Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Xiaochong Deng, Danrong Ye, Kaiyao Hua, Hongming Song, Qifeng Luo, Amik Munankarmy, Diya Liu, Baian Zhou, Wenfang Zheng, Xiqian Zhou, Changle Ji, Xuehui Wang, Yunhe Yu, Lin Fang
Summary: The long noncoding RNA MIR22 host gene (MIR22HG) was found to be lower in breast cancer tissues and mainly located in the cytoplasm. It acts as a miR-629-5p sponge, stabilizing the expression of large tumor suppressor 2 (LATS2) to inhibit the proliferation and migration of breast cancer cells through the miR-629-5p/LATS2 pathway.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Wen -Ting Peng, Xi Jin, Xiao-En Xu, Yun-Song Yang, Ding Ma, Zhi-Ming Shao, Yi-Zhou Jiang
Summary: This study identifies ACAA1 as a potential therapeutic target for TNBC, specifically in the LAR subtype. Inhibition of ACAA1 can suppress TNBC proliferation and enhance the response to abemaciclib. The combination of trimetazidine and abemaciclib shows promise in treating ACAA1-high TNBCs.
Article
Cell Biology
Ziqian Yan, Zhimei Sheng, Yuanhang Zheng, Ruijun Feng, Qinpei Xiao, Lihong Shi, Hongli Li, Chonggao Yin, Hao Luo, Chong Hao, Wenhao Wang, Baogang Zhang
Summary: Studies compared the effects of CAFs-derived exosomes and NFs-derived exosomes on breast cancer cells, finding that CAFs-derived exosomes had a stronger enhancing effect on migration and invasion.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Qian Cai, Hsin-Sheng Yang, Yi-Chen Li, Jiang Zhu
Summary: The PDCD4 gene is located on chromosome 10q24 and encodes the PDCD4 protein, which can inhibit tumor progression and proliferation in breast cancer. Multiple regulators and biological processes control the expression of PDCD4, and its downregulation is associated with shorter overall survival in patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Jianwei Feng, Xinyue Meng
Summary: Abnormal epigenetic modifications are closely related to tumor occurrence and development in breast cancer. Histone modifications play important roles and therapeutic methods targeting these modifications are under research and development. However, further studies are needed to investigate the underlying mechanisms and refine the treatment methods.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Medicine, Research & Experimental
Yiqing Tan, Ran Sun, Lei Liu, Dejuan Yang, Qin Xiang, Li Li, Jun Tang, Zhu Qiu, Weiyan Peng, Yuanyuan Wang, Lin Ye, Guosheng Ren, Tingxiu Xiang
Summary: This study identified the tumor suppression role of DRD2 in BrCa through downregulation due to promoter methylation, correlation with longer survival in HER2-positive patients, promotion of drug sensitivity, inhibition of tumorigenesis, induction of apoptosis and necroptosis, interaction with various genes to restrict signaling pathway activation, modulation of the microenvironment, and providing predictive and therapeutic targets for BrCa.
Review
Biochemistry & Molecular Biology
Ahmed Ismail, Hesham A. El-Mahdy, Ahmed I. Abulsoud, Al-Aliaa M. Sallam, Mahmoud Gomaa Eldeib, Elsayed G. E. Elsakka, Mohamed Bakr Zaki, Ahmed S. Doghish
Summary: Breast cancer is a common and serious health threat to women. miRNAs, which regulate gene expression, play a crucial role in the pathogenesis and treatment response of breast cancer. This review aims to provide a concise summary of the potential role of oncomiRs and tumor suppressor miRNAs in breast cancer pathogenesis and therapy responses by focusing on the molecular pathways that drive them.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Taylor P. Berke, Simon H. Slight, Salman M. Hyder
Summary: The tumor suppressor protein p53 plays a crucial role in preventing cancer. Mutations in the p53 gene are associated with various cancers. Reactivating mutant p53 protein and controlling the progression of triple-negative breast cancer (TNBC) through the use of non-toxic natural compounds is recommended.
ONCOTARGETS AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Meng Yuan, Megan E. E. Barefoot, Kendell Peterson, Moray J. J. Campbell, Jan K. K. Blancato, Manjing Chen, Marcel O. O. Schmidt, Amber J. J. Kiliti, Hong-Bin Fang, Anton Wellstein, Anna T. T. Riegel, Ghada M. M. Sharif
Summary: Mutations in the ANKRD11/ANCO1 gene are implicated in neurodegenerative disorders and show loss of heterozygosity and low expression in certain cancers. This study demonstrates that low ANCO1 mRNA and protein expression levels are prognostic markers for poor clinical outcomes in breast cancer, particularly in the triple-negative subtype. Knockdown of ANCO1 in early-stage triple-negative breast cancer cells promotes aneuploidy, cellular senescence, and enhanced invasion. Loss of ANCO1 expression activates breast-cancer-specific enhancers and oncogenic pathways, accelerating the early-stage progression of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Isis Salviano Soares de Amorim, Isabelle Xavier Dias, Daphne Pinheiro, Simone Nunes de Carvalho, Pedro Nicolau-Neto, Juliana Alves Rodrigues, Priscyanne Barreto Siqueira, Matheus da Silva Oliveira, Carolina Panis, Adenilson de Souza da Fonseca, Andre Luiz Mencalha
Summary: In breast cancer, hypoxia is associated with poor prognosis. The tumor suppressor SAV1 is downregulated in cancer cells, but its expression profile and importance in BC are limited. This study aimed to investigate SAV1 expression under normoxia and hypoxia, and its potential in BC prognosis. The results showed that SAV1 expression is lower in BC samples and tumor cell lines compared to normal samples. Lower levels of SAV1 were associated with worse survival curves and may be a risk factor for BC.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Seong Beom Cho
Summary: This research used multi-omics data analysis to investigate the molecular mechanisms of tumor suppressor genes in breast cancer. The results showed that tumor suppressor genes are significantly related to gene ontology terms related to cell cycle, genome stability, RNA processing, and metastasis, revealing the regulatory mechanisms of tumor suppressor genes on cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Haoyu Liu, Zhicheng Wang, Yuntao Zhou, Yanming Yang
Summary: Women have a higher likelihood of developing breast cancer compared to other types of cancer. Various treatments including surgery, radiotherapy, chemotherapy, and immunotherapy are available based on the subtype and stage of breast cancer. Myeloid-derived suppressor cells (MDSCs) play a crucial role in promoting tumor growth and metastasis by suppressing the immune system and promoting non-immune mechanisms. MDSCs are strongly associated with poor prognosis and clinical progression in breast cancer, making them a potential target for therapy.
FRONTIERS IN IMMUNOLOGY
(2023)