blumberg et al. JOURNAL OF IMMUNOLOGY
- Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung
- (2010) Y. Okamoto Yoshida et al. JOURNAL OF IMMUNOLOGY
- IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans
- (2010) S. Kagami et al. JOURNAL OF IMMUNOLOGY
- Revisiting Human IL-12Rβ1 Deficiency
- (2010) Ludovic de Beaucoudrey et al. MEDICINE
- A phase 2, 24-week, randomized, placebo-controlled, double-blind study examining the efficacy and safety of an anti-interleukin-12 and -23 monoclonal antibody in patients with relapsing–remitting or secondary progressive multiple sclerosis
- (2010) Timothy L Vollmer et al. Multiple Sclerosis Journal
- Generation of pathogenic TH17 cells in the absence of TGF-β signalling
- (2010) Kamran Ghoreschi et al. NATURE
- Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
- (2010) Andre Franke et al. NATURE GENETICS
- Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci
- (2010) John D Reveille et al. NATURE GENETICS
- Genome-wide association identifies multiple ulcerative colitis susceptibility loci
- (2010) Dermot P B McGovern et al. NATURE GENETICS
- A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
- (2010) Amy Strange et al. NATURE GENETICS
- IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46
- (2010) Maya Eisenring et al. NATURE IMMUNOLOGY
- Clinical Disease Caused by Klebsiella in 2 Unrelated Patients With Interleukin 12 Receptor 1 Deficiency
- (2010) S. Pedraza et al. PEDIATRICS
- IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis
- (2010) M. W. L. Teng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-17 and IL-22: siblings, not twins
- (2010) Stefanie Eyerich et al. TRENDS IN IMMUNOLOGY
- Polymorphism of Interleukin-23 Receptor Gene But Not of NOD2/CARD15 Is Associated with Graft-versus-Host Disease after Hematopoietic Stem Cell Transplantation in Children
- (2009) Bernd Gruhn et al. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
- Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment
- (2009) Marcin Kortylewski et al. CANCER CELL
- Late Developmental Plasticity in the T Helper 17 Lineage
- (2009) Yun Kyung Lee et al. IMMUNITY
- Regulation of interleukin-12/interleukin-23 production and the T-helper 17 response in humans
- (2009) Lyudmila Lyakh et al. IMMUNOLOGICAL REVIEWS
- Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
- (2009) David Bending et al. JOURNAL OF CLINICAL INVESTIGATION
- Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis
- (2009) Heather R. Conti et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis
- (2009) L. van der Fits et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: IL-23 Receptor GFP Reporter Mice Reveal Distinct Populations of IL-17-Producing Cells
- (2009) Amit Awasthi et al. JOURNAL OF IMMUNOLOGY
- Ulcerative colitis–risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
- (2009) Mark S Silverberg et al. NATURE GENETICS
- Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
- (2009) Shaoguang Wu et al. NATURE MEDICINE
- Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
- (2008) Charlotte Filer et al. ARTHRITIS AND RHEUMATISM
- Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation
- (2008) A H Elmaagacli et al. BONE MARROW TRANSPLANTATION
- Interleukin-23 Orchestrates Mucosal Responses to Salmonella enterica Serotype Typhimurium in the Intestine
- (2008) I. Godinez et al. INFECTION AND IMMUNITY
- The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases
- (2008) Saleh Al-Muhsen et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
- (2008) Dror Luger et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells
- (2008) Ludovic de Beaucoudrey et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Genetic Variants of the IL-23R Pathway: Association with Psoriatic Arthritis and Psoriasis Vulgaris, but No Specific Risk Factor for Arthritis
- (2008) Ulrike Hüffmeier et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
- (2008) Craig L Leonardi et al. LANCET
- Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
- (2008) Kim A Papp et al. LANCET
- Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study
- (2008) Benjamin M Segal et al. LANCET NEUROLOGY
- Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
- (2008) Joshua D. Milner et al. NATURE
- Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease
- (2008) Subra Kugathasan et al. NATURE GENETICS
- Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
- (2008) Jeffrey C Barrett et al. NATURE GENETICS
- A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci
- (2008) Ying Liu et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started