The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans

Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

(2010) Philip P. Ahern et al.   IMMUNITY

Human Th17 Cells Comprise Heterogeneous Subsets Including IFN- -Producing Cells with Distinct Properties from the Th1 Lineage

(2010) K. Boniface et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: A Critical Functional Role for IL-23 in Psoriasis

(2010) G. Tonel et al.   JOURNAL OF IMMUNOLOGY

Comparison of Ustekinumab and Etanercept for Moderate-to-Severe Psoriasis

(2010) Christopher E.M. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

The interleukin-23 axis in intestinal inflammation

(2009) Philip P. Ahern et al.   IMMUNOLOGICAL REVIEWS

Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation

(2009) Melanie A. Kleinschek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Psoriasis

(2009) Frank O. Nestle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Expression of IL-23 and IL-17 and effect of IL-23 on IL-17 production in ankylosing spondylitis

(2009) Xinwei Wang et al.   RHEUMATOLOGY INTERNATIONAL

The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis

(2008) B Rueda et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-23 and Autoimmunity: New Insights into the Pathogenesis of Inflammatory Bowel Disease

(2008) Clara Abraham et al.   Annual Review of Medicine

Mutations inSTAT3andIL12RB1impair the development of human IL-17–producing T cells

(2008) Ludovic de Beaucoudrey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Genetic Variations in Cytokines and Cytokine Receptors Associated with Psoriasis Found by Genome-Wide Association

(2008) Kristina Callis Duffin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

(2008) Craig L Leonardi et al.   LANCET

IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants

(2008) Roelof A. de Paus et al.   MOLECULAR IMMUNOLOGY

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES