Natural products with therapeutic potential in melanoma metastasis

Irradiated Riboflavin Diminishes the Aggressiveness of Melanoma In Vitro and In Vivo

(2013) Daisy Machado et al.   PLoS One

Suppression of metastasis of intravenously-inoculated B16/F10 melanoma cells by the novel ginseng-derived ingredient, gintonin: Involvement of autotaxin inhibition

(2012) SUNG HEE HWANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ipobscurine, an Indole Alkaloid from Ipomoea obscura, Inhibits Tumor Cell Invasion and Experimental Metastasis by Inducing Apoptosis

(2012) T. P. Hamsa et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Studies on Anti-metastatic and Anti-invasive Effects of Harmine Using Highly Metastatic Murine B16F-10 Melanoma Cells

(2012) T. P. Hamsa et al.   JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY

Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway

(2012) Zhijian Lu et al.   TOXICOLOGY LETTERS

E-cadherin cell–cell communication in melanogenesis and during development of malignant melanoma

(2011) Silke Kuphal et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression

(2011) Hak-Su Kim et al.   BIOCHEMICAL PHARMACOLOGY

Thujone inhibits lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice

(2011) Kodappully S. Siveen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Antiangiogenic activity of berberine is mediated through the downregulation of hypoxia-inducible factor-1, VEGF, and proinflammatory mediators

(2011) T.P. Hamsa et al.   DRUG AND CHEMICAL TOXICOLOGY

Antimetastatic potential of vernolide-A, a sesquiterpenoid from Vernonia cinerea L.

(2011) P Pratheeshkumar et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The Biflavonoid Amentoflavone Inhibits Neovascularization Preventing the Activity of Proangiogenic Vascular Endothelial Growth Factors

(2011) Valeria Tarallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gallic acid inhibits the migration and invasion of A375.S2 human melanoma cells through the inhibition of matrix metalloproteinase-2 and Ras

(2011) Chyi Lo et al.   MELANOMA RESEARCH

Resveratrol modulates the malignant properties of cutaneous melanoma through changes in the activation and attenuation of the antiapoptotic protooncogenic protein Akt/PKB

(2011) Saswati Bhattacharya et al.   MELANOMA RESEARCH

Berberine Inhibits Pulmonary Metastasis through Down-regulation of MMP in Metastatic B16F-10 Melanoma Cells

(2011) T. P. Hamsa et al.   PHYTOTHERAPY RESEARCH

Grape Seed Proanthocyanidins Inhibit Melanoma Cell Invasiveness by Reduction of PGE2 Synthesis and Reversal of Epithelial-to-Mesenchymal Transition

(2011) Mudit Vaid et al.   PLoS One

Silymarin Targets β-Catenin Signaling in Blocking Migration/Invasion of Human Melanoma Cells

(2011) Mudit Vaid et al.   PLoS One

Green Tea Catechins Reduce Invasive Potential of Human Melanoma Cells by Targeting COX-2, PGE2 Receptors and Epithelial-to-Mesenchymal Transition

(2011) Tripti Singh et al.   PLoS One

Anti-metastatic activity of the recombinant disintegrin, r-mojastin 1, from the Mohave rattlesnake

(2011) Sara Lucena et al.   TOXICON

α-Solanine Inhibits Human Melanoma Cell Migration and Invasion by Reducing Matrix Metalloproteinase-2/9 Activities

(2010) Ming-Kun Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

RETRACTED: Berberine, an isoquinoline alkaloid, inhibits melanoma cancer cell migration by reducing the expressions of cyclooxygenase-2, prostaglandin E2and prostaglandin E2receptors

(2010) Tripti Singh et al.   CARCINOGENESIS

Rac and Rho GTPases in cancer cell motility control

(2010) Matteo Parri et al.   Cell Communication and Signaling

Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro

(2010) T.P. Hamsa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of Sesquiterpenes Isolated From Largehead Atractylodes Rhizome on Growth, Migration, and Differentiation of B16 Melanoma Cells

(2010) Yan Ye et al.   INTEGRATIVE CANCER THERAPIES

Antiangiogenic Activity of Ursolic Acid

(2010) Manu Kanjoormana et al.   INTEGRATIVE CANCER THERAPIES

Inhibition of invasion and up-regulation of E-cadherin expression in human malignant melanoma cell line A375 by (-)-epigallocatechin-3-gallate

(2010) Yan Wu et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Dietary Grape Seed Proanthocyanidins Inhibit UVB-Induced Cyclooxygenase-2 Expression and Other Inflammatory Mediators in UVB-Exposed Skin and Skin Tumors of SKH-1 Hairless Mice

(2010) Som D. Sharma et al.   PHARMACEUTICAL RESEARCH

Integrins: versatile receptors controlling melanocyte adhesion, migration and proliferation

(2010) Perrine Pinon et al.   Pigment Cell & Melanoma Research

Quercetin and sulforaphane in combination suppress the progression of melanoma through the down-regulation of matrix metalloproteinase-9

(2010) SAURABH J. PRADHAN et al.   Experimental and Therapeutic Medicine

Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma

(2009) Ilaria De Stefano et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory effects of epigallocatechin-3 gallate, a polyphenol in green tea, on tumor-associated endothelial cells and endothelial progenitor cells

(2009) Noritaka Ohga et al.   CANCER SCIENCE

Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway

(2009) Dong-Hoon Shin et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-κB-dependent MMP-9 expression

(2009) Jae Ho Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Antimetastatic activity of MONCPT in preclinical melanoma mice model

(2009) Xiao-Chun Yang et al.   INVESTIGATIONAL NEW DRUGS

3,3′,4,4′,5,5′-Hexahydroxystilbene Impairs Melanoma Progression in a Metastatic Mouse Model

(2009) Verena Paulitschke et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Recent progress in understanding the pathology of malignant melanoma

(2009) Silke Kuphal et al.   JOURNAL OF PATHOLOGY

An Anticancer Effect of Curcumin Mediated by Down-Regulating Phosphatase of Regenerating Liver-3 Expression on Highly Metastatic Melanoma Cells

(2009) L. Wang et al.   MOLECULAR PHARMACOLOGY

A Recombinant Peptide, Hirudin, Potentiates the Inhibitory Effects of Stealthy Liposomal Vinblastine on the Growth and Metastasis of Melanoma

(2008) Rong-Rong Guo et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Inhibition of α4 integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with Gambogic acid

(2008) Jie Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-metastatic potential of Punarnavine, an alkaloid from Boerhaavia diffusa Linn.

(2008) K.A. Manu et al.   IMMUNOBIOLOGY

Amentoflavone Inhibits Experimental Tumor Metastasis Through a Regulatory Mechanism Involving MMP-2, MMP-9, Prolyl Hydroxylase, Lysyl Oxidase, VEGF, ERK-1, ERK-2, STAT-1, nm23 and Cytokines in Lung Tissues of C57BL/6 Mice

(2008) Chandrasekaran Guruvayoorappan et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

(+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-α in LPS-stimulated macrophages

(2008) Chandrasekharan Guruvayoorappan et al.   Innate Immunity

Artemisinin reduces human melanoma cell migration by down-regulating αVβ3 integrin and reducing metalloproteinase 2 production

(2008) Elisabetta Buommino et al.   INVESTIGATIONAL NEW DRUGS

Chemoinhibitory Effect of Mulberry Anthocyanins on Melanoma Metastasis Involved in the Ras/PI3K Pathway

(2008) Hui-Pei Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY